A5055027808- Animal Nutrition and Physiology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Muscle Physiology and Disorders
- Genetic and phenotypic traits in livestock
- Livestock and Poultry Management
- RNA modifications and cancer
- RNA Research and Splicing
- interferon and immune responses
- Meat and Animal Product Quality
- Peroxisome Proliferator-Activated Receptors
- Reproductive Biology and Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Antioxidant Activity and Oxidative Stress
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- TGF-β signaling in diseases
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Cardiomyopathy and Myosin Studies
- Biochemical Analysis and Sensing Techniques
- Autophagy in Disease and Therapy
Sichuan Agricultural University
2015-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Virginia Tech
2014-2018
Southwest University
2018
Abstract Folliculogenesis is a complex biological process involving central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture an important transcription regulator; however, little known about dynamics role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic over ten follicular stages assess how it influences gene expression at three key stages: prehierarchical small white follicles, first largest...
An optical monitoring device combining a smartphone with polychromatic ratiometric fluorescence-colorimetric paper sensor was developed to detect Hg2+ and S2– in water seafood. This included the detection of food deterioration made possible by processing sensing data machine learning algorithm. The fluorescence composed blue fluorescent carbon quantum dots (CDs) (BU-CDs) green red CdZnTe (QDs) (named GN-QDs RD-QDs, respectively). experimental results density functional theory (DFT) prove...
Scope: Myogenesis involves a series of complex cellular and developmental processes regulated by many genes, transcription factors non-coding RNAs. Recent studies have demonstrated the involvement circular RNAs (circRNAs) in myogenesis. While previous established role for some circRNAs, precise functions mechanisms circRNAs skeletal muscle development are still not completely understood chicken. Methods: To identify potential during chicken embryonic development, rRNA- libraries sequencing...
Broodiness in laying hens results atrophy of the ovary and consequently decreases productivity. However, regulatory mechanisms that drive development remain elusive. Thus, we collected atrophic ovaries (AO) from 380-day-old broody chickens (BC) normal (NO) even-aged egg-laying (EH) for RNA sequencing. We identified 3,480 protein-coding transcripts were differentially expressed (DE), including 1,719 down-regulated 1,761 up-regulated AO. There 959 lncRNA DE, 56 903 up-regulated. Among the116...
Abstract Background: Since the domestication of red jungle fowls (Gallus gallus; dating back to ~10 000 B.P.) in Asia, domestic chickens gallus domesticus) have been subjected combined effects natural selection and human-driven artificial selection; this has resulted marked phenotypic diversity a number traits, including behavior, body composition, egg production, skin color. Population genomic variations through diversifying not fully investigated. Findings: The whole genomes 78 were...
Abstract The hypothalamic-pituitary-ovarian (HPO) axis regulates the breeding process cycle of laying hens. However, key regulatory genes HPO and pathways that drive chicken egg performance remain elusive. A total 856 Chinese Luhua was raised highest two hundred lowest production were considered as high (HEP) low (LEP) according to number at 300 days age, respectively. RNA-seq sequencing (RNA-Seq) conducted explore transcriptome from hypothalamus, pituitary gland ovary tissue 6 with 3...
T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. has been shown to induce a series of toxic effects on the health human and animal, such as immunosuppression carcinogenesis. Previous study proven that caused hepatotoxicity chicken, but regulatory mechanism unclear. In present study, we assessed toxicological effect apoptosis autophagy hepatocytes. The total 120 1-day-old healthy broilers were allocated randomly into four groups reared for 21...
There are hundreds of phenotypically distinguishable domestic chicken breeds or lines with highly specialized traits worldwide, which provide a unique opportunity to illustrate how selection shapes patterns genetic variation. many local in China.Here, we population genome landscape variations 86 chickens representing 10 diverse breeds. Genome-wide analysis indicated that sex chromosomes have less diversity and under stronger than autosomes during domestication adaptation. We found an...
Due to the increasing demand for producing chickens with high meat quality, there is a need determine its mode of action on chicken quality traits across wider age spectrum. In this study, five groups 200 male Da-Heng type birds were reared until slaughter 60, 90, 120, 150, 180 days old and breast muscle performance, traits, myofiber characteristics evaluated. The larger body weight are based diameter area, less density older than younger birds. There was an effect all (p < 0.05). Older...
Aflatoxin B1 (AFB1) leads to a major risk poultry and its residues in meat products can also pose serious threat human health. In this study, after feeding 165-day-old Roman laying hens for 35 days, the toxic effects of aflatoxin at different concentrations were evaluated. The purpose study was explore mechanism liver toxicosis responses AFB1. We found that highly group exposure resulted fat deposition, increased interstitial space, hepatocyte apoptosis hens. Furthermore, total 164...
