A5026970877- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Advanced Polymer Synthesis and Characterization
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Galectins and Cancer Biology
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Entrepreneurship Studies and Influences
- Cell death mechanisms and regulation
- biodegradable polymer synthesis and properties
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Xinjiang Normal University
2025
Xinjiang Technical Institute of Physics & Chemistry
2025
Indiana University Health
2025
Indiana University – Purdue University Indianapolis
2025
Affiliated Hospital of Guizhou Medical University
2021-2024
Eisai (United States)
2009-2024
Hubei University
2024
Pudong New Area People's Hospital
2024
Abstract Immune checkpoint blockade (ICB) offers a new opportunity for treatment gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve efficacy ICB therapy. Herein, using CRISPR-Cas9-based genome-wide screening, we identified TRIM28 as one most significant regulators PD-L1, protein, in G.C. cells. Mechanistically, directly binds and stabilizes PD-L1 by inhibiting ubiquitination promoting SUMOylation. Furthermore, facilitates K63...
Although immune checkpoint blockade have demonstrated promising results, their effects on gastric cancer (GC) are under investigation. Understanding the clinical significance of PD1 and its ligands' expression, together with T cell infiltration might provide clues for biomarkers screening in GC immunotherapy. Immunohistochemistry were performed a tissue microarray including 1,014 specimens using PD1, PDL1 PDL2 antibodies. markers CD3 CD8 also stained quantified by automated image analysis....
The programmed cell death-1 receptor/programmed ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1 expression and prognosis patients with advanced gastric cancer.Totally 80 cancer 40 health controls Beijing Cancer Hospital were enrolled present study. Circulating tested by enzyme-linked immunosorbent assay (ELISA). associations level of clinicopathological features analyzed...
Significance Postoperative peritoneal adhesions are frequent complications for almost any types of abdominal and pelvic surgery lead to numerous medical problems. Current antiadhesion solutions include pharmacological treatment physical barriers but underperformed can only alleviate or reduce some extent. Here we show that a zwitterionic polymer solution after convenient topical application onto the traumatized surface reliably completely prevent postoperative adhesions, as demonstrated in...
The combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation identify which immunotherapy would improve antitumor effect.
Abstract H-ferritin (HFn) nanocarrier is emerging as a promising theranostic platform for tumor diagnosis and therapy, which can specifically target cells via binding transferrin receptor 1 (TfR1). This led us to investigate the therapeutic function of TfR1 in GC. The clinical significance was assessed 178 GC tissues by using magneto-HFn nanoparticle-based immunohistochemistry method. effects doxorubicin-loaded HFn nanocarriers (HFn-Dox) were evaluated on TfR1-positive patient-derived...
Aims: Cripto‐1 may be capable of up‐regulating signalling molecules associated with epithelial‐to‐mesenchymal transition (EMT), an important event characterized by loss E‐cadherin during malignant tumour progression and metastasis. The aim was to investigate the expression in relation clinicopathological features patient prognosis gastric cancer. Methods results: studied immunohistochemistry 118 cancer cases. Up‐regulated (CR+) found 54% (64/118) cases, whereas down‐regulated (E‐cad−) 70%...
Novel biodegradable antimicrobial hydrogels, which are promising for use as biomaterials, were prepared facilely <italic>via</italic> a thiol–ene “click” reaction under human physiological conditions using multifunctional poly(ethylene glycol) (PEG) derivatives precursors.
We recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data. Here we aim to elucidate role carcinogenesis. measured expression human GC cell lines and 90 paired primary samples, analyzed association its status with clinicopathological features. effect on cells evaluated by proliferation migration assay. To identify target genes miR-1, bioinformatic analysis protein array were...
We prepared injectable cationic hydrogels with strong antibacterial activity and remarkably low toxicity by<italic>in situ</italic>thiol–ene “click” reaction between dimethacrylate terminated poly(hexamethylene guanidine) (PHMGDMA) poly[oligo(ethylene) glycol mercaptosuccinate] (POEGMS) under physiological conditions.
Solamargine, a derivative from the steroidal solasodine in Solanum species, has exhibited anticancer activities numerous types of cancer; however, its role gastric cancer (GC) remains unknown. In present study, it was demonstrated that Solamargine suppressed viability five cell lines dose‑dependent manner and induced notable alterations morphology. Treatment with promoted apoptosis (P<0.01). increased expression long noncoding RNA (lnc) p53 transcript lnc nuclear paraspeckle assembly 1...
