A5100447603- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Circular RNAs in diseases
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Pelvic floor disorders treatments
- Hormonal and reproductive studies
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- RNA Research and Splicing
- Gynecological conditions and treatments
- Urological Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Genital Health and Disease
- Ureteral procedures and complications
- Ferroptosis and cancer prognosis
Third Xiangya Hospital
2020-2025
Central South University
2016-2025
Xiangya Hospital Central South University
2014-2024
Capital Medical University
2023-2024
Beijing Institute of Neurosurgery
2024
Fourth Hospital of Hebei Medical University
2013-2024
Hebei Medical University
2013-2024
Chenzhou First People's Hospital
2024
Dali University
2024
The First People's Hospital of Changzhou
2023-2024
In Western countries and China, the dietary habit of high calories usually results in hyperlipidemia, which is closely associated with cardiovascular diseases. study, we investigated antihyperlipidemic effect oryzanol its molecular mechanism fat diet (HFD) mouse model. total, 60 ICR mice were randomly divided into control group, HFD HFD+Ory group. The from group additionally fed 100 mg/kg by intragastric administration. Our data indicated that treatment for 10 weeks significantly reduced...
Aberrant expressions of long non-coding RNAs (lncRNAs) are the culprits carcinogenesis via regulating tumor suppressor or oncogene. LncRNA nuclear enriched abundant transcript 1 (NEAT1) has been identified to be an oncogene promote growth and metastasis many cancers. However, clinical significance function NEAT1 in osteosarcoma (OS) remain discovered. We here collected OS tissues (n=40) adjacent non-tumor (n=20) determine expression its significance. was overexpressed tissues, which...
The present study sought to identify a panel of DNA markers for noninvasive diagnosis using cell-free (cfDNA) from urine supernatant or cellular sediments hematuria patients. A 48 bladder cancer-specific genes was selected. next-generation sequencing-based assay with cfDNA barcode-enabled single-molecule test employed. Mutation profiles blood, urine, and tumor sample 16 cancer patients were compared. Next, urinary prospectively collected 125 (92 cases 33 controls) analyzed the 48-gene panel....
To assess 68Ga-PSMA PET/CT for detection of low- and intermediate-risk prostate cancer (PCa), high-risk PCa in comparison with mpMRI, respectively, to determine which are more likely be detected by PET/CT.We conducted a retrospective analysis patients who had undergone biopsy and/or radical prostatectomy were scanned mpMRI between June 2019 March 2021. The images scored the Prostate Imaging-Reporting Data System Version 2.1 (PI-RADS) classified as either negative (PI-RADS 1-3) or positive...
Abstract Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) cerebrospinal fluid (CSF) these Prospectively enrolling 45 patients with lesions, including diffuse midline glioma (DMG), H3K27-altered (14/45), glioblastoma (1/45), H3-wildtype-astrocytoma (10/45), ependymoma (11/45), and other lesions (9/45), CSF samples were collected via lumbar puncture...
Ionizing radiation (IR) is one of the major clinical therapies cancer, although it increases epithelial-mesenchymal transition (EMT) non-small cell lung cancer (NSCLC), unexpectedly. The cellular and molecular mechanisms underlying this role are not completely understood.We used NSCLC lines as well tumor specimens from 78 patients with to evaluate p53, Cathepsin L (CTSL) EMT phenotypic changes. Xenograft models was also utilized examine roles mutant p53 (mut-p53) CTSL in regulating...
Abstract Objective Paragangliomas of the urinary bladder (UBPGLs) are rare neuroendocrine tumours and pose a diagnostic surgical challenge. It remains unclear what factors contribute to timely presurgical diagnosis. The purpose this study is identify contributing missing diagnosis UBPGLs before surgery. Design, Patients Measurements A total 73 patients from 11 centres in China, 51 6 Europe 1 center United States were included. Clinical, genetic data collected compared diagnosed versus after...
