A5101490121- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Pain Management and Treatment
- Cancer, Lipids, and Metabolism
- Urinary Tract Infections Management
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Connexins and lens biology
- Anorectal Disease Treatments and Outcomes
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal Regulation and Hypertension
- Prostate Cancer Treatment and Research
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Ureteral procedures and complications
- Spectroscopy and Chemometric Analyses
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Tobacco Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Beijing Hospital
2015-2023
Peking Union Medical College Hospital
2022
Peking University
2021
National Center for Geriatrics and Gerontology
2020
Tianjin Stomatological Hospital
2019
Abstract Interstitial cystitis/bladder pain syndrome (IC/BPS) has a significant impact on quality of life, but the etiopathogenesis remains largely unknown. The bladder microenvironment patients with IC/BPS to obtain biological evidence supporting diagnosis and novel therapy is systematically characterized. Single‐cell RNA sequencing (scRNA‐seq) image mass cytometry (IMC) are applied biopsies cohort. A total 42 distinct cell clusters identified from different groups. increased hyperactivated...
Purpose: To identify whether ferroptosis-related genes play predictive roles in bladder cancer patients and to develop a gene signature predict overall survival outcomes. Materials Methods: We downloaded the mRNA expression files clinical data of 256 samples (188 tumour 68 nontumour samples) from GEO database 430 (411 19 TCGA database. A multigene based on prognostic was constructed by least absolute shrinkage selection operator Cox regression analysis cohort. The cohort used validate...
A retrospective study was conducted on the clinical data of male patients who developed complications after artificial urethral sphincter (AUS) implantation at Beijing Hospital from March 2019 to December 2024. The evaluated occurrence, management, and outcomes these complications. Among 72 underwent AUS implantation, 10 (13.9%), aged 27-85 (64.9±19.4) years old, experienced following implantation. Two painless gross hematuria, which improved symptomatic treatment. involved control pump...
Donor kidney arteriosclerotic plaque is a risk factor for renal allograft functional injury. The aim of this study was to screen, identify, and verify differentially expressed genes (DEGs) proteins in plaques analyze their correlation with transplant function recovery. This included 82 deceased donor allogeneic recipients analyzed 20 eligible arterial specimens. Patients were divided into "no or mild" "moderate severe" groups. latter group further impaired normal Correlations between target...
The dysregulation of caspase 4 ( CASP4 ) expression is related to the occurrence, development, and outcome many malignant tumors; however, its role in clear cell renal carcinoma (ccRCC) remains unclear. Herein, we investigated tumor tissues relationship with clinical prognosis, immune infiltration, drug sensitivity status ccRCC patients. Oncomine Cancer Genome Atlas (TCGA) databases were used determine mRNA correlation between disease prognosis was evaluated using Kaplan–Meier analysis....
Lymph node metastasis (LNM) is an important prognostic factor for bladder cancer (BCA) and determines the treatment strategy. This study aimed to determine related clinicopathological factors of LNM analyze prognosis BCA. A total 10,653 eligible patients with BCA were randomly divided into training or verification sets using 2004–2015 data Surveillance, Epidemiology, End Results database. To identify overall survival BCA, we utilized Cox proportional hazard model. Independent risk evaluated...
We have previously reported that ferroptosis has an important role in bladder cancer development. In this study, we aimed to further explore the possible predictive ability of ferroptosis-related long non-coding RNAs (lncRNAs) and their relation with immune microenvironment immunotherapy response.The lncRNAs were identified by Pearson's correlation analysis. The lncRNA signature was developed univariate multivariate regression analyses. Only main effects independent variables analysis...
Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis unclear, and associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigenetics gained, providing new opportunities for detection treatment.We identified prognostic methylation sites based on DNA profiles BCA in TCGA database constructed specific subgroup.Based consistent clustering 402 CpGs, we seven subgroups that had significant association with survival. The...
Abstract Background Bladder cancer (BLCA) typically has a poor prognosis due to high relapse and metastasis rates. A growing body of evidence indicates that N6-methyladenosine (m6A) long non-coding RNAs (lncRNAs) play crucial roles in the progression BLCA treatment response patients with BLCA. Therefore, we conducted comprehensive RNA-seq analysis using data from The Cancer Genome Atlas (TCGA) establish an m6A-related lncRNA prognostic signature (m6A-RLPS) for Methods Consensus clustering...
Background: The regulatory role of ferroptosis in malignant tumours has been recently demonstrated. However, the potential roles mediation patterns bladder cancer remain elusive. Materials and Methods: 889 samples were comprehensively evaluated based on ferroptosis-related genes. underlying correlations between these multi-omic characteristics systematically analysed. individual quantified by ferropscore using principal component analysis algorithm. typical genes with prognostic further...
Objective: Sacral neuromodulation (SNM) has emerged as an effective therapy for refractory lower urinary tract dysfunction (LUTD). Remote programming holds promise in addressing the time and economic burdens associated with outpatient programming, especially patients observation period following Stage I implant surgery (where lead is implanted first without pulse generator). The study aimed to explore effectiveness patient satisfaction of remote SNM patients, analyze benefits gain from...
Background: Sacral neuromodulation (SNM) is an effective approach for treating lower urinary tract dysfunction (LUTD), and stimulation programming essential successful treatment. However, research on SNM various indications limited. Thus, we aimed to determine whether there were differences in the parameters different appropriate recommendations. Materials Methods: Clinical data retrospectively collected from patients with LUTD who underwent completed internal pulse generator (IPG)...
Abstract Background The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect age on node positivity (LN+). This study aimed evaluate LN+ MIBC. Methods We analyzed stage T2–T4 who had not received preoperative radiotherapy, at least one examined, and underwent cystectomy between 1998 2015. Cochran–Armitage trend test logistic univariate multivariate analyses...
Increasing evidence suggests the essential regulation of RNA N6-methyladenosine (m6A) modification in carcinogenesis and immune response. Nevertheless, potential impacts these modifications on tumor microenvironment (TME) cell infiltration characteristics clear-cell renal carcinoma (ccRCC) remain unclear. Utilizing a consensus clustering algorithm, we determined three m6A patterns identified m6A-related gene clusters among 569 ccRCC samples, which were associated with different biological...
Background: Bladder cancer (BLCA) is a common malignant tumour of the urinary system. Knowledge mechanism and treatment methods for BLCA remain limited.Methods: Robust rank aggregation was used to integrate five GEO bladder microarray datasets identifying differentially expressed genes (DEGs) between NMIBC MIBC. An immune-related gene (IRG)-based prognostic index (IRGPI) constructed using multivariate analysis. The reliability IRGPI evaluated independent datasets, correlations...
To evaluate the efficacy and safety of a novel remote programming sacral neuromodulation (SNM) system (BetterStim system) in treatment patients with refractory overactive bladder (OAB) for 3 years.A total 8 centers China enrolled 84 OAB. Following test stimulation 70 underwent implantation using BetterStim. All returned follow-up at 6 months postoperatively. After that, visits were conducted by telephone. Outcomes voiding diaries, symptom score (OABSS), questionnaires regarding OAB-related...