A5059974201- Advanced Breast Cancer Therapies
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Wound Healing and Treatments
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Estrogen and related hormone effects
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Immune cells in cancer
Nanyang Technological University
2016-2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Yale University
2011-2024
Hawaii Permanente Medical Group
2024
McMaster University
2023-2024
United States Department of Veterans Affairs
2024
University College London
2024
National University of Singapore
1996-2022
National Neuroscience Institute
2015-2021
Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression rate-limiting enzymes. One factor plays an important role metabolic response to fasting peroxisome proliferator-activated receptor α (PPARα). To gain more insight into PPARα during fasting, and regulation metabolism general, a search for unknown target genes was performed. Using subtractive hybridization (SABRE) comparing liver mRNA from...
Lipophilic compounds such as retinoic acid and long-chain fatty acids regulate gene transcription by activating nuclear receptors (RARs) peroxisome proliferator-activated (PPARs). These also bind in cells to members of the family intracellular lipid binding proteins, which includes cellular acid-binding proteins (CRABPs) (FABPs). We previously reported that CRABP-II enhances transcriptional activity RAR directly targeting receptor. Here, potential functional cooperation between FABPs PPARs...
We show here that the α, β, and γ isotypes of peroxisome proliferator–activated receptor (PPAR) are expressed in mouse epidermis during fetal development they disappear progressively from interfollicular epithelium after birth. Interestingly, PPARα β expression is reactivated adult various stimuli, resulting keratinocyte proliferation differentiation such as tetradecanoylphorbol acetate topical application, hair plucking, or skin wound healing. Using PPARα, mutant mice, we demonstrate...
The immediate response to skin injury is the release of inflammatory signals. It shown here, by use cultures primary keratinocytes from wild-type and PPAR beta/delta(-/-) mice, that such signals including TNF-alpha IFN-gamma, induce keratinocyte differentiation. This cytokine-dependent cell differentiation pathway requires up-regulation beta/delta gene via stress-associated kinase cascade, which targets an AP-1 site in promoter. In addition, pro-inflammatory cytokines also initiate...
Recent evidence has emerged that peroxisome proliferator-activated receptor alpha (PPARalpha), which is largely involved in lipid metabolism, can play an important role connecting circadian biology and metabolism. In the present study, we investigated mechanisms by PPARalpha influences pacemakers acting central clock located suprachiasmatic nucleus peripheral oscillator of liver. We demonstrate plays a specific control because it required to maintain rhythm master gene brain muscle Arnt-like...
Transplantation of mesenchymal stem cells (MSCs) derived from bone marrow has been shown to improve functional outcome in spinal cord injury (SCI). We transplanted MSCs human (hMSCs) study their potential therapeutic effect SCI the rat. In addition hMSCs, we used gene-modified hMSCs secrete brain-derived neurotrophic factor (BDNF-hMSCs). After a dorsal transection lesion was induced at T9, were microinjected on each side site. Fluorogold (FG) injected into epicenter cavity identify...
Engineering multifunctional nanocarriers for targeted drug delivery shows promising potentials to revolutionize the cancer chemotherapy. Simple methods optimize physicochemical characteristics and surface composition of need be developed in order tackle major challenges smooth translation suitable clinical applications. Here, rational development utilization mesoporous silica nanoparticles (MSNPs) targeting MDA‐MB‐231 xenograft model breast vivo are reported. Uniform redispersible...
Population-wide surveillance of COVID-19 requires tests to be quick and accurate minimize community transmissions. The detection breath volatile organic compounds presents a promising option for but is currently limited by bulky instrumentation inflexible analysis protocol. Here, we design hand-held surface-enhanced Raman scattering-based breathalyzer identify infected individuals in under 5 min, achieving >95% sensitivity specificity across 501 participants regardless their displayed...
Abstract Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal irradiation or leave behind gross amounts of undesirable residues. We report a dual-functionality hydrogel dressing intrinsic antibiofilm antioxidative properties synergistic low-leaching. The is crosslinked network tethered antibacterial cationic polyimidazolium N...
Chronic diabetic wounds are a significant global healthcare challenge. Current strategies, such as biomaterials, cell therapies, and medical devices, however, only target few pathological features have limited efficacy. A powerful platform technology combining magneto-responsive hydrogel, cells, wireless magneto-induced dynamic mechanical stimulation (MDMS) is developed to accelerate wound healing. The hydrogel encapsulates U.S. Food Drug Administration (FDA)-approved fibroblasts...
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that up-regulated by fasting, peroxisome proliferator-activated receptor agonists, and hypoxia. To further characterize FIAF, we studied regulation of FIAF mRNA protein in liver cell lines well human mouse plasma. Expression alpha (PPARalpha) PPARbeta/delta agonists rat hepatoma PPARgamma adipocytes. Transactivation, chromatin immunoprecipitation, gel shift experiments...
Glycerol, a product of adipose tissue lipolysis, is an important substrate for hepatic glucose synthesis. However, little known about the regulation glycerol metabolism. Here we show that several genes involved in metabolism glycerol, i.e., cytosolic and mitochondrial 3-phosphate dehydrogenase (GPDH), kinase, transporters aquaporin 3 9, are upregulated by fasting wild-type mice but not lacking PPARα. Furthermore, expression these was induced PPARα agonist Wy14643 PPARα−null mice. In...
PPARs (peroxisome-proliferator-activated receptors) α, β/δ and γ are a group of transcription factors that involved in numerous processes, including lipid metabolism adipogenesis. By comparing liver mRNAs wild-type PPARα-null mice using microarrays, novel putative target gene PPARα, G0S2 (G0/G1 switch 2), was identified. Hepatic expression up-regulated by fasting the PPARα agonist Wy14643 PPARα-dependent manner. Surprisingly, mRNA level highest brown white adipose tissue greatly during mouse...
Glycerol, a product of adipose tissue lipolysis, is an important substrate for hepatic glucose synthesis. However, little known about the regulation glycerol metabolism. Here we show that several genes involved in metabolism glycerol, i.e., cytosolic and mitochondrial 3-phosphate dehydrogenase (GPDH), kinase, transporters aquaporin 3 9, are upregulated by fasting wild-type mice but not lacking PPARα. Furthermore, expression these was induced PPARα agonist Wy14643 PPARα−null mice. In...