A5100746075- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Kidney Stones and Urolithiasis Treatments
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Head and Neck Cancer Studies
- Hormonal and reproductive studies
- DNA Repair Mechanisms
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- Plant-based Medicinal Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- thermodynamics and calorimetric analyses
- Cell Image Analysis Techniques
- Abdominal Surgery and Complications
- Cancer, Lipids, and Metabolism
Chinese Institute for Brain Research
2025
Beijing Normal University
2025
Beijing Tsinghua Chang Gung Hospital
2024
Tsinghua University
2024
Pfizer (United States)
2022-2024
Shanghai Jiao Tong University
2011-2022
Shanghai First People's Hospital
2009-2022
Sichuan University
2022
Nanjing Medical University
2017
Linyi People's Hospital
2012
Objectives To compare the safety and efficacy of conventional monopolar transurethral resection bladder tumour (TURBT) 2-micron continuous-wave laser (2-µm laser) techniques in management multiple nonmuscle-invasive cancer (NMIBC), to investigate long-term effects on recurrence. Methods Patients with NMIBC were randomized receive TURBT or 2-µm a nonblinded manner. All patients received intravesical chemotherapy epirubicin (40 mg/40 ml) for 8 weeks, beginning 1 week after surgery, followed...
We compared the safety and efficacy of percutaneous antegrade ureterolithotripsy with retrograde for large impacted proximal ureter stones in a prospective randomized manner.A total 91 patients ureteral stones, defined as >1 cm size located between ureteropelvic junction lower border fourth lumbar vertebra, were prospectively (44) or (47) ureterolithotripsy. Failure procedure (conversion to an open procedure), intraoperative postoperative morbidity, operative time, hospital stay, stone...
Tumor-associated macrophages (TAMs) are major innate immune cells that play crucial roles in prostate cancer onset and progression. Recently, increasing evidence has suggested elevated N6-adenine methylation of mRNA is observed tissues closely associated with a poor prognosis. However, its role cancer-associated remains poorly understood. Here, we showed downregulation METTL3 TAMs modulated toward an M2-like phenotype this modulation was mediated by activation STAT6. In addition, our data...
Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in surgery. They venous clusters formed by congestion, expansion, flexion of plexus lower part rectum. Mixed hemorrhoids bleed easily recurrently, this can result severe anemia. Hence, they may have a negative effect on health patient surgical treatment is required. Milligan-Morgan hemorrhoidectomy has been widely used since 1937 for grade III IV hemorrhoids. However, patients experience different...
Abstract The objective of the study was to evaluate fluid-electrolyte and renal pelvic pressure (RPP) changes during ureteroscopic lithotripsy. Fifteen patients were detected with residual ureteral calculi after minimally invasive percutaneous nephrolithotomy (MPCNL), distal ureter in three, midureter four, proximal eight. RPP measured via nephrostomy tube by urodynamic at irrigation pressures 50, 100 200 mmHg. Haemoglobin (Hb), haematocrit (Hct), blood urea mitrogen (BUN), creatinine (Cre),...
Abstract Background and Objectives We have reported the efficacy safety of 2‐micrometer continuous wave laser resection non‐muscle‐invasive bladder tumor (NMIVBC) (World J Urology 2010;28:157–161). In this study, we evaluated use in combination with intravesical instillation epirubicin for treatment multiple NMIVBC. Materials Methods From September 2007 to April 2008, sixty patients NMIVBC were included study (44 cases low grade papillary urothelial carcinoma, 10 high six neoplasm malignant...
Abstract Genotoxicity testing guidelines require the assessment of clastogenic and aneugenic potential compounds. While in vitro micronucleus assays detect both types endpoints, it requires labor‐intensive microscopic scoring does not discriminate between two modes actions. Here, we present a novel high‐content imaging platform A375 human cells that addresses need for rapid while providing additional mechanistic information. We evaluated new with 12 compounds, three compounds from each class...
The wound-healing process is very important for reducing complications after thulium laser resection of the prostate (TmLRP). retinoic acid (RA) signaling pathway has been well studied in skin and other organs. goals this study were to identify role RA repair TmLRP investigate molecular mechanism process.Retinoic receptors (RARs) present prostate, their expression was increased TmLRP. RARβ expressed macrophages may be related stromal cells process. In vitro, enhanced function...
Abstract Previously, we introduced an alternative adherent A375 cell line for clastogenicity and aneugenicity testing using a high content imaging platform. To further characterize the performance of cells, investigated sensitivity specificity TK6 cells by directly comparing micronucleus (MN) induction, cytotoxicity (relative counts, viability, apoptosis), (γH2AX), aneuploidy markers (pH 3, MPM‐2, polyploidy) flow cytometric methods. We evaluated 14 compounds across different mechanisms...