A5007931235- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Cell death mechanisms and regulation
- Chemokine receptors and signaling
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
Guangxi Medical University
2022-2025
Peking University
2015-2024
Peking University Cancer Hospital
2015-2024
Tianjin People's Hospital
2023
Xian Yang Central Hospital
2023
People’s Hospital of Rizhao
2014-2021
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2020
Cardiff University
2019
Helmholtz Zentrum München
2015
Technical University of Munich
2015
Abstract Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic cardiomyopathy (DCM) one the diabetes complications, usually accompanied by changes in myocardial structure function, together with cardiomyocyte apoptosis. Our study investigated effect curcumin on regulating oxidative stress (OS) apoptosis DCM. In vivo, was induced an experimental rat model streptozoticin (STZ) high‐glucose high‐fat (HG/HF) diet feeding. vitro, H9c2 cardiomyocytes were...
Hepatocellular carcinoma (HCC) is a global health concern, ranking as the fourth leading cause of cancer-related deaths worldwide. However, role piwi-interacting RNAs (piRNAs) in HCC processes has not been extensively explored. Through small RNA sequencing, our study identified specific piRNA, pir-hsa-216911, which highly expressed cells. This overexpression pir-hsa-216911 promotes cell invasion and inhibits death, particularly pyroptosis. Knocking out led to increased pyroptosis activity,...
Although immune checkpoint blockade have demonstrated promising results, their effects on gastric cancer (GC) are under investigation. Understanding the clinical significance of PD1 and its ligands' expression, together with T cell infiltration might provide clues for biomarkers screening in GC immunotherapy. Immunohistochemistry were performed a tissue microarray including 1,014 specimens using PD1, PDL1 PDL2 antibodies. markers CD3 CD8 also stained quantified by automated image analysis....
The programmed cell death-1 receptor/programmed ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1 expression and prognosis patients with advanced gastric cancer.Totally 80 cancer 40 health controls Beijing Cancer Hospital were enrolled present study. Circulating tested by enzyme-linked immunosorbent assay (ELISA). associations level of clinicopathological features analyzed...
The combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation identify which immunotherapy would improve antitumor effect.
Abstract H-ferritin (HFn) nanocarrier is emerging as a promising theranostic platform for tumor diagnosis and therapy, which can specifically target cells via binding transferrin receptor 1 (TfR1). This led us to investigate the therapeutic function of TfR1 in GC. The clinical significance was assessed 178 GC tissues by using magneto-HFn nanoparticle-based immunohistochemistry method. effects doxorubicin-loaded HFn nanocarriers (HFn-Dox) were evaluated on TfR1-positive patient-derived...
Abstract Background Although it is traditionally believed that ATP binding cassette subfamily C member 2 (ABCC2) a multidrug resistance‐associated protein correlated with worse prognosis, our previous and several other studies demonstrated the contrary to be true in gastric cancer (GC). We aim explore underlying mechanism of this discovery. Methods Our study utilized whole‐exome sequencing (WES), RNA sequencing, droplet digital PCR (ddPCR) analysis 80 samples, along comprehensive...
Cytokines are soluble proteins that exert their functions by binding specific receptors. Many cytokines play essential roles in carcinogenesis and have been developed for the treatment of cancer. In this study, we identified a novel potential cytokine using immunogenomics designated colon-derived SUSD2 factor (CSBF), also known as chromosome 10 open reading frame 99 (C10orf99). CSBF/C10orf99 is classical secreted protein with predicted molecular mass 6.5 kDa functional ligand Sushi Domain...
We recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data. Here we aim to elucidate role carcinogenesis. measured expression human GC cell lines and 90 paired primary samples, analyzed association its status with clinicopathological features. effect on cells evaluated by proliferation migration assay. To identify target genes miR-1, bioinformatic analysis protein array were...
Although preclinical work with rapalogs suggests potential in the treatment of gastric cancer, they have been less successful clinically. In this study, we report impact investigational drug PP242, a potent and selective small-molecule active-site TORC1/2 kinase inhibitor, on tumor growth metastasis. The antiproliferative effect PP242 was assessed using Cell Counting Kit-8 assay. migration invasion were analyzed wound-healing transwell assays, respectively. Matrigel capillary tube formation...
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) has been studied to be involved in the development and progression of several human malignancies.However, little is unveiled regarding complex mechanisms TNFRSF11B gastric cancer (GC).The clinical significance was assessed 70 160 GC tissues using immunohistochemistry method gene microarray analysis, respectively.The biological function vitro vivo assays.Immunofluorescence assay used evaluate expression β-catenin nucleus.The...
Abstract ISL1, a LIM-homeodomain transcription factor, serves as biomarker of metastasis in multiple tumors. However, the function and underlying mechanisms ISL1 gastric cancer (GC) have not been fully elucidated. Here we found that was frequently overexpressed GC FFPE samples (104/196, 53.06%), associated with worse clinical outcomes. Furthermore, overexpression loss-of-function influenced cell proliferation, invasion migration vitro vivo, including patient-derived xenograft models. We used...
