A5081571888- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Hydrogels: synthesis, properties, applications
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Pancreatic function and diabetes
- RNA and protein synthesis mechanisms
- Protein purification and stability
- Biosensors and Analytical Detection
- Curcumin's Biomedical Applications
- Advanced Biosensing Techniques and Applications
- Biofuel production and bioconversion
- Dendrimers and Hyperbranched Polymers
- Diabetes Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Advancements in Transdermal Drug Delivery
- Advanced Fluorescence Microscopy Techniques
- S100 Proteins and Annexins
- Graphene and Nanomaterials Applications
- Bamboo properties and applications
Sun Yat-sen University
2018-2025
Chinese People's Liberation Army
2022-2024
Chinese PLA General Hospital
2015-2024
International Bamboo and Rattan Organization
2023
Fudan University
2013-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Nanjing University of Posts and Telecommunications
2019-2021
Novo Nordisk Foundation
2020-2021
Technical University of Denmark
2021
Fuzhou University
2020
Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. As key component of the innate immune system, NOD-like receptor (NLR) family, NLRP3 (pyrin domain-containing protein 3) inflammasome, when activated after ICH, promotes neuroinflammation and brain edema. MCC950 potent, selective, small-molecule inhibitor that blocks activation at nanomolar concentrations. Here, we examined effect on injury inflammation in 2 models ICH mice.In mice with induced by injection...
Chronic diabetic wounds are a significant global healthcare challenge. Current strategies, such as biomaterials, cell therapies, and medical devices, however, only target few pathological features have limited efficacy. A powerful platform technology combining magneto-responsive hydrogel, cells, wireless magneto-induced dynamic mechanical stimulation (MDMS) is developed to accelerate wound healing. The hydrogel encapsulates U.S. Food Drug Administration (FDA)-approved fibroblasts...
Oral delivery of protein drugs is an attractive route administration due to its convenience for repeated dosing and good patient compliance. However, currently oral therapeutics show very low bioavailability mainly the existence hostile gastrointestinal (GI) environments, including mucus layers intestinal epithelial barriers. Herein, using insulin as a model therapeutic, core-shell nanoparticles with thiolated hyaluronic acid (HA-SH) coating (NPHA-SH ) are produced utilizing two-step flash...
Oral chemotherapy has been emerging as a hopeful therapeutic regimen for the treatment of various cancers because its high safety and convenience, lower costs, patient compliance. Currently, nanoparticulate drug delivery systems (NDDS) exhibit many unique advantages in mediating oral delivery; however, anticancer drugs that were susceptible hostile gastrointestinal (GI) environment showed poor permeability across intestinal epithelium, most materials used carriers are nonactive excipients...
Abstract Mitochondrial fusion is linked to heart and liver ischemia‐reperfusion (IR) insult. Unfortunately, there no report elucidate the detailed influence of mitochondrial in renal IR injury. This study principally investigated mechanism by which protected kidney against Our results indicated that sirtuin 3 (Sirt3) was inhibited after injury vivo vitro. Overexpression Sirt3 improved function, modulated oxidative injury, repressed inflammatory damage, reduced tubular epithelial cell...
Near-infrared (NIR) light-responsive, injectable hydrogels are among the most promising drug delivery systems for localized anticancer therapy owing to its minimally invasive administration and remote-controlled manner. However, currently reported NIR-responsive were usually generated through physical mixing of thermosensitive polymers photothermal conversion agents. In this study, a novel type dynamic-covalent hydrogel (GelPV-DOX-DBNP) with NIR light-triggered release behavior was...
Abstract The development of lipid nanoparticles (LNPs) has enabled a successful clinical application mRNA vaccines. However, disclosure design principles for the core component‐ionizable lipids (ILs), improving delivery efficacy and organ targeting LNPs, remains formidable challenge. Herein, we report powerful strategy to modulate ILs in one‐step chemistry using Ugi four‐component reaction (Ugi‐4CR) under mild conditions. A large IL library new structures was established simply efficiently...
