A5100698032- Phytochemical and Pharmacological Studies
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- Ubiquitin and proteasome pathways
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Gut microbiota and health
- Glioma Diagnosis and Treatment
- Ethics in Clinical Research
- Cardiac Fibrosis and Remodeling
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Lipoproteins and Cardiovascular Health
- Ethics and Legal Issues in Pediatric Healthcare
- Medication Adherence and Compliance
- 3D Printing in Biomedical Research
- Cardiovascular and Diving-Related Complications
- Childhood Cancer Survivors' Quality of Life
- Extracellular vesicles in disease
- Connexins and lens biology
- Medicinal plant effects and applications
- Erythropoietin and Anemia Treatment
- Brain Tumor Detection and Classification
- Cerebrovascular and Carotid Artery Diseases
Zhejiang Chinese Medical University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Harbin Medical University
2021-2025
Second Affiliated Hospital of Harbin Medical University
2023-2025
Beijing Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Guangdong Academy of Medical Sciences
2021-2024
Guangdong Provincial People's Hospital
2021-2024
Southern Medical University
2024
Sichuan University
2019-2024
<h3>Importance</h3> Extremely preterm (EP) infants frequently receive opioids and/or benzodiazepines, but these drugs' association with neurodevelopmental outcomes is poorly understood. <h3>Objectives</h3> To describe the use of and benzodiazepines in EP during neonatal intensive care unit (NICU) hospitalization to explore at 2 years' corrected age. <h3>Design, Setting, Participants</h3> This cohort study was a secondary analysis data from Preterm Erythropoietin Neuroprotection (PENUT)...
<h3>Importance</h3> It remains poorly understood how parents decide whether to enroll a child in neonatal clinical trial. This is particularly true for from racial or ethnic minority populations. Understanding factors associated with enrollment decisions may improve recruitment processes families, increase rates, and decrease disparities research participation. <h3>Objective</h3> To assess differences parental between who enrolled their infant those declined randomized <h3>Design, Setting,...
Abstract The aging of the population is a global concern. In post-COVID-19 pandemic era, there are no effective methods to identify acceleration due infection. this study, we conducted whole-transcriptome sequencing on peripheral blood samples from 35 healthy individuals (22-88 years old). By analysing changes in mRNA, lncRNA, and miRNA expression, investigated characteristics transcriptome alterations during process. ceRNA networks were constructed, ten genes (CD248, PHGDH, SFXN2, MXRA8,...
Ischemic tolerance renders the brain resistant to ischemia-reperfusion (I/R) injury as a result of activation endogenous adaptive responses triggered by various types preconditioning. The complex underlying metabolic mechanisms responsible for neuroprotection cerebral ischemic preconditioning (IPC) remain elusive. Herein, gas chromatography-mass spectrometry (GC-MS) technique was applied delineate dynamic changes metabolome in rodent model stroke (transient occlusion middle artery, tMCAO),...
Background Administrative data are frequently used in stroke research. Ensuring accurate identification of patients who had an ischaemic stroke, and those receiving thrombolysis endovascular thrombectomy (EVT) is critical to ensure representativeness generalisability. We examined differences patient samples based on mode identification, propose a strategy for future procedure large administrative databases. Methods non-public from the state California identify all discharged emergency...
This meta-analysis aims to elucidate the role of probiotics in regulating blood lipid profiles adults with overweight or obesity. The Pubmed, Cochrane Library, Scopus and Web Science were used search for relevant randomized controlled trials (RCTs) published before August 2021. effects probiotic intervention assessed by total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) high-density (HDL-C) levels. outcome data synthesized using standardized mean differences (SMDs)....
Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in surgery. They venous clusters formed by congestion, expansion, flexion of plexus lower part rectum. Mixed hemorrhoids bleed easily recurrently, this can result severe anemia. Hence, they may have a negative effect on health patient surgical treatment is required. Milligan-Morgan hemorrhoidectomy has been widely used since 1937 for grade III IV hemorrhoids. However, patients experience different...
Heart failure (HF) is one of the main comorbidities in patients receiving maintenance hemodialysis (HD). Sacubitril/valsartan (SAC/VAL) widely used HF with reduced ejection fraction (HFrEF) or mid-range (HFmrEF). However, pharmacokinetic (PK) and pharmacodynamic properties SAC/VAL HD remain uncertain.This study aimed to analyze efficacy PK HFrEF HFmrEF.HD HFmrEF were treated 50 100 mg twice a day (BID) concentrations valsartan LBQ657 (active metabolite SAC) determined by high-performance...
