A5100523587- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Optimism, Hope, and Well-being
- MicroRNA in disease regulation
- Medical Imaging and Pathology Studies
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- Healthcare and Venom Research
- COVID-19 Clinical Research Studies
- Acupuncture Treatment Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Cardiac Health and Mental Health
- Sepsis Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Microbial Community Ecology and Physiology
- Advanced biosensing and bioanalysis techniques
Xi'an Medical University
2020-2025
Air Force Medical University
2014-2025
Gansu Agricultural University
2023-2025
Tang Du Hospital
2018-2025
Zhejiang Medicine (China)
2024
Wuyi University
2024
Hangzhou Academy of Agricultural Sciences
2024
Zhejiang A & F University
2024
Suzhou Research Institute
2023-2024
Jiangxi University of Traditional Chinese Medicine
2024
Summary Background SARS-CoV-2 is a novel human coronavirus, there no specific antiviral drugs. It has been proved that host-cell-expressed CD147 could bind spike protein of and involve in host cell invasion. Antibody against block the infection SARS-CoV-2. We aimed to assess efficacy safety meplazumab, humanized anti-CD147 antibody, as add-on therapy patients with COVID-19 pneumonia. Methods All received recommended strategy from Chinese Clinical Guidance for Pneumonia Diagnosis Treatments...
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is humanized IgG
Early prediction and identification for severe patients during the pandemic of COVID-19: A COVID-19 risk model constructed by
Abstract Background Hantaan virus (HTNV), Seoul (SEOV) and Puumala (PUUV) are major serotypes of the Hantavirus, which can cause hemorrhagic fever with renal syndrome (HFRS). The pathophysiology HFRS in humans is complex determinants associated mortality, especially coagulation fibrinolysis disorders, still not been fully elucidated. Severe patients usually manifest multiple complications except for acute kidney injury (AKI). aim this study was to observe levels peripheral blood routine,...
Abstract Background Although it is traditionally believed that ATP binding cassette subfamily C member 2 (ABCC2) a multidrug resistance‐associated protein correlated with worse prognosis, our previous and several other studies demonstrated the contrary to be true in gastric cancer (GC). We aim explore underlying mechanism of this discovery. Methods Our study utilized whole‐exome sequencing (WES), RNA sequencing, droplet digital PCR (ddPCR) analysis 80 samples, along comprehensive...
In mammals, exposure to low temperatures induces white adipose tissue (WAT) browning and alters lipid metabolism promote thermogenesis, thereby maintaining body temperature. However, this response varies across different depots. study, Hezuo pigs were exposed either room temperature (23 ± 2 °C) or (−15 for periods of 12 h, 24 48 5 d, 10 15 d. Inguinal fat (IF) perirenal (PF) collected analyzed using hematoxylin eosin (HE) staining, transmission electron microscopy, RT-qPCR, RNA-seq....
Hemorrhagic fever with renal syndrome (HFRS) has become an important public health concern because of the high incidence and mortality rates, limited treatment vaccination. Until now, clinical studies on characteristics outcomes in critical patients HFRS have been limited. The aim this study was to observe cumulative proportions surviving explore predictive effects risk factors for prognosis. A detailed retrospective analysis records conducted. enrolled were treated centre infectious...
Background Hantaan virus (HTNV) infection causes a severe form of HFRS(hemorrhagic fever with renal syndrome)in Asia. Although HTNV has been isolated for nearly forty years, the pathogenesis HFRS is still unknown, and little known regarding signaling pathway that activated by virus. Methodology/Principal Findings Cardamonin was selected as NF-κB inhibitor, indirect immunofluorescence assays were used to detect effect cardamonin on HTNV-infected HUVECs. The HTNV-induced phosphorylation Akt...
Objectives The aim of this study was to investigate the clinical characteristics and outcomes critical patients with hemorrhagic fever renal syndrome (HFRS) complicated by acute respiratory distress (ARDS). Materials Methods To observe demographic, epidemiological characteristics, explore predictive effects for prognosis in laboratory findings, we conducted a detailed retrospective analysis records HFRS ARDS, treated at center infectious diseases, Tangdu Hospital, between January 2008...
Abstract Acquired platinum resistance poses a significant therapeutic impediment to ovarian cancer patient care, accounting for more than 200,000 deaths annually worldwide. We previously identified that overexpression of the antioxidant superoxide dismutase 1 ( SOD1 ) in is associated with platinum-resistant phenotype via conferring oxidative stress against compounds. further demonstrated enzymatic inhibition using small-molecule inhibitors or silencing RNA interference (RNAi) increased...
Background Hantaan virus is a major zoonotic pathogen that causesing hemorrhagic fever with renal syndrome (HFRS). Although HFRS pathogenesis has not been entirely elucidated, the importance of host-related immune responses in widely recognized. CD163, monocyte and macrophage-specific scavenger receptor plays vital function hosts can reduce inflammation, shed during activation as soluble CD163 (sCD163). The aim this study was to investigate pathological significance sCD163 patients HFRS....
Cadmium (Cd) is known as a highly toxic heavy metal and has been reported to induce hepatotoxicity in animals. Nano-selenium (NSe) an antioxidant that plays many biological roles such oxidative stress alleviation. The purpose of this study explore the mechanism action by which NSe inhibits Cd-induced hepatic toxicity stress. Sixty eight-week-old male Kunming mice were randomly divided into four groups (15 per group). control group cadmium received distilled water, whereas sodium-selenite 0.2...
Abstract The objective of this study was to explore the role laboratory parameters as early indicators severity and effective predictors prognosis in patients with hemorrhagic fever renal syndrome (HFRS). A total 356 were enrolled divided into mild, moderate, severe critical types according clinical classification HFRS. levels 12 routinely tested during acute stage among four compared. predictive values for analyzed, a risk model based upon constructed. white blood counts (WBC), platelets...