A5074810104- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Porphyrin and Phthalocyanine Chemistry
- Surgical Sutures and Adhesives
- Photochromic and Fluorescence Chemistry
- Supramolecular Chemistry and Complexes
- Nanoplatforms for cancer theranostics
- Intestinal and Peritoneal Adhesions
- Hernia repair and management
- Nanocluster Synthesis and Applications
- Chemical Synthesis and Analysis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adenosine and Purinergic Signaling
- Corrosion Behavior and Inhibition
- Advancements in Transdermal Drug Delivery
- Inhalation and Respiratory Drug Delivery
- 2D Materials and Applications
- Diabetes Treatment and Management
- Macrophage Migration Inhibitory Factor
- Metal and Thin Film Mechanics
Nankai University
2012-2023
Wayne State University
2020-2023
Sun Yat-sen University
2018-2021
Jiangsu University
2021
State Key Laboratory of Medicinal Chemical Biology
2014-2018
Hangzhou Dianzi University
2018
Hangzhou Academy of Agricultural Sciences
2018
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2014-2017
A novel vaccine adjuvant based on a supramolecular hydrogel of D-tetra-peptide is reported. Antigens can be easily incorporated into the by vortex or gently shaking before injection. The vaccines stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This expected to enable wide range sub-unit and help production antibodies.
Promising vaccine adjuvants of self‐assembling peptide hydrogels for protein ovalbumin (OVA) are introduced in this study. The formed by the enzyme phosphatase, and adjuvant potency both l ‐ d ‐peptide is evaluated. results indicate that, compared with clinically used alum adjuvant, can increase IgG production OVA about 1.3 3.8 times, respectively. Both gels enhance antigen uptake induce dendritic cell maturation, promote prolong accumulation lymph node, as well evoke germinal center...
Mimicking nature: The reversible formation of self-assembled nanostructures selenium-containing peptides can be controlled by redox triggers (see scheme, VC=vitamin C). As a consequence, the catalytic activity these is switchable. These results should lead to development nature-mimicking smart materials with promising properties. Self-assembly abundant in nature, ranging from relatively simple systems, such as lipid bilayers cell membranes and double-helical DNA structure, complex structures...
Oral delivery of protein drugs is an attractive route administration due to its convenience for repeated dosing and good patient compliance. However, currently oral therapeutics show very low bioavailability mainly the existence hostile gastrointestinal (GI) environments, including mucus layers intestinal epithelial barriers. Herein, using insulin as a model therapeutic, core-shell nanoparticles with thiolated hyaluronic acid (HA-SH) coating (NPHA-SH ) are produced utilizing two-step flash...
Oral chemotherapy has been emerging as a hopeful therapeutic regimen for the treatment of various cancers because its high safety and convenience, lower costs, patient compliance. Currently, nanoparticulate drug delivery systems (NDDS) exhibit many unique advantages in mediating oral delivery; however, anticancer drugs that were susceptible hostile gastrointestinal (GI) environment showed poor permeability across intestinal epithelium, most materials used carriers are nonactive excipients...
Abstract Development of highly efficient radiosensitizers is urgently desirable for addressing the resistance cancer cells to ionizing radiation, which main reason failure radiotherapy. Here, it reported first time that supramolecular nanomaterials can serve as an excellent nanoplatform developing superior radiosensitizers. A new curcumin‐based nanofiber (Cur‐SNF) by virtue a self‐assembling short peptide developed, greatly boosts radiosensitivity colorectal cancers radiation. The...
Significance Postoperative peritoneal adhesions are frequent complications for almost any types of abdominal and pelvic surgery lead to numerous medical problems. Current antiadhesion solutions include pharmacological treatment physical barriers but underperformed can only alleviate or reduce some extent. Here we show that a zwitterionic polymer solution after convenient topical application onto the traumatized surface reliably completely prevent postoperative adhesions, as demonstrated in...
Postoperative peritoneal adhesions were frequent complications for almost any types of abdominal and pelvic surgery. This led to numerous medical problems huge financial burden the patients. Current anti-adhesion strategies focused mostly on physical barriers including films hydrogels. However, they can only alleviate or reduce certain level their applying processes far from ideal. work reported development a biodegradable zwitterionic cream gel presenting series characters an idea material,...
The first supramolecular hydrogelator of curcumin is reported in this study.
Molecular hydrogels of therapeutic agents are a novel kind self-delivery system that can sustain release drugs or pro-drugs. We have previously developed molecular hydrogelator folic acid (FA)–Taxol conjugate triggered by phosphatase. In this paper, we report FA–Taxol conjugates with improved synthetic strategy. The formed the reduction disulfide bond glutathione (GSH). These could Taxol through ester hydrolysis. Compared intravenous (i.v.) injection clinically used Taxol® four times dosage,...
