A5101575899- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Photoreceptor and optogenetics research
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Sexual function and dysfunction studies
- Photosynthetic Processes and Mechanisms
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Neurogenetic and Muscular Disorders Research
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Disaster Management and Resilience
- Light effects on plants
- Bee Products Chemical Analysis
- Artificial Intelligence in Healthcare and Education
- Planarian Biology and Electrostimulation
- Genomics and Rare Diseases
China Rehabilitation Research Center
2022-2024
Capital Medical University
2022-2024
Central South University
2023
Sun Yat-sen University
2013-2020
The First Affiliated Hospital, Sun Yat-sen University
2013-2020
Objective To evaluate the efficacy and safety of a wearable, smartphone‐controlled, rechargeable transcutaneous tibial nerve stimulation (TTNS) device in patients with overactive bladder (OAB). Patients Methods This multicentre, prospective, single‐blind, randomised clinical trial included eligible OAB symptoms who were randomly assigned to group or sham group. The primary outcome was change from baseline voiding frequency/24 h after 4 weeks treatment. secondary outcomes changes diary...
Abstract Background Machado-Joseph disease is the most common autosomal dominant hereditary ataxia worldwide without effective treatment. Mesenchymal stem cells (MSCs) could slow progression, but side effects limited their clinical application. Besides, MSC-derived exosomes exerted similar efficacy and have many advantages over MSCs. The aim of this study was to examine in YACMJD84.2 mice. Methods Rotarod performance evaluated every 2 weeks after a presymptomatic administration intravenous...
Purpose To use functional near-infrared spectroscopy (fNIRS) to identify changes in brain activity during tibial nerve stimulation (TNS) patients with overactive bladder (OAB) responsive therapy. Methods Eighteen refractory idiopathic OAB were recruited consecutively for this pilot study. At baseline, all completed 3 days voiding diary, Quality-of-Life score, Perception-of-Bladder-Condition, and Overactive-Bladder-Symptom score. Then 4 region-of-interest (ROI) fNIRS scans blocks conducted...
Optogenetics is a rapidly developing field combining optics and genetics, with promising applications in neuroscience beyond. However, there currently lack of bibliometric analyses examining publications this area.Publications on optogenetics were gathered from the Web Science Core Collection Database. A quantitative analysis was conducted to gain insights into annual scientific output, distribution authors, journals, subject categories, countries, institutions. Additionally, qualitative...
Purpose: To explore whether stimulation of C-fibers in tibial nerves can induce bladder inhibition by optogenetic transdermal illumination. Methods: Ten rats were injected with AAV2/6-hSyn-ChR2(H134R)-EYFP into the nerves. Transurethral cystometry was performed 4 weeks after virus injection. Illumination (473-nm blue light at 100 mW) fiber positioned above right hind paw near ankle. The transmission efficiency examined a laser power meter. effects on compared before and illumination infused...
Abstract Purpose To establish typical value ranges (TVRs) of the air‐charged catheter (ACC) system, and analyze signal patterns (TSPs) cough under different bladder volumes for quality control a urodynamic study using ACC system. Materials Methods The traces 1977 patients with neurogenic (NB) were analyzed intravesical pressure (p ves ), abdominal abd detrusor det ) in test at our center from July 2017 to December 2021. p signals described classified. postures analyzed. Results 50% range...
Abstract Objectives To explore the inhibitory effects of a novel, smartphone‐controlled, and wearable tibial nerve stimulation device on nonnociceptive nociceptive bladder reflexes in anesthetized cats to compare stimulus results two current waveforms outputted by this new stimulator. Materials Methods A intelligent stimulator was put ankles 14 controlled mobile application. Cystometrograms (CMGs) were performed repeatedly infusing 0.9% normal saline (NS) 0.5% acetic acid (AA) through...
Purpose To evaluate the preliminary efficacy, safety, and acceptability of a transcutaneous tibial nerve stimulation (TTNS) device in overactive bladder (OAB) patients. Methods Twenty OAB patients who failed with conservative treatments were recruited consecutively. All received 60 min daily unilateral for 4 weeks using smart wearable stimulations at 20 Hz frequency, 200 μs pulse width. symptoms observed baseline week 4, 3-days voiding diary, symptom score (OABSS), perception condition...
The spinocerebellar ataxia·type 3 (SCA3),which belongs to the group of polyglutamine repeat (polyQ) diseases,is most frequent form among autosomal dominantly inherited ataxias in China.Ataxin-3,encoded by SCA3 gene ( atxn3 ),is a ubiqitin-bingding protein and involved mornitoring degenaration proteins its deubiquitylation activity.The expanded ataxin-3 is aggregative potential forms aggresomes or inclusions recruiting other proteins.The mutant compromises regulation transcription,challenges...
To assess the inter-observer and intra-observer reliability of magnetic resonance urography (MRU)-upper urinary tract dilation (UUTD) grading system.A total 40 patients with a diagnosis NB were enrolled in this study. The images assembled an electronic presentation randomly. presentations reviewed graded by 4 junior senior urologists. One week later, randomized again reassessed. was estimated Kendall's coefficient concordance intra-class correlation (ICC), weighted Cohen's kappa.The strength...