A5100406831- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Photoacoustic and Ultrasonic Imaging
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Ultrasound and Hyperthermia Applications
- Plant biochemistry and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Inflammation biomarkers and pathways
- Electron Spin Resonance Studies
- COVID-19 diagnosis using AI
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Tea Polyphenols and Effects
- Cell death mechanisms and regulation
- Phytoestrogen effects and research
- Bioactive Natural Diterpenoids Research
- Berberine and alkaloids research
Soochow University
2020-2024
Shenyang Agricultural University
2023-2024
First Hospital of China Medical University
2024
China Medical University
2024
Hebei Agricultural University
2024
University of Jinan
2023
Wuhan University of Science and Technology
2023
Henan University of Science and Technology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
Chengdu Third People's Hospital
2022
Carotenoids are one of the most widespread groups naturally occurring pigments with extensive applications in food, nutraceutical, pharmaceutical, and cosmetic industries. Sporobolomyces pararoseus is a well-studied oleaginous red yeast that has attracted rising interest as an alternative source high-value-added carotenoids, consisting β-carotene, torulene, torularhodin. Here, effect different concentrations H2O2 treatments on carotenoid contents S. CJR was investigated. The results showed...
Abstract This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of signaling in mice attenuated dextran sulfate sodium (DSS)-induced damage epithelium markedly reduced development an azoxymethane/DSS model colitis-associated cancer. A target gene, PLET1 (a progenitor cell marker involved wound healing), was highly induced DSS-treated tissues tumors IL-17RC–dependent manner. expression LGR5+ epithelial cells after DSS treatment....
Due to high proliferative capacity, multipotent differentiation, immunomodulatory abilities, and lack of ethical concerns, dental pulp stem cells (DPSCs) are promising candidates for clinical application. Currently, research on DPSCs is in its early stages. The reason the failure obtain clinically effective results may be problems with production process DPSCs. different preparation methods reagent formulations DPSCs, cell characteristics affected lead inconsistent experimental results....
As a traditional Chinese medicine, Gynochthodes officinalis (F.C.How) Razafim. & B.Bremer (G. officinalis) has been historically as tonics to treat impotence. Fermentation is an ancient processing method for medicine. Whether fermentation affects the therapeutic effects of G. on diabetic erectile dysfunction so far remained unknown.In this research, we aim determine effect fermented or unfermented root extract diabetes mellitus-induced (DMED) and potential mechanisms.Candida sp. B5,...
Protecting the body from radiation damage is a huge medical challenge. Amifostine and curcumin are both effective radioprotectants, but their use has been greatly restricted due to various reasons including low bioavailability. Nanoscale drug delivery systems of poly(ethylene glycol)–poly(ε-caprolactone) copolymers can improve bioavailability drugs excellent biocompatibility, biodegradability, long circulation characteristics. In this study, new reactive oxygen species-sensitive nanocarrier...
Although clinical outcomes of CLL have improved with the use BCL-2 inhibitor, ABT-199, acquired resistance eventually occurs in many cases, which leads to disease progression. Thus, understanding mechanisms that mediate this relapse is important design therapies. Herein, we report cytokine IFN-γ, secreted by dysfunctional T cells, enhanced cells ABT-199. IFN-γ stimulation significantly increased expression BCL-2, MCL-1 and BCL-xL. Blocking JAK1/2-STAT3 signaling pathway impaired these...
We planned to investigate the protective effect of soy isoflavone (SIF) genistein (GEN), and daidzein (DAI), their mixed solution against carbaryl-induced toxicity in PC12 cells. cells were exposed carbaryl, pretreated, co-treatment, or posttreatment with three different SIF solutions for indicated times. Exposure resulted a better survival cell morphology which subjected carbaryl toxicity. Treatment was also found reduce malondialdehyde content, superoxide dismutase inhibitory rate,...
The risk of radiation damage has increased with the rapid development nuclear technology and radiotherapy. Hence, research on radioprotective agents is utmost importance. In present study, a novel aminothiol compound 12, containing linear alkylamino backbone three terminal thiols, was synthesized. Owing to appropriate capped groups in chains, it an improved permeability oral bioavailability compared other agents. Oral administration 12 survival mice that received lethal doses γ ‐irradiation....
The effect of taurine (TAU) as a specific regulatory mediator on pancreatic function in obese rats induced by high-fat-high-glucose (HFHG) diet was investigated. We fed male Sprague-Dawley under different conditions, namely the control, HFHG, TAU, and HFHG + TAU treatment groups for 4 months. Compared with group, supplementation significantly reduced malondialdehyde levels increased superoxide dismutase, total antioxidant capacity, glutathione rat pancreas. In addition, decreased level...
Purpose With the development of nuclear technology and radiotherapy, risk radiation injury has been increasing. Therefore, it is important to find an effective radiation-protective agent. In this study, we designed synthesized a novel compound called 8, which radioprotective effect mechanism were studied.Materials methods Before being exposed ionizing radiation, mice pretreated with 8. The 30-day mortality assay, hematoxylin–eosin staining, immunohistochemistry staining assay performed...