A5083817268- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Drug-Induced Hepatotoxicity and Protection
- Wound Healing and Treatments
- Pharmacogenetics and Drug Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Nail Diseases and Treatments
- Planarian Biology and Electrostimulation
- Fungal Biology and Applications
- Sulfur Compounds in Biology
- Bee Products Chemical Analysis
- Laser Applications in Dentistry and Medicine
- Redox biology and oxidative stress
- Pressure Ulcer Prevention and Management
- Neuroscience and Neuropharmacology Research
- Liver physiology and pathology
Agency for Science, Technology and Research
2020-2024
National University of Singapore
2006-2007
Abstract Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal irradiation or leave behind gross amounts of undesirable residues. We report a dual-functionality hydrogel dressing intrinsic antibiofilm antioxidative properties synergistic low-leaching. The is crosslinked network tethered antibacterial cationic polyimidazolium N...
Although the mechanisms and susceptibility factors of troglitazone-associated idiosyncratic liver injury have not been elucidated, experimental evidence has identified oxidant stress mitochondrial as a potential hazard in vitro. In search upstream mediators toxicity, we hypothesized that troglitazone-induced increased generation superoxide might activate thioredoxin-2 (Trx2)/apoptosis signal–regulating kinase 1 (Ask1) signaling pathway, leading to cell death, that, hence, mitochondrially...
Malassezia is the most abundant eukaryotic microbial genus on human skin. Similar to many human-residing fungi, has high metabolic potential and secretes a plethora of hydrolytic enzymes that can potentially modify structure external skin environment. Here we show dominant secreted protease isolated from cultured furfur an aspartyl active at all phases culture growth. We observed this protease, herein named as MfSAP1 (Malassezia 1) broader substrate cleavage profile higher catalytic...
Objective: Electrical Stimulation Therapy (EST) shows promise for the purpose of accelerating wound healing, but right electrical stimulation parameters and its mode action remain unclear. We aim to evaluate effect a new EST clinical device on epidermal repair using an in vitro human skin model.