A5101505511- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Aldose Reductase and Taurine
- Tissue Engineering and Regenerative Medicine
- Urinary Tract Infections Management
- Bladder and Urothelial Cancer Treatments
- Hormonal and reproductive studies
- Advanced Glycation End Products research
- Spinal Cord Injury Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Pelvic and Acetabular Injuries
- Kidney Stones and Urolithiasis Treatments
- Connexins and lens biology
- Pancreatitis Pathology and Treatment
- Prostate Cancer Treatment and Research
- Advanced Proteomics Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Reproductive Biology and Fertility
- Nerve injury and regeneration
- Tea Polyphenols and Effects
- Intraocular Surgery and Lenses
Second Affiliated Hospital of Nanjing Medical University
2014-2024
Tianjin University
2022
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Nanjing Medical University
2013-2014
Jiangsu Province Hospital
2014
Nanjing Drum Tower Hospital
2011
Nanjing University
2006
Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau explored to be associated with increased drug resistance various kinds of cancers. We found that the was expressed prostate cancer cell lines DU145 and PC-3. also reported recurrent cells after docetaxel treatment have higher levels protein tau. In vitro, inactivation by gene knockdown suppressed proliferation sensitized cytotoxicity. Also, our results demonstrated PI3K/Akt/mTOR pathway...
Dorsal root ganglion (DRG) neurons, which are sensitive to oxidative stress due their anatomical and structural characteristics, play a complex role in the initiation progression of diabetic bladder neuropathy. We investigated hypothesis that antioxidant antiapoptotic effects CGRP may be partly related expression Nrf2 HO-1, via phosphatidylinositol 3-kinase (PI3K)/AKT pathway, thus reducing apoptosis responses. This study shows activates PI3K/AKT thereby inducing increased HO-1 resulting...
Objective To evaluate the efficacy and safety of a wearable, smartphone‐controlled, rechargeable transcutaneous tibial nerve stimulation (TTNS) device in patients with overactive bladder (OAB). Patients Methods This multicentre, prospective, single‐blind, randomised clinical trial included eligible OAB symptoms who were randomly assigned to group or sham group. The primary outcome was change from baseline voiding frequency/24 h after 4 weeks treatment. secondary outcomes changes diary...
Interstitial cystitis (IC) is a clinical syndrome characterized by frequency, urgency, and bladder pain or pelvic pain; however, the underlying pathophysiological mechanisms diagnostic markers are unknown. In this study, microbiome metabolome analysis were used to explain urine signatures of IC patients. Urine samples from 20 patients 22 control groups analyzed using 16S rRNA sequence liquid chromatography coupled with mass spectrometry. Four opportunistic pathogen genera, including...
The objective of this study was to investigate the effects and mechanism Transcutaneous Electrical Nerve Stimulation (TENS) on diabetic cytopathy (DCP) in bladder. A total 45 rats were randomly divided into diabetes mellitus (DM)/TENS group (n = 15), DM 15) control 15). DM/TENS TENS groups electronically stimulated (stimulating parameters: intensity-31 V, frequency-31 Hz, duration stimulation 15 min) for three weeks. Bladder histology, urodynamics contractile responses field carbachol...
Aim: This study aimed to determine whether nuclear factor erythroid 2-related 2 antagonized the oxidative stress induced by di- N-butylphthalate (DBP) in testicular Leydig cells. Methods: Mouse TM3 cells were treated with Nrf2 knockdown (KD) or overexpression presence and absence of DBP. Oxidative profiles examined. target antioxidant genes studied, effects inducer sulphoraphane (SFN) tested. Results: DBP intracellular a similar extent KD. Expression protein levels increased together its...
Objective . To investigate the protective effect and molecular mechanism of nuclear factor E2‐related 2 (Nrf2) pathway in interstitial cystitis (IC). Methods We established a mouse model IC by cyclophosphamide (CYP) wild‐type mice Nrf2 gene knockout mice. examined histological functional alterations, changes oxidative stress markers, expression antioxidant genes downstream pathway. Results After CYP administration, showed urinary frequency urgency, pain sensitization, decreased...
