A5079879342- Computational Drug Discovery Methods
- Systemic Lupus Erythematosus Research
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Pharmacogenetics and Drug Metabolism
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Metabolomics and Mass Spectrometry Studies
- Cutaneous Melanoma Detection and Management
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Vascular Malformations Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Digestive system and related health
- Cancer Cells and Metastasis
- Vascular Malformations and Hemangiomas
- Retinal Diseases and Treatments
- Dermatological and COVID-19 studies
- Pregnancy and preeclampsia studies
- Advanced biosensing and bioanalysis techniques
- Pregnancy and Medication Impact
- Ophthalmology and Eye Disorders
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- interferon and immune responses
Central South University
2019-2025
Xiangya Hospital Central South University
2019-2025
Ganzhou People's Hospital
2024
Sun Yat-sen University
2008-2024
Hunan Cancer Hospital
2022
Eye Center
2022
Hunan University
2022
Zhejiang Hospital
2010
Zhejiang Provincial Hospital of TCM
2010
The arginine/glycine-rich region termed the RGG domain is usually found in G-quadruplex (G4)-binding proteins and important G4–protein interactions. Studies on binding mechanism of domains that small segments (RGG motif) inside contribute greatly to G4 affinity. However, unlike entire have been broadly explored, role motif remains obscure, with very limited study. Herein, clarify interactions, we systematically investigated affinity mode between RGG-motif peptides G4s. internal arrangement...
Abstract Background Sleep loss (SL) is a health issue associated with the higher risk of autoimmune and inflammatory disorders. However, connection between SL, immune system, diseases remains unknown. Methods We conducted mass cytometry, single‐cell RNA sequencing, flow cytometry to analyze how SL influences system disease development. Peripheral blood mononuclear cells from six healthy subjects before after were collected analyzed by experiments subsequent bioinformatic analysis identify...
Drug-drug interaction (DDI) often causes serious adverse reactions and thus results in inestimable economic social loss. Currently, comprehensive DDI evaluation has become a major challenge pharmaceutical research due to the time-consuming costly process of experimental assessment it is high necessity develop effective silico methods predict evaluate DDIs accurately efficiently. In this study, based on large number substrates inhibitors related five important CYP450 isozymes (CYP1A2, CYP2C9,...
Background Skin and subcutaneous disease is the fourth-leading cause of nonfatal burden worldwide constitutes one most common burdens in primary care. However, there a severe lack dermatologists, particularly rural Chinese areas. Furthermore, although artificial intelligence (AI) tools can assist diagnosing skin disorders from images, database for population limited. Objective This study aims to establish AI based on presents an initial six diseases. Methods Each image was captured with...
Abstract Background Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease (AD) and characterized by a complex etiology, high morbidity, rate of blindness. AU remission has been observed in pregnant female patients. However, effects progesterone (PRG), critical hormone for reproduction, on treatment regulatory mechanisms remain unclear. Methods To this end, we established experimental (EAU) animal models constructed high-dimensional immune atlas EAU-model mice undergoing...
The most common intraocular malignancy in adults remains uveal melanoma (UVM), and those with metastatic disease have a poor outlook. Proliferation, angiogenesis, metastasis of tumor cells can be triggered by cuproptosis, affecting the survival cancer patients. Nonetheless, cuproptosis-related genes (CRGs) not been identified UVM. In this study, we analyzed 10 CRGs 80 patients UVM Cancer Genome Atlas (TCGA) database regarding alterations including copy number variation methylation. We...
Purpose: To report on the safety and efficacy of 256-channel Intelligent Micro Implant Eye epiretinal prosthesis system (IMIE 256). Methods: The IMIE 256 implants were implanted in right eyes five subjects with end-stage retinitis pigmentosa. Following implantation, underwent visual rehabilitation training for 90 days, their performance was evaluated using grating acuity test, Tumbling E direction motion, square localization, orientation mobility test. evaluate 256, all adverse events...
Dendritic cells (DCs) are critical for pathogen recognition and Ag processing/presentation. Human monocyte-derived DCs (moDCs) have been extensively used in experimental studies DC-based immunotherapy approaches. However, the extent of human moDC peripheral heterogeneity their interrelationship remain elusive. In this study, we performed single-cell RNA sequencing moDCs blood DCs. We identified seven subtypes within moDCs: five corresponded to type 2 conventional (cDC2s), other two were...
