A5100366446- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Virology and Viral Diseases
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Orthopaedic implants and arthroplasty
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Ion Transport and Channel Regulation
- COVID-19 Clinical Research Studies
- Advanced Breast Cancer Therapies
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
Third Hospital of Hebei Medical University
2020-2025
Hebei Medical University
2015-2025
Nanjing Drum Tower Hospital
2023-2024
Anhui Provincial Hospital
2024
Yanbian University Hospital
2024
University of Science and Technology of China
2024
Nankai University
2023
Xiamen University
2023
Jilin University
2016-2023
Shandong University of Traditional Chinese Medicine
2023
Depression is a debilitating mental illness and often comorbid with metabolic disorders such as type 2 diabetes. Adiponectin an adipocyte–derived hormone antidiabetic insulin-sensitizing properties. Here we show that adiponectin levels in plasma are reduced chronic social-defeat stress model of depression, which correlates decreased social interaction time. A reduction caused by haploinsufficiency results increased susceptibility to aversion, “anhedonia,” learned helplessness causes impaired...
Adiponectin is the most abundant adipokine secreted from adipocytes. Accumulating evidence suggests that physiological roles of adiponectin go beyond its metabolic effects. In present study, we demonstrate receptors 1 and 2 (AdipoR1 AdipoR2) are expressed in adult hippocampal neural stem/progenitor cells (hNSCs). treatment increases proliferation cultured hNSCs a dose- time-dependent manner, whereas apoptosis differentiation into neuronal or glial lineage were not affected. activates...
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is humanized IgG
Mitochondrial quality control plays an important role in maintaining mitochondrial homeostasis and function. Disruption of degrades brain We found that flunarizine (FNZ), a drug whose chronic use causes parkinsonism, led to parkinsonism-like motor dysfunction mice. FNZ induced decreased mass specifically the brain. content both neurons astrocytes, without affecting number nigral dopaminergic neurons. In human neural progenitor cells, also depletion. Mechanistically, independent ATG5- or...
Respiratory tract infections (RTIs) are severe acute infectious diseases, which require the timely and accurate identification of pathogens involved so that individual treatment plan can be selected, including optimized use antibiotics.However, high throughput ultrasensitive quantification multiple nucleic acids is a challenge in point care testing (POCT) device.Methods: Herein, we developed 2×3 microarray on lateral flow strip with surface enhanced Raman scattering (SERS) nanotags encoding...
The lysosomal degradation pathway, autophagy, is essential for the maintenance of cellular homeostasis. Recently, autophagy has been demonstrated to be required in process adipocyte conversion. However, its role mature adipocytes under physiological and pathological conditions remains unclear. Here, we report a major function BECN1 regulation basal adipocytes. We also show that berberine, natural plant alkaloid, inhibits adipose tissue mice fed high-fat diet via downregulation expression....
Proteins of all living cells undergo a myriad post-translational modifications (PTMs) that are critical to multifarious life processes. In this study, we describe the first comprehensive multiple PTM-omics atlas in parallel with quantitative proteome analyses two representative species African trypanosomes, Trypanosoma brucei and evansi. Ten PTM types approximately 40,000 modified sites 150 histone marks fine map on each protein trypanosomes were accomplished. The biologically different...
Video generation has achieved significant advances through rectified flow techniques, but issues like unsmooth motion and misalignment between videos prompts persist. In this work, we develop a systematic pipeline that harnesses human feedback to mitigate these problems refine the video model. Specifically, begin by constructing large-scale preference dataset focused on modern models, incorporating pairwise annotations across multi-dimensions. We then introduce VideoReward, multi-dimensional...
Sarcopenia had been identified as a factor influencing the postoperative outcomes of lumbar surgery. The effect sarcopenia on surgical in patients who underwent oblique lateral interbody fusion (OLIF) not yet examined. aim our study was to investigate association between and low back pain (LBP) following OLIF provide recommendations for strategy. 116 were retrospectively reviewed. Patients classified into group (Group SP) non-sarcopenia NSP). According whether instruments performed, Group SP...
The number of reported cases resistance to tigecycline is increasing. aim this study was evaluate the current standard dosage regimen from a pharmacokinetic/pharmacodynamic (PK/PD) perspective.Pharmacokinetic parameters and microbiological data were analyzed by Monte Carlo simulation in an evaluation effectiveness.Tigecycline exhibits excellent vitro antimicrobial activity, however dosing fails achieve best outcome vivo for common drug-resistant strains, including Acinetobacter baumannii,...
Increasing hepatic stellate cell (HSC) death is an attractive approach for limiting liver fibrosis. We investigated the molecular mechanisms underlying effects of sorafenib on HSCs. LX2 cells were incubated with and a variety inhibitors apoptosis, autophagy, necrosis. Electron microscopy was used to observe autophagosomes. Inhibitors siRNA examine role Akt/mTOR/p70S6K JNK pathways. Ultrastructural analysis revealed that rat HSCs treated 5 μmol/l accumulated residual digested material empty...
Gastric cancer is one of the most common cancers leading to tumor-related deaths worldwide. Chicoric acid (CA) exhibits a variety protective effects in different diseases. However, its role regulating tumor progression has not been reported. Autophagy, as conserved catabolic process, sustains cellular homoeostasis responding stress modulate cell fate. In study, CA on gastric were investigated. The results indicated that treatment markedly reduced viability and induced apoptosis cells,...
Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity bats, we screened identified a series bat major histocompatibility complex (MHC) I Ptal-N*01:01-binding peptides derived from four different bat-borne i.e., Hendra virus (HeV), Ebola (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), H17N10 influenza-like virus. The structures Ptal-N*01:01...
Objective Client adherence is vital for effective methadone maintenance treatment (MMT). This study explores the pattern and associated factors of client adherence, drop-out re-enrolment in Chinese MMT programme over period 2006–2013. Methods retrospective was conducted 14 clinics Guangdong Province, China. We employed Kaplan-Meier survival analysis to estimate rates clients multivariate Cox regression identify factors. Results Among 1,512 participants, 79% have experienced 'drop-out' during...
As a new member of the vasculoprotective gasotransmitter family, hydrogen sulfide (H2S) functions similar to nitric oxide (NO) and carbon monoxide (CO). Endothelial cell (EC) death autophagy enable cells cope with progression cardiovascular diseases. However, impacts underlying mechanisms H2S in autophagic process ECs are not completely understood. Here, we investigated effects on human vascular ECs.Human umbilical vein endothelial (HUVECs) were exposed different concentrations (0, 50, 100,...
Coronavirus disease 2019 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a global pandemic.Intermediate horseshoe bats (Rhinolophus affinis) are hosts of RaTG13, the second most phylogenetically related viruses to SARS-CoV-2.We report binding between intermediate bat ACE2 (bACE2-Ra) and SARS-CoV-2 receptor-binding domain (RBD), supporting pseudotyped viral infection.A 3.3 Å resolution crystal structure bACE2-Ra/SARS-CoV-2 RBD complex was determined.The...
Formononetin (FN), an isoflavone compound mainly isolated from soy and red clover, had showed its anti-inflammation, antioxidative effects in some degenerative diseases cholestasis. However, the role of FN protecting ischemia/reperfusion- (I/R-) induced liver injury possible mechanism were unclear. In this study, on investigated a rat hepatic I/R model; further, mitophagy-related proteins measured by immunoblotting or immunofluorescence. The roles PHB2 PINK1 regulating mitophagy verified...