Background: Colorectal cancer (CRC) is one of the most prevalent gastrointestinal malignancies. The incidence CRC has been rapidly increasing in China. Transferrin receptor 1 (TfR1) a key regulator cellular iron homeostasis. Several studies have demonstrated TfR1 overexpression variety human tumors, but association between and remains unclear. Methods: expression was evaluated six cell lines tumor tissues. A total 201 patients were included for immunohistochemistry 19 pairs frozen tissues...
Abstract Background and Objectives Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression gastric remains unknown. This study was designed to investigate PTK7 cancer. Methods assessed by immunohistochemistry 201 patients. The relationship between clinicopathological features patients prognosis were statistically analyzed. Results detected 56.72% (114 of 201) immunostaining predominantly localized the cytoplasm. statistical analyses showed that...
The CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation. In this study, we showed the role played by CMTM3 in gastric cancer cells as gene, and examined correlation between expression clinicopathological parameters using immunohistochemistry patients different pathological stages (n = 350). We found that was reduced or silenced regulation cell lines, dramatically downregulated primary tissues. Restoration of...
// Shen Li 1, 2 , Ziyu Ting Guo 1 Xiao-Fang Xing Xiaojing Cheng Hong Du Xian-Zi Wen Jia-Fu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry Education), Division Gastrointestinal Cancer Laboratory, Peking University Hospital & Institute, Beijing, China Department Surgery, Correspondence to: Wen, e-mail: wenxz@bjmu.edu.cn Ji, jiafuj@hotmail.com Keywords: MELK, gastric cancer, prognosis, metastasis, PDX Received: July 02, 2015 Accepted: December 07, Published: 19,...
Abstract Background Insulin gene enhancer protein 1, (ISL1), a LIM‐homeodomain transcription factor, is involved in multiple tumors and associated with insulin secretion metabolic phenotypes. However, the role of ISL1 stimulating glycolysis to promote tumorigenesis gastric cancer (GC) unclear. In this study, we aimed characterize expression pattern GC patients explore its molecular biological mechanism tumorigenesis. Methods We analyzed clinical significance using immunohistochemistry...
Abstract Background S100A9 was originally discovered as a factor secreted by inflammatory cells. Recently, found to be associated with several human malignancies. The purpose of this study is investigate expression in gastric cancer and explore its role progression. Methods tissue samples from 177 patients assessed immunohistochemistry. dimerization partner S100A8 the S100A8/A9 heterodimer were also same method. effect exogenous on motility cells AGS BGC-823 then investigated. Results...
S100A6 is involved in regulating the progression of cancer. can regulate dynamics cytoskeletal constituents, cell growth and differentiation by interacting with binding or target proteins. The present study investigated whether affects proliferation gastric cancer cells stimulating several downstream factors. Firstly, expression localization were using immunohistochemical staining, an immunoelectron microscopy laser confocal scanning. A ChIP-Chip assay was performed to determine factors...
Recent evidence demonstrates that the reprogramming of energy metabolism can interact with tumor immune microenvironment, thereby participating in progression cancer. In this study, multi-omics data 2471 gastric cancer samples were used to identify glycometabolism and its correlation microenvironment. A series bioinformatic approaches performed establish a scoring system predict survival response chemotherapy immunotherapy. Three glycometabolic subtypes two clustering subgroups determined....
Glucose-6-phosphate isomerase (GPI) is a glycolytic-related enzyme that inter-converts glucose-6-phosphate and fructose-6-phosphate in the cytoplasm. This protein also secreted into extracellular matrix by cancer cells is, therefore, called autocrine motility factor (AMF).To clarify roles of AMF/GPI gastric (GC), we collected 335 GC tissues corresponding adjacent noncancerous tissues, performed immunohistochemical studies, analyzed relationship between expression patients' clinicopathologic...
There is a continued need for investigating the roles of microRNAs (miRNAs) and their targets on progression gastric cancer (GC), especially metastasis.Here, we performed an integrated study to identify dysregulated miRNAs critical GC development progression.miR-135b was determined as promising biomarker GC.The expression level miR-135b increased among cell lines, patient tumor tissues, serum samples, correlation with aggravation patients.The in vitro functional assays demonstrated...
Neoadjuvant chemotherapy (NACT) has been established as being an effective treatment for advanced gastric cancer (GC), while the predictive biomarker of NACT efficacy remains under investigation. Aspartate β-hydroxylase (ASPH) represents attractive target which is a highly conserved transmembrane enzyme overexpressed in human GC, and participates malignant transformation by promoting tumor cell motility. Here, we evaluated expression ASPH immunohistochemistry 350 GC tissues (including...