A5100730270- Renal and related cancers
- Renal cell carcinoma treatment
- Effects and risks of endocrine disrupting chemicals
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Epigenetics and DNA Methylation
- Congenital gastrointestinal and neural anomalies
- RNA modifications and cancer
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Neonatal Respiratory Health Research
- Bladder and Urothelial Cancer Treatments
- NF-κB Signaling Pathways
- Tuberous Sclerosis Complex Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Urinary and Genital Oncology Studies
- Renal Transplantation Outcomes and Treatments
- Genital Health and Disease
- Organ Transplantation Techniques and Outcomes
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Kidney Stones and Urolithiasis Treatments
- Pancreatic and Hepatic Oncology Research
Shanghai Jiao Tong University
2013-2025
Renji Hospital
2025
Shuguang Hospital
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Shanghai Municipal People's Government
2024
Shanghai First People's Hospital
1998-2022
Second Military Medical University
2009-2020
Shanghai Changzheng Hospital
2020
Jiangsu Province Hospital
2009-2012
Nanjing Medical University
2009-2012
Cancer cells that succeed in forming metastasis need to be reprogrammed evade immune surveillance and survive a new microenvironment. This is facilitated by metastatic niches are either postformed through reciprocal signaling between tumor local stromal or preformed as premetastatic before cell arrival. IL6/STAT3 aberrantly activated lung tumorigenesis metastasis, however, the roles mechanisms of action IL6 remain controversial. Here, we showed blockade intrinsic STAT3 suppressed...
Abstract GPRC5A is a G-protein–coupled receptor expressed in lung tissue but repressed most human cancers. Studies Gprc5a−/− mice have established its role as tumor-suppressor function this setting, the basis for has been obscure. Here, we report that functions negative modulator of EGFR signaling. Mouse tracheal epithelial cells (MTEC) from exhibited relative increase and downstream STAT3 signaling, whereas expression inhibited physically interacted with through transmembrane domain, which...
Chronic inflammation has been linked to promotion of tumorigenesis and metastasis in lung. However, due lack a relevant animal model for characterization, the underlying mechanism remains elusive. Lung tumor suppressor gene Gprc5a-knockout (ko) mice are susceptible lung inflammation, metastasis, which resembles pathological features human patients. Here, we showed that PTGES/PGE2 signaling was highly associated with Gprc5a-ko mice. Interestingly, Ptges-knockout mouse cells, although reduced...
Abstract Cellular glutathione (GSH) in lung cancer cells represents the most abundant antioxidant. GSH production is regulated not only by upregulated cystine/glutamate exchanger (xCT) but also involvement of glutamate transporters, specifically excitatory amino acid transporter 3 (EAAT3). Our prior research established that uptake via EAAT3 plays a pivotal role driving cystine through xCT, contributing to biosynthesis during tumorigenesis. Nevertheless, underlying mechanism governing...
// Shuli Liu 1, * , Dongxia Ye Dongliang Xu 2, 3 Yueling Liao Ling Zhang 1 Wenwen Yu Yanan Wang Yue He Jingzhou Hu Wenzheng Guo 2 Tong Beibei Sun 4 Hongyong Song Huijing Yin Jingyi 5 Yadi Wu Hanguang Zhu Binhua P. Zhou Jiong Deng 3, Zhiyuan Department of Oral and Maxillofacial–Head Neck Oncology, Ninth People’s Hospital, Shanghai Jiao University School Medicine, Shanghai, China Key Laboratory Cell Differentiation Apoptosis Chinese Minister Education, for Tumor Microenvironment...
G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade oral squamous cell carcinomas (OSCC) and overexpression gene inhibited the malignant phenotype in OSCC cells, suggesting also functions as suppressor cancer. However, molecular mechanisms underlying deficiency head neck carcinoma (HNSCC) are still unclear.In this...
GPRC5A, a retinoic acid induced gene, is preferentially expressed in lung tissue. Gprc5a gene deletion leads to spontaneous tumor development. However, the mechanism of Gprc5a‐mediated suppression not fully understood. Here we showed that MDM2, p53‐negative regulator, was dysregulated Gprc5a‐knockout (ko) mouse tracheal epithelial cells (KO‐MTEC) compared wild type ones. Targeting MDM2 1601—a Gprc5a‐ko derived cell line—and A549—human cancer cells, by inhibitor Nutlin‐3a or small hairpin RNA...
While initiation is established as a critical step in tumorigenesis, the identity of cell origin for lung adenocarcinoma and mechanism controlling susceptibility to remain elusive. Here we show that tumor suppressor Gprc5a-knockout (KO) mice are susceptible tumorigenesis. Bronchioalveolar stem cells (BASC) alveolar type 2 (AT2) were aberrantly expanded Gprc5a-KO mouse lungs compared with those wild-type (WT) mice, suggesting might confer by increasing lungs. BASCs from (KO-BASC) exhibited...
Susceptibility to acute lung injury (ALI) and respiratory distress syndrome (ARDS) varies greatly among patients in sepsis/septic shock. The genetic biochemical reasons for the difference are not fully understood. G protein coupled receptor family C group 5 member A (GPRC5A), a retinoic acid target gene, is predominately expressed bronchioalveolar epithelium of lung. We hypothesized that Gprc5a important controlling susceptibility ALI or ARDS. In this study, we examined wild-type...
This study was the first to investigate genetic abnormalities and structural dysplasia of anorectal malformations (ARMs) in male rats induced by di(n-butyl) phthalate (DBP). DBP administered timed-pregnant establish ARM rat model. The incidence ARMs offspring 39.5%. In neonatal period, decreased body weight anogenital distance were observed. general image histological analysis confirmed presence ARMs. Anatomical examination revealed solid organs (heart-lung, liver, spleen, kidney). decreases...
// Xiaofei Wang 1, 2, * , Dongliang Xu 3, 4, Yueling Liao Shuangshuang Zhong 4 Hongyong Song Beibei Sun 5 Binhua P. Zhou 6 Jiong Deng Baohui Han 1 Department of Pulmonary Medicine, Shanghai Chest Hospital, Jiao Tong University, Shanghai, China 2 Ruijin School 3 Key Laboratory Cell Differentiation and Apoptosis Chinese Minister Education, Pathophysiology, for Tumor Microenvironment Inflammation, University Translation Medicine Center, Molecular Cellular Biochemistry, Markey Cancer Kentucky...
Autophagy plays key roles in the development of acute pancreatitis (AP) and regulation impaired autophagy has therapeutic potential. The objective present study was to investigate whether pharmacological inhibition could ameliorate AP mice examine underlying mechanisms. In current study, by imaging-based high-throughput screening, a novel spautin-1 derivative spautin-A41 identified as potent inhibitor. Mice treated with were resistant cerulein-induced elevation serum pancreatic enzyme...
Some published evidence has revealed that the dendritic cells can interact with pathogens exist in inner foreskin. This information provides a new vision could play role through redundant prepuce; numerous studies have failed to find prostates of patients who had chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, no reported an association between foreskin length and CP/CPPS. Hence, we conducted retrospective case-control study clinical data from 322 CP/CPPS (case group)...