A5068385918- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Sexual Differentiation and Disorders
- Infectious Disease Case Reports and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Protease and Inhibitor Mechanisms
- Genetic factors in colorectal cancer
- Atherosclerosis and Cardiovascular Diseases
Huazhong University of Science and Technology
2024-2025
Union Hospital
2025
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2025
Sun Yat-sen University
2021-2024
Sun Yat-sen University Cancer Center
2021-2024
Union Hospital
2024
Beijing Hospital
2020-2023
Peking University
2023
State Key Laboratory of Oncology in South China
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Abstract While cancer-associated fibroblasts (CAFs) in the tumour microenvironment may play important roles bladder cancer (BCa) progression, their impacts on BCa chemoresistance remain unclear. Using human samples, we found that tissues possessed more CAFs than did adjacent normal tissues. Both presence of stroma and expression ERβ contribute to chemoresistance, cells interact affect expression. In vitro co-culture assays demonstrated compared with cells, had a higher capacity induce...
Abstract Androgen deprivation therapy (ADT) is a cornerstone treatment for locally advanced or metastatic prostate cancer (PCa). However, its potential effects on the tumor immune microenvironment (TIM) of PCa patients and underlying mechanism remain largely unclear. To explore ADT TIM, RNA sequencing was performed six paired pre-ADT biopsy post-ADT lesions, five paracancerous benign tissues from receiving neoadjuvant with PCa. Bioinformatics methods including ESTIMATE ssGSEA were used to...
Background Social media has revolutionized the way people communicate, and it been widely incorporated into medical practice. However, limited data are available regarding use of social by Chinese urologists in their Methods From 2014 to 2016, during China Urological Association's (CUA) Annual National Minimally Invasive Urology Academic Conference, an anonymous survey on usage was distributed participant urologists. Results The results survey, which completed 665 participants, indicate a...
The dysregulation of caspase 4 ( CASP4 ) expression is related to the occurrence, development, and outcome many malignant tumors; however, its role in clear cell renal carcinoma (ccRCC) remains unclear. Herein, we investigated tumor tissues relationship with clinical prognosis, immune infiltration, drug sensitivity status ccRCC patients. Oncomine Cancer Genome Atlas (TCGA) databases were used determine mRNA correlation between disease prognosis was evaluated using Kaplan–Meier analysis....
Background To date, prophylactic intravesical chemotherapy after radical nephroureterectomy is one of the few available treatments that effectively prevent secondary bladder cancer. However, treating all patients with excessive for who are at a low risk or insensitive to treatment. Thus, guide individualized clinical treatment, in addition identifying cancer recurrence, it equally necessary identify will benefit most from prophylactic, postoperative instillation therapy. Methods Epidermal...
Abstract Background Identifying cellular and functional heterogeneity within aged prostate is critical for understanding the spatial distribution of diseases. Methods Aged human peripheral zone (PZ) transitional (TZ) tissues were used single‐cell RNA‐sequencing. Results validated by immunofluorescence staining. We found that club/hillock epithelial cells, compared with other had significantly higher NOTCH signaling activity expressed levels neuro‐stems but lower androgen‐related genes. These...
The next-generation androgen receptor (AR) inhibitor enzalutamide is the mainstay treatment for metastatic prostate cancer. Unfortunately, resistance occurs rapidly in most patients, and once occurs, options are limited. Therefore, there an urgent need to identify effective targets overcome resistance. Here, using a genome-wide CRISPR-Cas9 library screen, we found that targeting glycolytic enzyme, phosphoglycerate mutase PGAM2, significantly enhanced sensitivity of enzalutamide-resistant...
Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis unclear, and associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigenetics gained, providing new opportunities for detection treatment.We identified prognostic methylation sites based on DNA profiles BCA in TCGA database constructed specific subgroup.Based consistent clustering 402 CpGs, we seven subgroups that had significant association with survival. The...
Our understanding of the molecular pathogenesis LAMA2 -related muscular dystrophy ( -MD) requires improving. Here, we report phenotype, neuropathology and transcriptomics data (scRNA-seq bulk RNA-seq) a new Lama2 knockout mouse (dy H /dy ) which was created based on human -MD mutation hotspot region using CRISPR-Cas9. The dy mice presented severe phenotype with dystrophy. Mouse brain scRNA-seq showed that gene expressed predominantly specifically in vascular leptomeningeal fibroblasts smooth...
