A5100668552- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Effects of Radiation Exposure
- Autophagy in Disease and Therapy
- Metal-Organic Frameworks: Synthesis and Applications
- Cell death mechanisms and regulation
- Radiation Therapy and Dosimetry
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Myopathies and Dermatomyositis
- Stroke Rehabilitation and Recovery
- Systemic Lupus Erythematosus Research
- Vitamin C and Antioxidants Research
- Traditional Chinese Medicine Analysis
- Nanomaterials for catalytic reactions
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Molecular Sensors and Ion Detection
- Antioxidant Activity and Oxidative Stress
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Intraoperative Neuromonitoring and Anesthetic Effects
- Physiological and biochemical adaptations
- Influenza Virus Research Studies
Hangzhou First People's Hospital
2024
Northeastern University
2024
Guangdong Laboratory Animals Monitoring Institute
2020-2024
Zhejiang University
2023-2024
Westlake University
2024
Weatherford College
2024
Chongqing Medical University
2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Dalian Medical University
2024
Abstract Background The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results late-onset Parkinson’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with pathogenesis of PD. Chronic periodontitis is a common type peripheral inflammation, which Porphyromonas gingivalis (Pg), most bacterium causing chronic periodontitis, can cause alteration microbiota. It not known whether Pg-induced dysbiosis plays role pathophysiology Methods In this study,...
To investigate the value of combined detection neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein level (CRP) in diagnosis COVID-19. A total 191 patients with COVID-19 were recruited at Third Hospital Wuhan from 21 January 2020 to 20 February 2020. Fifty healthy volunteers randomly selected as control group. Age, gender, white blood cell count (WBC), CRP, lymphocyte percentage, NLR extracted. Quantitative clinical characteristics laboratory values compared between groups. Risk...
The present study aimed to elucidate the mechanism of dietary betaine, as a lipid-lowering substance, on regulation lipid metabolism and inflammation in juvenile black seabream ( Acanthopagrus schlegelii ) fed high fat diet. An 8-week feeding trial was conducted with an initial weight 8.39 ± 0.01g four isonitrogenous diets including Control, medium-fat diet (11%); HFD, high-fat (17%); HFD supplemented two levels (10 20 g/kg) HFD+B1 HFD+B2, respectively. SGR FE fish HFD+B2 were significantly...
Purpose: To investigate the efficacy of intravitreal administration resveratrol (RSV) in a microbead-induced high intraocular pressure (IOP) murine model for glaucoma. Methods: Experiments were performed using adult C57BL/6JJcl mice. Polystyrene microbeads injected into anterior chamber to induce IOP elevation. Retinal flat-mounts and sections assessed by immunohistochemistry detect expression reactive oxygen species acetyl-p53 retinal ganglion cells (RGCs), brain-derived neurotrophic factor...
The oral delivery of genistein (GEN) is hindered by its low bioavailability. tetramethylpyrazine (TMP or ligustrazine) faced with physical instability challenges due to high sublimation tendency. We tackled respective the two drugs forming a cocrystal. GEN-TMP cocrystal exhibits significantly reduced tendency than TMP and significant enhancement in both vitro release rate bioavailability rats GEN. Thus, cocrystallization simultaneously improves pharmaceutical properties parent drugs.
Abstract Background Machado-Joseph disease is the most common autosomal dominant hereditary ataxia worldwide without effective treatment. Mesenchymal stem cells (MSCs) could slow progression, but side effects limited their clinical application. Besides, MSC-derived exosomes exerted similar efficacy and have many advantages over MSCs. The aim of this study was to examine in YACMJD84.2 mice. Methods Rotarod performance evaluated every 2 weeks after a presymptomatic administration intravenous...
In liver transplantation (LT), although various immunosuppressants have been used in clinical practice, acute rejection remains a common complication that significantly shortens recipient survival. recent years, manipulating immune tolerance has regarded as one of the promising solutions to rejection. Autophagy, an evolutionarily conserved protein degradation system, reported be involved and may target establish tolerance. However, role autophagy reaction after LT not elucidated. Here, we...
Connective tissue disease (CTD) is a heterogeneous group of chronic inflammatory autoimmune disorders derived from systemically auto-immunological deregulation. CTD may affect cardiac structures through multiple pathophysiological mechanisms, and subclinical injury common. Heart failure (HF) one the common complications in these patients.
We report on the thiol-ene chemistry guided preparation of a novel thiolated polymeric nanocomposite involving polyaniline (PANI), functionalized thiol, e.g., sulfur-rich 2,5-dimercapto-1,3,4-thiadiazole (DMcT), and multiwalled carbon nanotubes (MWCNTs) for sensitive differential pulse anodic stripping voltammetric determination Cd(2+) Pb(2+) glassy electrode (GCE). Briefly, reaction thiol with oxidized PANI that was chemically synthesized in presence solution-dispersed acidified MWCNTs...