A5100345949- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Biochemical and Molecular Research
- Fungal Infections and Studies
- Fungal and yeast genetics research
- Viral Infections and Vectors
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- COVID-19 Impact on Reproduction
- Adolescent Sexual and Reproductive Health
- Clostridium difficile and Clostridium perfringens research
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Fungal Biology and Applications
- COVID-19 and healthcare impacts
- Peripheral Neuropathies and Disorders
- Cancer-related molecular mechanisms research
- Infection Control in Healthcare
- Dermatological and COVID-19 studies
Huzhou University
2025
Peking University Shenzhen Hospital
2024
Qiqihar Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Harbin Institute of Technology
2023
The First Affiliated Hospital, Sun Yat-sen University
2021-2022
Sun Yat-sen University
2021-2022
Brown University
2021-2022
Southwest Minzu University
2022
First Affiliated Hospital of Henan University
2022
To evaluate the relation between penicillin allergy and development of meticillin resistant Staphylococcus aureus (MRSA) C difficile.Population based matched cohort study.United Kingdom general practice (1995-2015).301 399 adults without previous MRSA or difficile enrolled in Health Improvement Network database: 64 141 had a 237 258 comparators on age, sex, study entry time.The primary outcome was risk incident difficile. Secondary outcomes were use β lactam antibiotics alternative...
Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently unavailable. Since niacin is a vitamin cytoprotective and anti-inflammatory functions, this study aimed evaluate possible functional roles underlying mechanisms of action as an anti-COVID-19 -CRC therapy.We used series network pharmacology-based computational analyses understand characterize binding capacity, biological...
Objectives: To find and compare the levels of acceptance barriers to voluntary counselling testing (VCT) among adults in two different counties Guizhou province, China, one which China CARES project was operating other it not. Design: A longitudinal design with two-stage cluster sampling employed. Methods: total 1012 participants were recruited counties. All interviewed, then given a coupon for free VCT after interview. Participants paid returning within 2 months, whether tested or The...
Abstract Background We evaluated an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine for immunogenicity and safety in adults aged 18–59 years. Methods In this randomized, double-blinded, controlled trial, healthy received a medium dose (MD) or high (HD) of the at interval either 14 days 28 days. Neutralizing antibody (NAb) anti-S anti-N antibodies were detected different times, adverse reactions monitored after full immunization. Results A total 742 enrolled...
China implemented containment measures to stop SARS-CoV-2 transmission in response the COVID-19 epidemic. After first epidemic wave, we conducted population-based serological surveys determine extent of infection, risk factors for and neutralization antibody levels assess real infections random sampled population.We used a multistage, stratified cluster sampling strategy conduct three areas - Wuhan, Hubei Province outside six provinces selected on incidence strategy. Participants were...
The most commonly used antifungal drugs are the azole compounds, which interfere with biosynthesis of fungal-specific sterol: ergosterol. pathogenic yeast Candida glabrata acquires resistance to like fluconazole via mutations in a gene encoding transcription factor called PDR1. These PDR1 lead overproduction drug transporter proteins ATP-binding cassette Cdr1. In other species, mutant forms Upc2 associated resistance, owing important role this protein control expression genes enzymes...
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of preferred combination antiretroviral therapies used for the treatment HIV. These regimens extremely effective in suppressing virus replication. Structure-based optimization diaryl ether led to discovery a new series pyrazolo[3,4-c]pyridazine NNRTIs that bind enzyme human immunodeficiency virus-1 (HIV-RT) an expanded volume relative most other this class.The binding mode maintains beta13 and beta14 strands...
Non-typhoidal Salmonella (NTS) infections typically present as localized inflammation near the intestinal mucosal epithelium. However, some NTS strains can breach barrier and enter bloodstream, leading to bacteremia severe systemic infections. The mechanisms by which invades bloodstream remain unclear. In this study, we isolated 36 from patients with diarrhea at First Affiliated Hospital of Huzhou University. Strains represented two distinct clinical manifestations, were subjected...
Background Hantaan virus (HTNV) infection causes a severe form of HFRS(hemorrhagic fever with renal syndrome)in Asia. Although HTNV has been isolated for nearly forty years, the pathogenesis HFRS is still unknown, and little known regarding signaling pathway that activated by virus. Methodology/Principal Findings Cardamonin was selected as NF-κB inhibitor, indirect immunofluorescence assays were used to detect effect cardamonin on HTNV-infected HUVECs. The HTNV-induced phosphorylation Akt...
Abstract Background The management of critically ill patients with coronavirus disease 2019 (COVID‐19), caused by a new human virus severe acute respiratory syndrome 2 (SARS‐CoV‐2), is challenging. Recently, there have been several reports inconsistent results after treatment convalescent plasma (CP) on COVID‐19, which was produced neutralizing antibody titer and tested in P3 or P4 laboratory. However, due to the limitation conditions mass production plasma, most producers hardly had...
Asthma is a heterogeneous disease with variable symptoms, which presents cough either as the sole or predominant symptom without wheezing. We compared clinical and pathophysiological characteristics of asthma (CPA), variant (CVA) classic (CA) in order to determine any differential phenotypic traits.In 20 clinics across China, total 2088 patients were finally recruited, including 327 CVA, 1041 CPA 720 CA patients. recorded wheezing visual analogue scale, Leicester questionnaire (LCQ) control...
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are part of the preferred treatment regimens for individuals infected with HIV. These NNRTI-based efficacious, but most popular NNRTIs have a low genetic barrier to resistance and been associated adverse events. There is therefore still need efficacious antiviral medicines that facilitate patient adherence allow durable suppression viral replication. As an extensive program targeted toward discovery favorable pharmacokinetic...
Abstract Objectives The prevalence of antibodies to SARS-CoV-2 among blood donors in China remains unknown. To reveal the missing information, we investigated seroprevalence cities Wuhan, Shenzhen, and Shijiazhuang China. Design Cross-sectional study Setting Three centers, located central, south north China, respectively, recruiting from January April 2020. Participants 38,144 healthy donated Shenzhen were enrolled, who all met criteria for donation during COVID-19 pandemic Main outcome...
Abstract With the relatively serious global epidemic outbreak of SARS-CoV-2 infection, public concerns focus on not only clinical therapeutic measures and quarantine for this disease but also development vaccines. The technical design our inactivated vaccine provides a viral antigen that enables exposure more than one structural protein based upon antibody composition COVID-19 patients’ convalescent serum. This led to valid immunity with increasing neutralizing titers CTL response detected...
The coronavirus disease 2019 (COVID-19) pandemic continues to put strain on health systems in the United States, leading significant shifts delivery of routine clinical services, including those offering HIV pre-exposure prophylaxis (PrEP). We aimed assess whether individuals discontinued PrEP use at higher rates during COVID-19 and extent which disruptions usual care were mitigated through telehealth. Using data from an ongoing prospective cohort men who have sex with (MSM) newly initiating...
Abstract G9 group A rotaviruses (RVAs) are considered emerging pathogens in pigs and humans, a potential host reservoir for human RVAs. In this study, RVAs of two genotypes, G9P[23] G9P[13], were successfully isolated the genomic sequences obtained, genome constellation is G9‐P[23]‐I5‐R1‐C1‐M1‐A8‐N1‐T1‐E1‐H1 G9‐P[13]‐I5‐R1‐C1‐M1‐A8‐N1‐T7‐E1‐H1 respectively. One strain which amplified from clinic faecal sample had an unique G9‐P[23]‐I1‐R1‐C1‐M1‐A8‐N1‐T1‐E1‐H1. All segments three porcine...