To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, TCGA our PCa tissue microarray cohort were included study. Weighted gene co-expression network analysis (WGCNA) non-negative matrix factorization used to cluster patients screen genes that play a vital (hub gene). Immunohistochemistry staining was protein level UBE2C prostatic tissues. Through WGCNA, we found module (named purple module) is strongly associated with Gleason...
Vascular remodelling is an essential pathophysiological state in many circulatory diseases. Abnormal vascular smooth muscle cell (VSMC) behaviour leads to neointimal formation and may eventually results major adverse cardiovascular events. The C1q/TNF-related protein (C1QTNF) family closely associated with disease. Notably, C1QTNF4 has unique two C1q domains. However, the role of diseases remains unclear.C1QTNF4 expression was detected human serum artery tissues using ELISA multiplex...
To determine whether SRD5A2 promoter methylation is associated with cancer progression during androgen deprivation therapy (ADT) in CRPC.
Objective: Obesity resulting from high-fat diets has a close relationship with the morbidity and mortality associated Prostate cancer (PCa) in males. The anti-cancer role of Icaritin (ICT, traditional Chinese herbal medicine) been reported several types including PCa. Adipokines are novel adipocyte-specific secretory protein, which plays key development various diseases obesity, diabetes, atherosclerosis, cancer. However, function ICT molecular mechanisms underlying its PCa regression...
Background: Bladder cancer (BLCA) is a common malignant tumour of the urinary system. Knowledge mechanism and treatment methods for BLCA remain limited.Methods: Robust rank aggregation was used to integrate five GEO bladder microarray datasets identifying differentially expressed genes (DEGs) between NMIBC MIBC. An immune-related gene (IRG)-based prognostic index (IRGPI) constructed using multivariate analysis. The reliability IRGPI evaluated independent datasets, correlations...
To evaluate the efficacies of different chemotherapy regimens in risk sub-groups for prevention bladder recurrence after radical nephroureterectomy (RNU).Between 2004 and 2012, we recruited 685 patients who underwent RNU upper tract urothelial carcinoma at 4 Chinese institutions. We assessed whether type intravesical regimen affected rate with levels RNU.For all patients, was lower than without, but no significant differences were found between 2 (single dose or relatively long-term...
Abstract To evaluate whether the addition of biomarkers to traditional clinicopathological parameters may help increase accurate prediction prostate re‐biopsy outcome. A training cohort with 98 patients and a validation 72 were retrospectively recruited into our study. Immunohistochemical analysis was used immunoreactivity group in initial negative biopsy normal‐looking tissues cohorts. p‐STAT3, Mcm2, and/or MSR1 selected out 10 construct biomarker index for predicting cancer high‐grade...
The current standard surgical treatment for non-metastatic upper urinary tract urothelial carcinoma (UTUC) is radical nephroureterectomy (RNU) with bladder cuff excision (BCE). Typically, BCE techniques are classified in one of the following three categories: An open technique described as intrasvesical incision cuff, a transurethral (TUBC), and an extravesical (EVBC) method. Even though each these management widely used, there no consensus about which intervention superior, best oncologic...
Our understanding of the molecular pathogenesis LAMA2-related muscular dystrophy (LAMA2-MD) requires improving. Here, we report phenotype, neuropathology and transcriptomics data (scRNA-seq bulk RNA-seq) a new Lama2 knockout mouse (dyH/dyH) which was created based on human LAMA2-MD mutation hotspot region using CRISPR-Cas9. The dyH/dyH mice presented severe phenotype with dystrophy. Mouse brain scRNA-seq showed that gene expressed predominantly specifically in vascular leptomeningeal...
Understanding the underlying pathogenesis of LAMA2 -related muscular dystrophy ( -MD) have been hampered by lack genuine mouse model. We created a new Lama2 knockout (dy H /dy ) and reported here its close simulation to human neuropathology symptoms. first established that was predominantly expressed within cortical surface normal brain, specifically, highly concentrated in vascular leptomeningeal fibroblasts smooth muscle cells with modest presence astrocytes. Our mice confirmed specific...