The shape transformation of polymer vesicles is great importance for biorelevant applications as well understanding cellular adaptation. However, realizing in a controlled manner by rationally manipulating the molecular geometry building block still challenging. Herein, we reported contraction process individual via realignment bottlebrush segments using linear-alt-bottlebrush alternating multiblock copolymer (LBAMBCP) block. well-defined LBAMBCPs, A50[(xbB)mA50]n (x = 1 and 3 refer to...
Flash Nanocomplexation (FNC) as a scalable manufacturing method to facilitate successful clinical translation of protein therapeutics.
The combination of ring-opening metathesis polymerization (ROMP) and the arm-first strategy is a widely employed "one-pot two-batch" approach for synthesizing star polymers. However, intramolecular cross-linking during core formation in homogeneous system significantly restricts production high-molar-mass polymers with complete conversion arms. In this study, we present successful synthesis diverse chemical compositions high molar mass using monomer emulsified ROMP (ME-ROMP) based on...
Much of current clinical interest has focused on mRNA therapeutics for the treatment lung-associated diseases, such as infections, genetic disorders, and cancers. However, safe efficient delivery to lungs, especially different pulmonary cell types, is still a formidable challenge. In this paper, we proposed cationic lipid pair (CLP) strategy, which utilized liver-targeted ionizable its derived quaternary ammonium CLP improve liver-to-lung tropism four-component nanoparticles (LNPs) in vivo...
Anisotropic nanoparticles such as worm-like micelles have aroused much attention due to their promising applications from templates drug delivery. The fabrication of with tunable structural stability and control over diameter length is great importance but still challenging. Herein, we report a kinetically controlled ring-opening metathesis polymerization-induced self-assembly (ROMPISA) for the robust preparation trapped diameter/length at enlarged experimental windows by rational...
Liver is responsible for the balance of blood glucose level. In this study, cholic acid and N-(2-hydroxy)-propyl-3-trimethylammonium chloride modified chitosan (HTCC-CA) was used as a liver-targeted vehicle insulin delivery. A novel approach developed to effectively load by mixing HTCC-CA in 50% ethanol water mixed solvent at pH 2 then dialysis against 7.4 phosphate buffer subsequently water. The insulin-loaded nanoparticles have an average diameter 86 nm loading efficiency 98.7%. Due random...
This study aimed to select fermentation conditions able simultaneously maximize the production of lipids and carotenoids by oleaginous yeast cultivated in wheat straw hydrolysate. An evolved strain Rhodosporidium toruloides with improved tolerance toxic compounds present hydrolysate medium was used. Experiments were performed order investigate effect temperature inoculum load on R. toruloides. Results revealed that accumulation both products can be maximized when performing at 17 °C using...
The local treatment of inflammatory bowel disease (IBD) by enzyme therapeutics is challenging owing to hostile environments in the gastrointestinal tract, leading hydrolysis and enzymatic degradation labile proteins. In this study, safe efficient drug delivery systems were developed antioxidant superoxide dismutase (SOD) sequestered within lipid-polymer hybrid nanoparticles through sequential self-assembly processes. Interestingly, we found that SOD exhibited long-term stability comparable...
Intracellular delivery of therapeutic biomacromolecules is often challenged by the poor transmembrane and limited endosomal escape. Here, we establish a combinatorial library composed 150 molecular weight-defined gemini amphiphiles (GAs) to identify vehicles that facilitate robust cytosolic proteins in vitro vivo. These GAs display similar skeletal structures but differential amphiphilicity adjusting length alkyl tails, type ionizable cationic heads, hydrophobicity or hydrophilicity spacer....
In this study, a novel glycol chitosan-Pluronic F127 conjugate (GC-PF127) was produced by adding carboxyl group to the end of Pluronic followed an amidation reaction between carboxylated and chitosan. Because hydrophobic aggregation PPO segments in F127, GC-PF127 self-assembles into micelles aqueous solution at room temperature. The can effectively load amphiphilic doxorubicin (DOX) partly negatively charged protein superoxide dismutase (SOD) neutral pH with different mechanisms, but cannot...