Abstract Benign prostatic hyperplasia (BPH) is a multifactorial disease in which abnormal growth factor activation and embryonic reawakening are considered important factors. Here we demonstrated that the aberrant of transforming β (TGF-β)/Rho kinase 1 (ROCK1) increased stemness BPH tissue by recruiting mesenchymal stem cells (MSCs), indicating role BPH. When TGF-β/ROCK1 abnormally activated, MSCs recruited differentiate into fibroblasts/myofibroblasts, leading to prostate stromal...
In biological processes, the balance between positive and negative inputs is critical for an effective physiological response to prevent disease. A case in point germinal center (GC) reaction, wherein high mutational proliferation rates are accompanied by obligatory suppression of DNA repair machinery. Understandably, when GC reaction goes awry, loss immune cells or lymphoid cancer ensues. Here, we detail functional interactions that make microRNA 155 (miR-155) a key part this process. Upon...
The prolonged and frequent use of laparoscopic equipment raises ergonomic risks that may cause physical distress for surgeons. We aimed to assess the prevalence urologic surgeons' associated with problems in operating room (OR) their awareness guidelines China.A sample 300 urologists China was assessed using a questionnaire on demographic information, issues OR, musculoskeletal symptoms, OR.There were 241 survey respondents (86.7%) valid questionnaires. Among respondents, only 43.6% placed...
Apoptosis of bone marrow-derived mesenchymal stem cells (BMMSCs) is an essential pathogenic factor osteoporosis. Ginsenoside-Rb2 (Rb2), a 20(S)-protopanaxadiol glycoside extracted from ginseng, potent treatment for loss, which raises interest regarding the metabolism area. In present study, we found that dose-response Rb2 inhibited high dosage dexamethasone (Dex)-induced apoptosis in primary murine BMMSCs. Interestingly, promoted GPR120 induction, unsaturated long-chain fatty acid receptor....
Compelling evidence suggests that benign prostatic hyperplasia (BPH) development involves accumulation of mesenchymal-like cells derived from the epithelium by epithelial-mesenchymal transition (EMT). Transforming growth factor (TGF)-β induces EMT phenotypes with low E-cadherin and high vimentin expression in epithelial cells. Here we report LPS/TLR4 signalling down-regulation bone morphogenic protein activin membrane-bound inhibitor (BAMBI), which enhances TGF-β process during hyperplasia....
Objective: Gastric cancer is the most common malignant tumor of digestive system. The progression from gastritis to gastric may be related genetic factors, but specific molecular mechanism remains unclear. Therefore, an in-depth study and significant. Methods: We downloaded two gene profiles, GSE2669 GSE116312, Gene Expression Omnibus (GEO) database. This aims apply bioinformatics technology mine differentially expressed genes (DEGs), DEGs annotation, protein-protein interaction (PPI)...
Abstract Background Bladder cancer (BC) is among the most common cancers diagnosed in men USA. The current gold standards for diagnosis of BC are invasive or lack sensitivity to correctly identify disease. Methods An aptamer-based screen analyzed expression 1317 proteins compared urology clinic controls. top hits were subjected systems biology analyses. Next, 30 urine ELISA-validated an independent cohort 68 subjects. Three these next validated differing ethnicity. Results Systems analysis...
Benign prostatic hyperplasia (BPH) is a prevalent disease among middle-aged and elderly males, but its pathogenesis remains unclear. Dysbiosis of the microbiome increasingly recognized as significant factor in various human diseases. Prostate tissue also contains unique microbiome, dysbiosis has been proposed to contribute prostate Here, we obtained tissues preoperative catheterized urine from 24 BPH individuals, 8 normal samples controls, which followed strict aseptic measures. Using...
AIM:To study the differential gene expression profiles of target cells in primary gastric cancer and its metastatic lymph nodes using laser microdissection (LMD) combination with cDNA microarray. METHODS:Normal tissue samples from 30 healthy individuals, 36 carcinoma node metastasis 58 patients during resection were obtained LMD microarray independently.After P27-based amplification, aRNA (group 1) specimens remaining 22 2) applied to microarray.Semiquantitative reverse transcriptase...