A5101888938- Muscle Physiology and Disorders
- DNA Repair Mechanisms
- Cardiomyopathy and Myosin Studies
- Cell Adhesion Molecules Research
- Biological and pharmacological studies of plants
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Advanced Authentication Protocols Security
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Hydraulic and Pneumatic Systems
- Metabolism and Genetic Disorders
- Photosynthetic Processes and Mechanisms
- Advanced Image Processing Techniques
- Plant Stress Responses and Tolerance
- Blood properties and coagulation
- Autophagy in Disease and Therapy
- Genomic variations and chromosomal abnormalities
- Neurological Disease Mechanisms and Treatments
Chengdu Medical College
2025
Henan Agricultural University
2025
Women's Hospital, School of Medicine, Zhejiang University
2016-2024
Nanjing Agricultural University
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Chongqing Medical University
2021-2024
Second Affiliated Hospital of Chongqing Medical University
2021-2024
Peking University First Hospital
2021-2024
Peking University
2021-2024
Dalian Medical University
2021-2024
Background Microglial activation plays an important role in neurodegenerative diseases by producing several proinflammatory enzymes and cytokines. The phenolic glucoside gastrodin, a main constituent of Chinese herbal medicine, has been known to display anti-inflammatory properties. current study investigates the potential mechanisms whereby gastrodin affects expression potentially pro-inflammatory proteins cultured murine microglial BV-2 cells stimulated with lipopolysaccharide (LPS)....
Abstract Plants respond to phosphate (Pi) starvation by exhibiting a suite of developmental, biochemical, and physiological changes cope with this nutritional stress. To understand the molecular mechanism underlying these responses, we isolated an Arabidopsis (Arabidopsis thaliana) mutant, hypersensitive starvation1 (hps1), which has enhanced sensitivity in almost all aspects plant responses Pi starvation. Molecular genetic analyses indicated that mutant phenotype is caused overexpression...
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome (ALP) are the two major protein degradation pathways, which critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) a master regulator of ALP. However, characteristics TFEB its role in not fully investigated. Here we reported half-life around 13.5 h neuronal-like cells, degraded through both non-neuronal cells. Moreover, impairment...
Abstract Background More than 50 loci are associated with spinocerebellar ataxia (SCA), and the most frequent subtypes share nucleotide repeats expansion, especially CAG expansion. Objective The objective of this study was to confirm a novel SCA subtype caused by Methods We performed long‐read whole‐genome sequencing combined linkage analysis in five‐generation Chinese family, finding validated another pedigree. three‐dimensional structure function THAP11 mutant protein were predicted....
Significance Endoplasmic reticulum (ER)-associated degradation (ERAD) is a well-studied cellular process in yeast and mammalian systems. Recent molecular genetic studies the reference plant Arabidopsis have revealed that ERAD also conserved plants. Here we report an for degrading misfolded/mutant receptor-like kinases requires plant-specific protein, ethyl methanesulfonate-mutagenized brassinosteroid-insensitive 1 suppressor 7 (EBS7), localized to ER membrane induced by stress. Our...
Existing recommender systems mostly focus on recommending individual items which users may be interested in. User-generated item lists the other hand have become a popular feature in many applications. E.g., Goodreads provides with an interface for creating and sharing interesting book lists. These user-generated complement main functionality of corresponding application, intuitively alternative way to browse discover consumed. Unfortunately, existing are not designed In this work, we study...
Abstract HORMAD1 is a meiosis-specific protein that promotes synapsis and recombination of homologous chromosomes in meiotic prophase. Originally identified as cancer/testis antigen, also aberrantly expressed several cancers. However, the functions cancer cells are still not clear. Here, we show wide variety cancers compromises DNA mismatch repair cells. Mechanistically, interacts with MCM8–MCM9 complex prevents its efficient nuclear localization. As consequence, HORMAD1-expressing have...
Abstract Background Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease (AD) and characterized by a complex etiology, high morbidity, rate of blindness. AU remission has been observed in pregnant female patients. However, effects progesterone (PRG), critical hormone for reproduction, on treatment regulatory mechanisms remain unclear. Methods To this end, we established experimental (EAU) animal models constructed high-dimensional immune atlas EAU-model mice undergoing...
In the meiotic prophase, programmed DNA double-strand breaks are repaired by recombination. Recombination-defective meiocytes eliminated to preserve genome integrity in gametes. BRCA1 is a critical protein somatic homologous recombination, but studies have suggested that dispensable for Here we show essential Interestingly, also has function eliminating recombination-defective oocytes. Brca1 knockout (KO) rescues survival of Dmc1 KO oocytes far more efficiently than removing CHK2, vital...
Respecting the significant role of inflammation in acute ischemic stroke (AIS) development, we explored correlations inflammatory cytokines and lipoprotein-associated phospholipase-A2 (Lp-PLA2) with AIS their early prognostic value. The retrospectively enrolled subjects [Study (AIS patients) Control (healthy volunteers) groups] were determined for serum index levels. Neurological impairment prognosis patients assessed. relationship National Institutes Health Stroke Scale (NIHSS) indexes risk...
To control pandemics, a universal adjuvant platform that can deliver antigens and stimulate the immune system rapidly elicits humoral cellular responses is needed, especially one body's to produce protective immunological memory. However, design, composition, mechanism of adjuvants have presented considerable challenges. The types currently approved in clinics are rare far from meeting requirements vaccine development. In this study, we prepared yeast-derived manganese zinc metal-organic...
Abstract BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). deficient mice are embryonic lethal. Previous studies have shown that 53BP1 knockout (KO) rescues lethality of hypomorphic mutant restoring HR. Here, we show KO can partially rescue total mice, but HR not restored in BRCA1-53BP1 double (DKO) mice. As a result, DKO cells extremely sensitive to PARP inhibitors (PARPi). In addition deficiency, elevated microhomology-mediated end joining (MMEJ)...
Due to the absorption and scattering effects of light in water bodies non-uniformity insufficiency artificial illumination, underwater images often present various degradation problems, impacting their utility applications. In this paper, we propose a model-based image simulation learning-based enhancement method for coping with problems images. We first derive simplified model describing images, then that can generate wide range parameter values. The proposed also comes an image-selection...
Abstract Background Lotus ( Nelumbo nucifera G.) is an important aquatic plant with high ornamental, economic, cultural and ecological values, but abiotic stresses seriously affect its growth distribution. Q-type C2H2 zinc finger proteins (ZFPs) play role in development environmental stress responses. Although the gene family has been identified some plants, limited reports carried out it lotus. Results In this study, we 45 NnZFP members Based on phylogenetic tree, these were divided into 4...
In the shallow-water environment, underwater images often present problems like color deviation and low contrast due to light absorption scattering in water body, but for deep-sea images, additional uneven brightness regional shift can also exist, use of chromatic inhomogeneous artificial lighting devices. Since latter situation is rarely studied field image enhancement, we propose a new model include it analysis degradation. Based on theoretical study model, comprehensive method enhancing...
The most refractory symptom of herpes zoster (HZ) is pain. Approximately 90% people who have HZ suffer from Early use antiviral medications has been found to reduce pain across all stages the disease. Although many agents via oral or intravenous administration were recommended by clinical practice, best approach prevent HZ-associated remains uncertain.The purpose this study was compare efficacy and adverse events various used for treatment through a network meta-analysis.A systematic review...