Abstract Background Atopic dermatitis (AD) is a worldwide chronic skin disease which burden public health. Sea buckthorn (SBT) ( Hippophae rhamnoides L., Elaeagnaceae) oil, as traditional herbal medicine, has been used for treatment many years. The effects of SBT oil on AD mouse model induced by repeated administration 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice was evaluated this study. Methods Mice were divided into four groups including the normal control group, group treated with (5...
Cardiac fibrosis is a common pathological cardiac remodeling in variety of heart diseases, characterized by the activation fibroblasts.Our previous study uncovered that promyelocytic leukemia protein (PML)-associated SUMO processes new regulator hypertrophy and failure.The present aimed to explore role PML fibroblasts activation.Here we found significantly upregulated fibrotic tissue activated treated with transforming growth factor-β1 (TGF-β1).Gain-and loss-of-function experiments showed...
Abstract Background There are significant racial and ethnic disparities in receipt of reperfusion interventions for acute ischemic stroke. Our objective was to determine whether there access stroke center care by race or ethnicity that help explain differences therapy understand interhospital patient transfer plays a role improving access. Methods Using statewide administrating data including all emergency department hospital discharges California from 2010 2017, we identified patients....
ABSTRACT Inconsistent enrollment among hospitals for neonatal clinical trials may lead to study populations that are not representative of the patient population in intensive care unit. The High‐Dose Erythropoietin Asphyxia and Encephalopathy (HEAL) trial was a multisite randomized investigating erythropoietin as neuroprotective treatment term infants (those born between 37 42 complete weeks) with hypoxic ischemic encephalopathy. Substantial variability noted rate by hospital. We developed...
Retinoblastoma (RB) is an intraocular malignancy that mainly affects young children. Previous reports have demonstrated mutations or the inactivation of RB1 gene were main cause RB; however, disruption intracellular signaling pathways following deficiency requires further investigation. Based on Gene Expression Omnibus data and bioinformatics prediction, present study aimed to investigate microRNA (miR)‑338‑3p/neuro‑oncological ventral antigen 1 (NOVA1) axis in RB. Subsequently,...
The principal voltage-gated Na+ channel, NaV1.5 governs heart excitability and conduction. dysregulation is responsible for ventricular arrhythmias subsequent sudden cardiac death (SCD) in post-infarct hearts. transcription factor Meis1 performs a significant role determining differentiation fate regenerative capability of cardiomyocytes. However, the functions ischemic following myocardial infarction (MI) are still largely undefined.Here we aimed to study whether could act as key regulator...
Oxidative stress degrades oocytes during in vitro maturation (IVM). Catalpol, a well-known iridoid glycoside, exhibits antioxidant, anti-inflammatory, and antihyperglycemic effects. In this study, catalpol supplementation was tested on porcine oocyte IVM its mechanisms. Corticalgranule (GC) distribution, mitochondrial function, antioxidant capacity, DNA damage degree, real-time quantitative polymerase chain reaction were used to confirm the effects of 10 μmol/L medium IVM. Catalpol treatment...
As the incidence of senile dementia continues to increase, researches on Alzheimer’s disease (AD) have become more and important. Several studies reported that there is a close relationship between AD aging. Some researchers even pointed out if we wanted understand in depth, mechanisms based accelerated aging must be studied. Nowadays, machine learning techniques been utilized deal with large complex profiles, thus playing an important role (i.e., modelling biological systems, identifying...
Cutaneous melanoma is one of the most common malignant skin tumors and advanced usually associated with a poor prognosis. In current study, we demonstrated tumor suppressing role epithelial membrane protein-2 (EMP2) by inducing apoptosis in A375 human cell line. Mechanistically, low expression EMP2 partially due to autophagic protein degradation mediated mTOR pathway. These results suggest there regulation autophagy as well levels might be an interesting novel targeted therapeutic strategy...
To examine the current situation of potentially inappropriate medicines (PIM) for treatment chronicity in older patients and whether were included 22nd World Health Organization (WHO) Model List Essential Medicines (EMLs), China National list (China EMLs), or supplementary essential Guizhou Province 2018 (Guizhou EMLs) through real world data, so as to promote development lists suitable provide a reference revision reduce adverse effects, drug-induced diseases even possible death due use...