Diabetic cystopathy (DCP) is one of the most common complications diabetes mellitus (DM). A previous study reported that caffeine may improve bladder dysfunction in rats with DM. The aim present was to investigate mechanisms behind capacity for function Sprague Dawley were divided into four groups: control, caffeine, DM and plus treatment (DM + caffeine). Bladder measured by urodynamic analyses. levels nerve growth factor (NGF), brain‑derived neurotrophic (BDNF) calcitonin gene‑related...
Objective: To investigate the risk factors of systemic inflammatory response syndrome (SIRS) in patients undergoing flexible ureteroscopic lithotripsy based on enhanced recovery after surgery (ERAS). Methods: The clinical data 243 kidney stone cases who underwent ERAS First Affiliated Hospital Wannan Medical College from January 2016 to December 2017 were analyzed retrospectively. divided into two groups according whether they had SIRS surgery: group (26 cases) and non-SIRS (217 cases). age,...
Diabetic cystopathy (DCP) is a chronic complication of diabetes mainly within the submucosal and muscular layers bladder due to hyperglycemia-induced ischemia. As no effective therapies are currently available, administration optimized mesenchymal stem cells (MSCs) provides potential treatment DCP. Thus far, new strategy, such as genetic modification MSCs, has been developed shown promising outcomes various disorders. This study was conducted using integrin-linked kinase (ILK) gene-modified...
To evaluate the efficacy and safety of a novel remote programming sacral neuromodulation (SNM) system (BetterStim system) in treatment patients with refractory overactive bladder (OAB) for 3 years.A total 8 centers China enrolled 84 OAB. Following test stimulation 70 underwent implantation using BetterStim. All returned follow-up at 6 months postoperatively. After that, visits were conducted by telephone. Outcomes voiding diaries, symptom score (OABSS), questionnaires regarding OAB-related...
Abstract This study aimed to evaluate differences in the clinical outcomes of different sacral neuromodulation systems (InterStim and BetterStim) used treatment overactive bladder. Data from a previously established database China (the InterStim system) 2020 trial BetterStim system were screened. Patients with bladder undergoing stage II implanted pulse generator implantation selected for analysis divided into groups. Voiding diaries subjective scores obtained preoperatively, after I...
ObjectiveTo evaluate artificial reflex arcs for micturition using urodynamics and electrophysiological recordings.DesignSixteen beagles were equally randomly divided into two groups.MethodsIn group A, anastomosis of the proximal end left L7 ventral root (VR) distal S2 VR was performed, as well dorsal (DR) DR to reconstruct sensory motor function bladder. In B anastomosed, while kept intact Outcome measures included testing urodynamic measures. addition, we also monitored urinary infection...
Objective: Intradural nerve anastomosis for bladder innervation has been demonstrated to be useful. However, its clinical application remains limited because of the complex surgery, complications and extensive bony destruction. The purpose current study was demonstrate feasibility extradural spinal root in canines.Methods: Ten beagle dogs were used. length segment root, upper outlet (the point at which it emerges from dura mater) S2 (dS2), S3 (dS3) distance, diameters roots measured. numbers...
Aims To examine the protective effects of caffeine in rats with diabetes mellitus (DM) by using urodynamics. Methods Female Sprague‐Dawley ( n = 24) were divided into four groups: control group, DM + (5 mg/kg/day), and (10 mg/kg/day). was induced streptozotocin (STZ). Cystometric studies conducted on all rats. After 8 weeks treatment caffeine, urodynamic parameters, including bladder capacity, residual urine volume, voiding time, peak pressure, measured. Results had a higher capacity...
Management of non-neurogenic, non-obstructive dysuria represents one the most challenging dilemmas in urological practice. The main clinical symptom is increase residual urine. Voiding dysfunction cause or urinary retention, mainly due to decrease bladder contraction (the amplitude duration) outflow tract resistance. Sacral neuromodulation (SNM) has been used for > 10 years treat many kinds lower dysfunction. It become increasingly popular China recent years. Consequently, studies focusing...