Extensive immune adaptations occur during pregnancy to ensure successful delivery. However, these changes can increase the risk of disease in mother. Here, we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages elucidate dynamic transcriptional maternal system. Gradual reduced cytotoxicity phenotype highly variable cytotoxic T and natural killer cell types were observed pregnancy. Reduced T- B-cell response-related MHC-II CD40...
Glioma is the most common tumour of central nervous system, with a poor prognosis and an increasing trend incidence in recent years; it also beginning to affect younger age groups more. Added this, cuproptosis new form cell death. Indeed, when certain amount copper accumulates cell, affects specific mitochondrial metabolic enzymes that leads death-a phenomenon known as cuproptosis. In this study, we applied bioinformatics analysis, and, according results study analysis Gene Ontology (GO),...
Glucocorticoids (GCs) are widely used immunosuppressive drugs for autoimmune diseases, although considerable gaps exist between current knowledge of the mechanisms GCs and their conclusive immune-regulatory effects. Here we generated a single-cell transcriptional immune cell atlas based on prednisone-treated or untreated experimental uveitis (EAU) mice. Immune cells were globally activated in EAU, prednisone partially reversed this effect terms composition, gene expression, transcription...
The purpose of this study was to elucidate the effects interleukin (IL)-38 on experimental autoimmune uveitis (EAU) and its underlying mechanisms.Mice with EAU were treated IL-38, retinas cervical draining lymph nodes (CDLNs) analyzed by flow cytometry. Single-cell RNA sequencing (scRNA-seq) conducted analyze immune cell profiles CDLNs from normal, EAU, IL-38-treated mice.Administration IL-38 attenuated symptoms reduced proportion T helper 17 (Th17) 1 (Th1) cells in CDLNs. In scRNA-seq...
Tacrolimus (TAC) is a first-line immunosuppressant for patients with refractory nephrotic syndrome (NS). However, there high inter-patient variability of TAC pharmacokinetics, thus therapeutic drug monitoring (TDM) required. In this study, we aimed to employ machine learning algorithms investigate the impact clinical and genetic variables on dose/weight-adjusted trough concentration (C0/D) in Chinese children NS, then develop validate C0/D prediction models.The association 82 244 single...
Background Neural apoptosis is generally believed to be mediated by two distinct pathways, caspase-dependant and caspase-independent pathways. This study investigated the apoptotic pathways involved in retinal ganglion cells acute diabetes rats. Methods Diabetes was induced male Wistar rats a peritoneal injection of streptozotocin (STZ). Expression localization caspase-3 apoptosis-inducing factor (AIF) proteins retina diabetic examined Western blotting immunohistochemistry analyses. Terminal...
Abstract To investigate the surgical outcomes of pars plana vitrectomy (PPV) combined with inverted multi-layer internal limiting membrane (ILM) flap for treatment macular hole retinal detachment in high myopia. We retrospectively analysed medical records (MHRD) patients The were divided into two groups different procedure: ILM group (group 1, 27 eyes) and peeling 2, 29 eyes). Retinal reattachment rate, closure rate at last follow-up BCVA 6 months post-operation compared between groups....
Intestinal fibrosis is a significant clinical challenge in inflammatory bowel diseases, but no effective anti-fibrotic therapy currently available. Glucagon receptor (GCGR) and glucagon-like peptide 1 (GLP1R) are both hormone receptors involved energy metabolism of epithelial cells. However, their role intestinal the underlying mechanisms remain largely unexplored. Herein GCGR GLP1R were found to be reduced stenotic ileum patients with Crohn's disease as well fibrotic colon mice chronic...
Subconjunctival orbital fat prolapse has been rarely described in the literature, often leading to misdiagnosis. In this article, we present clinical features and treatment of patients with subconjunctival as experienced our clinic.Cases were evaluated retrospectively from records Zhongshan Ophthalmic Center at Sun Yat-sen University for period January 1, 1991 December 31, 2010.A total 46 (33 males 13 females) identified. Their ages ranged 44.0 82.0 years (mean age, 65.8 y). The right eye...