A5100338370- Prostate Cancer Treatment and Research
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related cognitive impairment studies
- Hippo pathway signaling and YAP/TAZ
- Estrogen and related hormone effects
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- Chemokine receptors and signaling
- Cyclone Separators and Fluid Dynamics
- Fluid Dynamics and Mixing
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Respiratory Support and Mechanisms
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Tryptophan and brain disorders
- Cancer Mechanisms and Therapy
- Mycotoxins in Agriculture and Food
- Cancer-related gene regulation
Centre for Interdisciplinary Research in Rehabilitation
2024-2025
Sun Yat-sen University
2018-2025
Nanjing University of Information Science and Technology
2025
Huazhong University of Science and Technology
2024
Central Hospital of Wuhan
2024
Washington State University Spokane
2018-2024
Central South University
2017-2024
Shanghai Jiao Tong University
2015-2024
Zhejiang Cancer Hospital
2017-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Advances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated functional interpretation of disease-associated variants discovered from genome-wide association studies (GWASs). However, identification trait-relevant cell populations is often impeded by inherent technical noise and high sparsity scRNA-seq data. Here, we developed scPagwas, a computational approach that uncovers cellular context integrating pathway activation transformation data GWAS summary statistics....
Abstract Background The advent of genomics-based technologies has revolutionized many fields biological enquiry. However, chromosome walking or flanking sequence cloning is still a necessary and important procedure to determining gene structure. Such methods are used identify T-DNA insertion sites so especially relevant for organisms where large libraries have been created, such as rice Arabidopsis . currently available cloning, including the popular TAIL-PCR technique, relatively laborious...
Melatonin is a naturally occurring compound in plants. Here, we tested the effect of exogenous melatonin on rapeseed (Brassica napus L.) grown under salt stress. Application 30 µmol L−1 alleviated salt-induced growth inhibition, and shoot fresh weight, dry root weight seedlings treated with increased by 128.2, 142.9, 122.2, 124.2%, respectively, compared to those In addition, several physiological parameters were evaluated. The activities antioxidant enzymes including peroxidase (POD),...
In many cancers, the tumor microenvironment (TME) is largely immune suppressive, blocking antitumor immunity and resulting in immunotherapy resistance. Interleukin 10 (IL-10) a major player controlling immunosuppressive TME different murine models. Increased IL-10 production suppresses intratumoral dendritic cell of interleukin 12, thereby limiting cytotoxic T-cell responses activation NK cells during therapy. We engineered, formulated, delivered genes encoding an protein trap to change TME,...
Rationale: Mitochondrial dysfunction facilitates heart failure development forming a therapeutic target, but the mechanism involved remains unclear. We studied whether Hippo signaling pathway mediates mitochondrial abnormalities that results in onset of dilated cardiomyopathy (DCM). Methods: Mice with DCM due to overexpression kinase Mst1 were studied. phenotype was evident adult animals contractile identified as an early sign at 3 weeks postnatal. Electron microscopy, multi-omics and...
Adolescence is a critical phase of development and frequently period initiating engaging in risky behaviors, including alcohol other substance use. The COVID-19 pandemic associated stressors might have affected adolescent involvement these behaviors. To examine use patterns understand how among high school students changed before during the pandemic, CDC analyzed data from nationally representative Youth Risk Behavior Survey. This report presents estimated prevalences current (i.e., previous...
Background Epithelial damage, repair and remodelling are critical features of chronic airway diseases including obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged epithelia causes inflammation via its receptor, serum stimulation-2 (ST2). Oxidation IL-33 to a non-ST2-binding form (IL-33 ox ) is thought limit activity. We investigated whether has functional activities that independent ST2 in the epithelium. Methods In vitro epithelial damage assays...
Abstract Background More than 50 loci are associated with spinocerebellar ataxia (SCA), and the most frequent subtypes share nucleotide repeats expansion, especially CAG expansion. Objective The objective of this study was to confirm a novel SCA subtype caused by Methods We performed long‐read whole‐genome sequencing combined linkage analysis in five‐generation Chinese family, finding validated another pedigree. three‐dimensional structure function THAP11 mutant protein were predicted....
Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), mitochondrial enzyme that degrades biogenic dietary monoamines, human PC stroma, which was associated with poor clinical outcomes patients. Knockdown or overexpression MAOB prostate fibroblasts indicated promotes cocultured cell proliferation, migration, invasion co-inoculated mice. Mechanistically,...
Abstract Eph receptors, the largest subfamily of transmembrane tyrosine kinase have been increasingly implicated in various physiologic and pathologic processes, roles family members during tumorigenesis recently attracted growing attention. Until now, research on EphB3 function cancer is limited to focusing tumor suppression by EphB receptors colorectal cancer. However, its other types remains poorly investigated. In this study, we explored non–small-cell lung (NSCLC). We found that...
Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 binding specificity using peptide phage display in a metazoan, worm Caenorhabditis elegans , discovered it structurally mirrors budding yeast Saccharomyces cerevisiae . then mapped interactome stringent two‐hybrid compared with equivalent map for yeast. found resembles analogous network because is significantly enriched...
Due to the increasing demand for producing chickens with high meat quality, there is a need determine its mode of action on chicken quality traits across wider age spectrum. In this study, five groups 200 male Da-Heng type birds were reared until slaughter 60, 90, 120, 150, 180 days old and breast muscle performance, traits, myofiber characteristics evaluated. The larger body weight are based diameter area, less density older than younger birds. There was an effect all (p < 0.05). Older...
Neuroendocrine prostate cancer (NEPC) is a lethal subtype arising as consequence of more potent androgen receptor (AR) targeting in castration-resistant (CRPC). Its molecular pathogenesis remains elusive. Here, we report that the Wnt secretion mediator Wntless (WLS) major driver NEPC and aggressive tumor growth vitro vivo. Mechanistic studies showed WLS transcriptional target suppressed by AR activates ROR2/PKCδ/ERK signaling pathway to support neuroendocrine (NE) traits proliferative...
The zinc finger antiviral protein (ZAP) is an interferon-stimulated gene that restricts the replication of retroviruses, alphaviruses, and filoviruses. Relatively little known, however, regarding detailed mechanism ZAP induction during viral infections. We show that, although being inducible by either interferon or virus, expression more efficiently activated virus than are several other classical genes occurs under direct control regulatory factor 3 (IRF3) independent paracrine/autocrine...
The gas–liquid separator is a key component in the gas removal system thorium molten salt reactor (TMSR). In this paper, an experimental study focusing on core formation was carried out. We observed that of air depends primarily back pressure separator. Gas visualized for range pressures, swirl numbers, and Reynolds numbers. Analysis flow patterns indicated may be defined as four stages: “air with suction,” “tadpole-shaped core,” “cloudy “rod core.” When rod achieved, bubbles will separated...