A5052040807- Aldose Reductase and Taurine
- Toxoplasma gondii Research Studies
- Malaria Research and Control
- Biochemical effects in animals
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Alcohol Consumption and Health Effects
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasitic Infections and Diagnostics
- Research on Leishmaniasis Studies
- Prenatal Substance Exposure Effects
- Herpesvirus Infections and Treatments
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Polysaccharides and Plant Cell Walls
- T-cell and B-cell Immunology
- Venomous Animal Envenomation and Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- Cytomegalovirus and herpesvirus research
- Cardiac Ischemia and Reperfusion
- Biochemical and Molecular Research
- Gout, Hyperuricemia, Uric Acid
Shenyang Agricultural University
2015-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Central South University
2025
Tonghua Normal University
2023
Beijing Ditan Hospital
2023
Capital Medical University
2023
Guangxi Maternal and Child Health Hospital
2022
Prevention Institute
2022
Quanzhou Normal University
2014-2022
Depression, a psychiatric and dysthymic disorder, severely affects the learning, work life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on brain development can improve learning ability memory. Our study investigated antidepressant-like taurine pre-treatment by examining changes in depression-like behavior, hormones, neurotransmitters, inflammatory factors neurotrophic...
Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, in non-histone proteins, especially proteins of early branching organisms, is not well understood. Energy metabolism and the histone repertoire diverging protozoan parasite Trypanosoma brucei , causative agent African trypanosomiasis, markedly diverge from those conventional eukaryotes. Here, we present first exhaustive proteome-wide investigation lactylated sites T. . We...
It has been demonstrated that taurine is one of the most abundant free amino acids in male reproductive system, and can be biosynthesized by organs. But effect on reproduction poorly understood. Taurine β-alanine (taurine transport inhibitor) were offered water to rats different ages. The effects hormones, testis marker enzymes, antioxidative ability sperm quality investigated. levels T LH obviously increased supplementation ages, level E was also significantly elevated baby rats. SOD, ACP,...
Objective . The underlying cause for postmastectomy pain syndrome (PMPS) and its impact on quality of life remain unclear. objective this study aims to determine retrospectively the prevalence PMPS, predicting risk factors, life. Method In survey, 225 women completed a battery questionnaires. questionnaires comprised short form McGill Pain Questionnaire (SF‐MPQ) exploring characteristics description pain, Short Form‐36 (SF‐36) Health Survey evaluating Logistic regression analyses were...
Proteins of all living cells undergo a myriad post-translational modifications (PTMs) that are critical to multifarious life processes. In this study, we describe the first comprehensive multiple PTM-omics atlas in parallel with quantitative proteome analyses two representative species African trypanosomes, Trypanosoma brucei and evansi. Ten PTM types approximately 40,000 modified sites 150 histone marks fine map on each protein trypanosomes were accomplished. The biologically different...
Abstract Host immune responses are tightly controlled by various factors during infection, and protozoan parasites also manipulate the system to evade surveillance, leading an evolutionary arms race in host‒pathogen interactions; however, underlying mechanisms not fully understood. We observed that level of superoxide dismutase 3 (SOD3) was significantly elevated both Plasmodium falciparum malaria patients mice infected with four parasite species. SOD3-deficient had a substantially longer...
Toxoplasma gondii is a unicellular protozoan parasite of the phylum Apicomplexa. The repeatedly goes through cycle invasion, division and induction host cell rupture, which an obligatory process for proliferation inside warm-blooded animals. It known that biology controlled by variety mechanisms ranging from genomic to epigenetic transcriptional regulation. In this study, we investigated global protein posttranslational lysine crotonylation 2-hydroxyisobutyrylation two T. strains, RH ME49,...
Abstract Artemisinin (ART) and dihydroartemisinin (DHA), apart from their profound anti-malaria effect, can also beneficially modulate the host immune system; however, underlying molecular mechanisms remain unclear. Here, we report that DHA selectively induced T-cell activation, with an increased proportion of Ki67 + CD4 T cells, CD25 interferon (IFN)-γ-producing CD8 Brdu cells neutrophils, which was found to enhance cellular immunity experimental malaria overcome immunosuppression in mice....
Abstract The biology of Toxoplasma gondii, the causative pathogen one most widespread parasitic diseases (toxoplasmosis), remains poorly understood. Lactate, which is derived from glucose metabolism, not only an energy source in a variety organisms, including T. but also regulatory molecule that participates gene activation and protein function. Lysine lactylation (Kla) type post-translational modifications (PTMs) has been recently associated with chromatin remodeling; however, Kla histone...
ABSTRACT Toxoplasma gondii infects nucleated cells of warm-blooded animals and cause zoonotic toxoplasmosis. Lysine lactylation, as a novel post-translational modification, is essential for epigenetic regulation cellular processes, proteomic analyses have shown that lactylated proteins are involved in wide range biological processes including energy metabolism, gene regulation, protein biosynthesis. Additionally, lactylation prevalent T. , while its regulatory mechanisms not been fully...
Abstract Background: Pancreatic fistulae post distal pancreatectomy still leads to significant morbidity and if not properly managed, may lead mortality. The identification of risk factors effective management patients with pancreatic is important in the prevention these complications. Methods: There were 75 open consecutive pancreatectomies Department Surgery, Changi General Hospital from May 2001 2007. Results: indications for operation neuroendocrine tumours ( n = 15), adenocarcinoma 20),...
Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated anti-tumor and immunological activities a polysaccharide (BBP3-1) S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg−1·d−1) inhibited tumor growth rate by 73.4%. Moreover, this group, compared with model control, had shown an effect increasing both spleen thymus indices (p < 0.05),...
Malaria is one of the deadliest infectious diseases threatening half world population. With deterioration parasiticidal effect current antimalarials, novel approaches such as screening more specific inhibitors and targeted delivery drugs have been under intensive research. Herein, we prepare hollow mesoporous ferrite nanoparticles (HMFNs) 200 nm with ferromagnetic properties using a one-pot hydrothermal reaction. A magnetically drug-delivery system coloaded artemisinin in inner magnetite...
Trypanosoma brucei is the causative agent of African animal trypanosomosis, which mainly parasitizes blood host. Lipophosphoglycan (LPG), a polymer anchored to surface parasites, activates host immune response. In this study, we revealed that T. LPG stimulated neutrophils form neutrophil extracellular traps (NETs) and release reactive oxygen species (ROS). We further analyzed involvement toll-like receptor 2 (TLR2) 4 (TLR4) explored activation signaling pathway enzymes in response...
Diarrhea in piglets is one of the most important diseases and a significant cause death piglets. Preliminary studies have confirmed that taurine reduces rate index diarrhea induced by LPS. However, there still lack relevant information on specific target mechanism action taurine. Therefore, we investigated effects growth barrier functions intestine, microbiota composition, metabolite composition Eighteen male weaned were randomly divided into CON group (basal diet + standard saline...