A5100766391- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Uterine Myomas and Treatments
- Synthesis and Biological Evaluation
- Peptidase Inhibition and Analysis
- Endometriosis Research and Treatment
- Protease and Inhibitor Mechanisms
- Lymphoma Diagnosis and Treatment
Peking University
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Hainan Provincial Hospital of Traditional Chinese Medicine
2023
Xuzhou Medical College
2019-2022
Huashan Hospital
2011-2020
Fudan University
2011-2020
Xuzhou No.1 People's Hospital
2019
Ministry of Education of the People's Republic of China
2016
Nantong University
2009-2011
Shanghai First People's Hospital
2011
Closely located at the tumor suppressor locus 16q22.1, CKLF-like MARVEL transmembrane domain-containing member 3 and 4 (CMTM3 CMTM4) encode two CMTM family proteins, which link chemokines transmembrane-4 superfamily. In contrast to broad expression of both CMTM3 CMTM4 in normal human adult tissues, only is silenced or down-regulated common carcinoma (gastric, breast, nasopharyngeal, esophageal, colon) cell lines primary tumors. methylation was not detected epithelial with weak present 5 35...
Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cells and can be targeted suppress tumor growth.
The CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation. In this study, we showed the role played by CMTM3 in gastric cancer cells as gene, and examined correlation between expression clinicopathological parameters using immunohistochemistry patients different pathological stages (n = 350). We found that was reduced or silenced regulation cell lines, dramatically downregulated primary tissues. Restoration of...
Background: Cancer-derived immunoglobulin G (CIgG) has been detected in various cancers and plays important roles carcinogenesis.The present study aimed to investigate its clinical significance pancreatic ductal adenocarcinoma (PDAC).Methods: Using tissue microarrays (TMAs) immunohistochemistry, we assessed CIgG expression 326 patients who underwent surgical resection for PDAC.The associations between clinicopathological features outcomes were analyzed.Functional experiments also performed...
CMTM/CKLFSF is a novel family of proteins linking chemokines and TM4SF. In humans, these are encoded by nine genes, CKLF CMTM1-8/CKLFSF1-8. Here we report the characteristics expression profile CMTM3/CKLFSF3. Human CMTM3/CKLFSF3 has high sequence identity among various species similar as its mouse rat homologues. Established results both RT-PCR Quantitative Real-time PCR, gene highly transcribed in testis, leukocytes spleen. For further verification, generated polyclonal antibody against...
Patients with mucosa-associated lymphoid tissue (MALT) lymphoma often have multiple sites of disease at initial diagnosis or during the clinical course. The neoplasms are presumed to be identical, indicating dissemination relapse. However, evidence support this presumption is usually not available. We compared IGH VDJ sequences in 4 patients 2 sequential MALT lymphoma. specimen pairs were stomach and nasopharynx, lung, ocular adnexa parotid gland. median interval between biopsies was months...
Albumin-bound paclitaxel (abPTX) has been widely used in cancer treatment. However, dose-related side effects, such as myelosuppression, restrict its clinical application. Cell-based targeting drug delivery is a promising way to mitigate systematic side-effects and improve antitumoral efficacy. In this study, we demonstrated that reassembled abPTX could be engulfed by neutrophils vivo delivered tumor site, thus improving therapeutic efficacy mitigating myelosuppression. First, vitro analysis...
Lung adenocarcinoma (LUAD) is the dominant type of lung neoplasms, and radiotherapy its mainstay treatment, yet poor prognosis caused by radioresistance remains problematic. Cancer-derived immunoglobulin G (cancer-IgG) has been detected in multiple cancers plays important roles carcinogenesis. This study aimed to demonstrate that cancer-IgG associated with LUAD identify role radioresistance.Cancer-IgG expression was immunohistochemistry from 56 patients stage III western blot...
Lipid metabolism dysregulation is a key characteristic of hepatocellular carcinoma (HCC) onset and progression. Elevated expression immunoglobulin (Ig), especially the Igκ free light chain with unique Vκ4-1/Jκ3 rearrangement in cancer cells, linked to increased malignancy has been implicated colon tumorigenesis. However, role HCC carcinogenesis remains unclear. The aim this study was elucidate pivotal roles hepatocyte-derived development.
Background: Neoadjuvant therapy (NAT) is increasingly applied in pancreatic ductal adenocarcinoma (PDAC); however, accurate prediction of therapeutic response to NAT remains a pressing clinical challenge. Cancer-cell-derived sialylated immunoglobulin G (SIA-IgG) was previously identified as prognostic biomarker PDAC. This study aims explore whether SIA-IgG expression treatment-naïve fine needle aspirate (FNA) biopsy specimens could predict the pathological (PR) for Methods: Endoscopic...
Event Abstract Back to CMTM3 inhibits cell migration and invasion correlates with favorable prognosis in gastric cancer Yu Su1, Yi Lin2, Lianhai Zhang2, Baocai Liu1, Xiaohong Wang2, Henan Li1, Xiaofang Xing2, Xiaojing Cheng2, Bin Dong2, Ying Hu2, Hong Du2, Ying-ai Li2, Yubing Zhu2, Ning Ding2, Jiyou Weili Yongzhen Ma1, Xiaoyan Qiu1, Dalong Jiafu Ji2* Wenling Han1* 1 Peking University Health Science Center, China 2 Cancer Hospital & Institute, CKLF-like MARVEL transmembrane domain containing...
Background: Various human epithelial origin cancers produce cytoplasmic immunoglobulin (Ig) G. Recent studies have elucidated that it was related with the tumorigenesis. This study aimed to identify relationship between cancer cell-derived IgG expression level and clinical parameters in gastric (GC).Methods: Cancer assessed using immunohistochemistry analysis 231 primary GC tissues. The role of on cell proliferation, migration invasion were assessed.Results: Our results indicated...
Abstract Objective. To investigate expression of matrix metalloproteinases (MMPs) and the tissue inhibitors MMPs (TIMPs) at feto‐maternal interface non‐implantation sites in unruptured tubal pregnancies. Design. Prospective study. Setting. University teaching hospital. Population. Eighteen patients with pregnancy undergoing salpingectomy. Methods. Immunohistochemistry was used to detect MMP‐2, ‐9 ‐14, TIMP‐1, ‐2 ‐3 regions Fallopian tube. Serum levels human chorionic gonadotropin (β‐hCG)...
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