Although various nanomaterials have been developed for cancer theranostics, there remains a key challenge effective integration of therapeutic drugs and diagnostic agents into single multicomponent nanoparticle via simple scalable approach. Moreover, the bottlenecks nanoformulation in composition controllability, colloidal stability, drug loading capability batch-to-batch repeatability currently still hinder clinical translation nanomedicine. Herein, we report coordination-driven flash...
Although powerful adjuvants hold promise of vaccines for cancer immunotherapy, cumbersome preparation processes, elusive mechanisms and failure to induce T cell responses have largely limited their clinical translation. Due ease synthesis, good biocompatibility designable bioactivity, peptide derivatives-based supramolecular nanomaterials attracted increasing interest in improving the immunogenicity vaccines. Methods: Herein, we synthesized an NF-κB-activating nanoadjuvant (3DSNA) that is...
Background and purpose: Activation of liver X receptor (LXR) by its ligand T0901317 (T317) enhances interferon-γ (IFNγ) production to inhibit tumor growth. However, induction severe hypertriglyceridemia fatty T317 limits application. The naphthylacetic acid modified D-enantiomeric-glycine-phenylalanine-phenylalanine-tyrosine (D-Nap-GFFY) can form a nanofiber hydrogel which is selectively taken up antigen-presenting cells (APCs). In this study, we determined if D-Nap-GFFY-encapsulated...
A polymer additive of hyaluronic acid (HA) could boost the anti-cancer efficacy supramolecular nanofibers a prodrug taxol (succinated taxol).
Supramolecular nanofibers of prodrugs hold advantages for drug release due to their high payload, sustained and constant behavior, stimuli responsiveness. In this study, we report on a supramolecular hydrogel mainly formed by clinically used triamcinolone acetonide (TA). Such could only be prepared via an ester bond hydrolysis process from its prodrug succinated (STA). The resulting constantly TA in the vitro experiment. possessed excellent transscleral penetration ability, as evaluated...
Der Natur nachgeahmt: Redoxtrigger können die reversible Bildung selbstorganisierter Nanostrukturen aus Selen-haltigen Peptiden steuern (siehe Schema, VC=Vitamin C) und so ein Umschalten der katalytischen Aktivität Peptide ermöglichen. Diese Ergebnisse könnten zur Entwicklung intelligenter Materialien führen, nachgeahmt sind. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for...
Injectable molecular hydrogels hold big potential for the local delivery of anti-cancer drugs chemotherapy. We recently reported on a hydrogelator two complementary dexamethasone and Taxol. In this study, we study in detail structure–gelation property Taxol derivatives. found that even conjugates an amino acid such as glutamic acid, serine, arginine with hydrophilic side chains were efficient hydrogelators. The six gels paper characterized by rheology TEM release profile from also studied....
Self-assembling materials based on peptides have shown great potential as vaccine adjuvants. In our previous work, we demonstrated that nanofibers D-peptide Nap-GDFDFDY are good candidates for Here further found supramolecular hydrogels positively charged Nap-GDFDFDYDK adjuvants could induce stronger immune response. We designed and synthesized two derivatives, one with a positive charge (Nap-GDFDFDYDK) the other negative (Nap-GDFDFDYDE). Both of them form constructed by nanofibers. The...
We demonstrate that folic acid (FA) is a versatile molecule to construct molecular hydrogelators through conjugation with hydrophobic therapeutic agents.
We showed in this study that enzymatic triggering is a totally different pathway for the preparation of self-assembling nanomaterials to heating–cooling process. Because molecules were under lower energy levels and molecular conformation was more ordered during triggeration mild conditions, with higher supramolecular order could be obtained through biocatalytic control. In study, nanoparticles by an reaction nanofibers observed distinct trough at 318 nm from CD spectrum particle sample but...
High-capacity or high-power-density capacitors are being actively investigated for portable electronics, electric vehicles, and power systems. We describe the filler system in dielectric nanocomposites with a small loading of Au nanorods [NRs] to elucidate mechanism interfacial crystallization behavior including kinetics, crystalline morphology structure, investigate intrinsic causes concurrent great improvements constant energy density nanocomposite system. Remarkly, at high temperature,...
Abstract The development of molecular hydrogels that can be applied for mimicking bioactive molecules attracts extensive interests researchers in fields self‐assembly. In this study, we reported on several based naphthylacetic acid‐peptides containing L ‐histidine formed by the heating‐cooling process. All exhibited higher activity to hydrolyze 4‐nitrophenyl acetate (4‐NPA) than free probably due high density residue at surface self‐assembled nanofibers. To calculate 4‐NPA hydrolysis rates,...