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) has been studied to be involved in the development and progression of several human malignancies.However, little is unveiled regarding complex mechanisms TNFRSF11B gastric cancer (GC).The clinical significance was assessed 70 160 GC tissues using immunohistochemistry method gene microarray analysis, respectively.The biological function vitro vivo assays.Immunofluorescence assay used evaluate expression β-catenin nucleus.The...
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by injury to steatotic hepatocytes that triggers the release of endogenous danger-associated molecular patterns. Recent work demonstrated exposed lipid droplets (LDs) serve as a pathogenic signal promotes monocyte infiltration and its maturation into triggering receptor expressed in myeloid cells 2 (TREM2+) macrophages MASH liver. Here we explore role LD exposure modulating inflammatory signaling macrophages. We found...
Four new molybdophosphates, A x B 4− Mo 5 P 2 O 22 (A = Na, K, Rb, Cs), were successfully synthesized by chemical substitution strategy. All compounds crystallize in the C 222 1 space group and contain an unusual onedimensional chain ∞ [Mo ] .
Abstract Precision treatment of gastric cancer requires specific biomarkers, and CLDN18.2 emerges as a promising target for patients’ stratification therapeutic guidance. In 563 cases, 54.4% patients are identified CLDN18.2‐positive, with expression negatively correlated immune‐related factors like PD‐L1, indicating “cold” tumor microenvironment. Here, novel monoclonal antibody 1D5 is created superior high specificity affinity, the antibody‐dependent fluorescence‐magnetic nanoparticle...
Abstract Background and Objectives Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression gastric remains unknown. This study was designed to investigate PTK7 cancer. Methods assessed by immunohistochemistry 201 patients. The relationship between clinicopathological features patients prognosis were statistically analyzed. Results detected 56.72% (114 of 201) immunostaining predominantly localized the cytoplasm. statistical analyses showed that...
Ultrathin antibacterial hydrogel films were prepared <italic>via</italic> layer-by-layer “click” chemistry.
The CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation. In this study, we showed the role played by CMTM3 in gastric cancer cells as gene, and examined correlation between expression clinicopathological parameters using immunohistochemistry patients different pathological stages (n = 350). We found that was reduced or silenced regulation cell lines, dramatically downregulated primary tissues. Restoration of...
// Shen Li 1, 2 , Ziyu Ting Guo 1 Xiao-Fang Xing Xiaojing Cheng Hong Du Xian-Zi Wen Jia-Fu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry Education), Division Gastrointestinal Cancer Laboratory, Peking University Hospital & Institute, Beijing, China Department Surgery, Correspondence to: Wen, e-mail: wenxz@bjmu.edu.cn Ji, jiafuj@hotmail.com Keywords: MELK, gastric cancer, prognosis, metastasis, PDX Received: July 02, 2015 Accepted: December 07, Published: 19,...
Abstract ISL1, a LIM-homeodomain transcription factor, serves as biomarker of metastasis in multiple tumors. However, the function and underlying mechanisms ISL1 gastric cancer (GC) have not been fully elucidated. Here we found that was frequently overexpressed GC FFPE samples (104/196, 53.06%), associated with worse clinical outcomes. Furthermore, overexpression loss-of-function influenced cell proliferation, invasion migration vitro vivo, including patient-derived xenograft models. We used...
Abstract Background Insulin gene enhancer protein 1, (ISL1), a LIM‐homeodomain transcription factor, is involved in multiple tumors and associated with insulin secretion metabolic phenotypes. However, the role of ISL1 stimulating glycolysis to promote tumorigenesis gastric cancer (GC) unclear. In this study, we aimed characterize expression pattern GC patients explore its molecular biological mechanism tumorigenesis. Methods We analyzed clinical significance using immunohistochemistry...
Xing X‐F, Li H, Zhong X‐Y, Zhang L‐H, Wang X‐H, Liu Y‐Q, Jia S‐Q, Shi T, Niu Z‐J, Peng Y, Du G‐G, Hu Lu A‐P, J‐Y, Chen S & Ji J‐F (2011) Histopathology 59 , 198–206 Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer Aims: The secreted phospholipase type (PLA2G2A) gene has been identified as a modifier of intestinal adenoma multiplicity Apc Min/+ mice. aim the present study was to analyse clinical significance PLA2G2A human cancer. Methods and...