A5101812028- Congenital gastrointestinal and neural anomalies
- Effects and risks of endocrine disrupting chemicals
- Intraocular Surgery and Lenses
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Renal and Vascular Pathologies
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Crystallization and Solubility Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Spinal Fractures and Fixation Techniques
- Pediatric Urology and Nephrology Studies
- Abdominal vascular conditions and treatments
- Retinopathy of Prematurity Studies
- Prostate Cancer Treatment and Research
- Birth, Development, and Health
- Phytochemicals and Antioxidant Activities
- Dialysis and Renal Disease Management
- Spinal Cord Injury Research
- Computational Drug Discovery Methods
- Aortic aneurysm repair treatments
- MRI in cancer diagnosis
- Spine and Intervertebral Disc Pathology
Wenzhou Medical University
2011-2025
Zhejiang Taizhou Hospital
2011-2024
United Imaging Healthcare (China)
2024
Hainan University
2024
Xiangya Hospital Central South University
2023
Central South University
2023
Hangzhou Medical College
2017-2022
Zhejiang Provincial People's Hospital
2015-2022
Weifang People's Hospital
2015-2022
Zaozhuang University
2022
The present study explored the effect of miR-200b on development diabetic retinopathy (DR) by targeting vascular endothelial growth factor A (VEGFA) gene. populations consisted 255 DR patients (case group) and 253 healthy people (control group), while expressions VEGFA mRNA were detected quantitative real-time PCR (qRT-PCR). Bioinformatics software dual-luciferase reporter assay used to confirm as a target gene Also, total 70 Wistar male rats selected randomly assigned into blank, normal...
Background: Continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) represent two common modes of (RRT) for elderly patients with acute kidney injury (AKI), but their clinical effectiveness is debated. This study aimed to compare the impact CRRT IHD on prognosis in AKI by analyzing data. Methods: The retrospective population included admitted Xiangya Hospital between 2018 2022, who required RRT AKI. Patients were separated into cohorts based original (CRRT or IHD). In...
Purpose This study aimed to evaluate the efficacy of a modified pneumatic retinopexy (PR) procedure for patients with rhegmatogenous retinal detachment (RRD), particularly those multiple-quadrant breaks that spanning more than three clock-hours arc. Methods prospective case series included ten eyes patients, all whom underwent PR surgery during hospitalization. The technique involved an intravitreal injection low concentration perfluoropropane (14% C 3 F 8 ) gas tamponade and head...
The aim of this study was the purification process polyphenols from Aronia melanocarpa (chokeberry), and parameters were optimised by adsorption desorption tests. By comparing ability chokeberry on six kinds macroporous resin, XAD-7 resin selected. Experiments prove that best static sample pH = 4.0 with 4 h adsorption; solvent is 95% ethanol (pH 7.0) 2 desorption. dynamic 9.3 bed volume (BV) loading amount at a feeding flow rate BV/h, washing column 5.8 BV water, followed subsequent elution...
Paederia foetida L. leaf (PFL) is recognized for its uric acid-lowering potential. However, the key compounds and their mechanisms of countering hyperuricemia remain unclear. In this study, bioaffinity ultrafiltration in combination with UPLC-ESI-QTrap-MS/MS was used to screen identify potential xanthine oxidase (XO) inhibitors PFL extract, possible interaction were investigated by molecular docking. The experimental results showed that extract exhibited excellent antioxidant anti-XO effect....
Abstract Solution crystallization is an important separation unit operation in active pharmaceutical ingredient production. Solvent one of the factors affecting crystal morphology. How to select/design suitable solvents still most urgent problems field. In this article, a framework for solvent design based on developed quantitative prediction model morphology proposed. First, molecular dynamics used predict solvents. Next, descriptors are selected by stepwise regression method. Then,...
This study was the first to investigate genetic abnormalities and structural dysplasia of anorectal malformations (ARMs) in male rats induced by di(n-butyl) phthalate (DBP). DBP administered timed-pregnant establish ARM rat model. The incidence ARMs offspring 39.5%. In neonatal period, decreased body weight anogenital distance were observed. general image histological analysis confirmed presence ARMs. Anatomical examination revealed solid organs (heart-lung, liver, spleen, kidney). decreases...
Background Simultaneous bilateral rhegmatogenous retinal detachment (RRD) is a rare and challenging condition in ophthalmology. This case report focuses on modified pneumatic retinopexy technique, designed to improve treatment outcomes for this difficult condition. Case presentation A 59-year-old male presented with decreased visual acuity his right eye one week. Examination revealed extensive the multiple superior breaks macula off, separated by approximately 3 clock hours. The left...
Abstract The polyphenol profile, antioxidant activity (particularly peroxyl radical-scavenging capacity (PSC) and cellular (CAA)) cytotoxicity of extracts from seven varieties blue honeysuckle were compared in this study. Moreover, an analysis correlations between individual profiles activities was also conducted. Seventeen components found the investigated extracts, with anthocyanins being prominent bioactive among polyphenols. Fruit peel contained higher concentrations to fruit pulp....
The clinical efficacy of pneumatic retinopexy (PR) using intravitreal pure air injection and laser photocoagulation for rhegmatogenous retinal detachment (RRD) remains unknown. Thirty-nine consecutive patients with RRD (39 eyes) were included in this prospective case series. All underwent two-step PR surgery containing during hospitalization. main outcomes best-corrected visual acuity (BCVA) primary anatomic success rates after treatment. mean follow-up was 18.3 ± 9.7 months, ranging from 6...
Germacrone a sesquiterpene is potential pharmacological agent with important medicinal applications. It anticancer and has been reported for activity against hepatoma cells breast cancer cells, additionally, it also shown anti-inflammatory, antioxidant, antifungal activity. Therefore, this study was designed to testify of germacrone terpenoid in human osteosarcoma along studying its effects autophagy induction, cell cycle disruption, downregulating the regulatory protein expressions...
An anthraquinone dye underwent supramolecular polymerization, affording 2D-monolayered nanosheets in a kinetically controlled state. The then transformed into hierarchically chiral aggregates thermodynamically step. unanticipated role played by pathway complexity was clearly unravelled this work, highlighting the diversified pathways polymerization of various building blocks.
The growth of pentacene on KCl(001) at submonolayer coverage was studied by dynamic scanning force microscopy. At coverages below one monolayer found to arrange in islands with an upright configuration. molecular arrangement resolved high-resolution images. In these images two different types patterns were observed, which switch repeatedly. addition, defects found, such as a vacancy and domain boundaries.
Mounting evidence has indicated the crucial role of Wnt5a in embryonic development including guts. However, involvement process anorectal malformations (ARMs) remains unclear. In this study, we examined expression during ARMs offspring di(n-butyl) phthalate (DBP)-treated pregnant rats. During neonatal period, was evaluated terminal rectum ARM offspring, non-ARM littermates and controls. Using real-time polymerase chain reaction (real-time PCR), western-blot analysis immunohistochemistry...
Objective: To evaluate the efficacy and safety of Hengli ® Chinese botulinum toxin type A (BTX-A; 100 U) in patients with overactive bladder. Methods: This study was a multicenter, randomized, double-blind, placebo-controlled trial who were inadequately managed anticholinergic medications. Eligible randomized 2:1 to receive intradetrusor injections BTX-A ( n = 144) or placebo 72). The primary endpoint change number daily micturition episodes at week 6 from baseline. secondary endpoints...