MicroRNAs are evolutionarily conserved, small non-coding RNAs that play critical post-transcriptional regulatory roles in skeletal muscle development. We previously found miR-9-5p is abundantly expressed chicken muscle. Here, we demonstrate a new role for as myogenic microRNA regulates The overexpression of significantly inhibited the proliferation and differentiation satellite cells (SMSCs), whereas inhibition had opposite effect. show insulin-like growth factor 2 mRNA-binding protein 3...
The poultry ovary is used as a classic model to study ovarian biology and cancer. Stress factors induced oxidative stress cause follicle atresia, which may be fundamental reason for the reduction in fertility older laying hens or aging women. In present study, we set out characterize relationships between function. Layers (62 weeks of age; BW = 1.42 ± 0.12 kg) were injected with tert-butyl hydroperoxide (tBHP) at 0 (CON) 800 μmol/kg (oxidative group, OS) 24 days role melatonin (Mel) on...
As bioinformatic approaches have been developed it has demonstrated that microRNAs (miRNAs) are involved in the formation of muscles, and play important roles regulation muscle cell proliferation differentiation. Previously miR-148a-3p is one most abundant miRNAs chicken skeletal muscle. Here, we build on work demonstrate control differentiation satellite cells (SMSCs). Elevated expression significantly promoted inhibited apoptosis SMSCs but did not affect proliferation. Furthermore was...
Circular RNAs (circRNAs) are recognized as functional non-coding transcripts; however, emerging evidence has revealed that some synthetic circRNAs generate peptides or proteins. Additionally, the diverse biological functions of include acting miRNA-binding sponges, RNA-binding protein regulators, and translation templates. Previously, we found circular RNA circFAM188B is a stable differentially expressed between broiler chickens layers during embryonic skeletal muscle development. In this...
Zearalenone (ZEA) is a nonsteroidal estrogenic mycotoxin found in several food commodities worldwide. ZEA causes reproductive disorders, genotoxicity, and testicular toxicity animals. However, little known about the functions of apoptosis autophagy after exposure to granulosa cells. This study investigated effects on chicken The results show that at different doses significantly inhibited growth cells by inducing apoptosis. treatment up-regulated Bax downregulated Bcl-2 expression, promoted...
The growing period is a critical for growth and development in laying hens. During this period, chicks grow rapidly, but are accompanied by unstable digestive function, incomplete organ development, high mortality. Small peptide, feed additive, which has been proved to promote intestinal immunity poultry. In order elucidate the effects of small peptides on performance, immunity, antioxidant capacity, health hens, total 900 Tianfu green shell hens (1-day-old) were randomly divided into 5...
Long-term genetic selection for BW has generated high weight select (HWS) and low (LWS) lines of chickens. These show an approximate 10-fold difference in at age (d 56). The objective this study was to profile the expression master regulators early lineage specification (Pax3, Pax7) myogenic regulatory factors (Myf5, MyoD1, MyoG, Mrf4) on day hatch d 7, 28, 56 pectoralis major gastrocnemius muscles. There a line × interaction all 6 genes both In muscle, Pax3, Mrf4 showed greater LWS than HWS...
Artificial illumination is an important exogenous factor in the control of many physiological and behavioral processes management layers. The objective this study was to examine effect monochromatic light on reproductive traits, fertility, quality eggs local mountainous laying hens China. Five hundred fifty-two19-wk-old were randomly divided into 4 groups, with each group consisting 138 birds. Feed water provided ad libitum. Light treatments white (mini-incandescent bulbs), blue (480 nm),...
The high stocking density is a major stress factor that adversely affects the health and performance of poultry. Therefore, object this study was conducted to explore whether dietary 25-hydroxyvitamin D (25-OH-D3) could improve gut laying hens reared under density. A 2 × factorial design used in 16-week study, which 800 45-week-old Lohmann were allocated into two levels 25-OH-D3 (0 69 µg/kg) rates densities [506 (low density, LD) 338 (high HD) cm2/hen]. Compared with layers LD, HD had lower...
Oxidative stress (OS) is a key factor regulating the systemic pathophysiological effects and one of fundamental mechanisms associated with aging fertility deterioration. Previous studies revealed that resveratrol (RV) exhibits preventive effect against oxidative in ovary. However, it remains unknown whether gut microbiota respond to during an OS challenge. In Exp. 1, layers received intraperitoneal injection tert-butyl hydroperoxide (tBHP) (0 or 800 μmol/kg BW) diets 600 mg/kg) for 28 days....
Artificial illumination is widely used in modern poultry houses and different wavelengths of light affect production behaviour. In this study, we measure mRNA protein abundance estrogen receptors (ERs) progesterone (PRs) order to investigate the effect monochromatic on egg traits gonadal hormone function chicken ovarian follicles. Five hundred fifty-two 19-wk-old laying hens were exposed three lights: red (RL; 660 nm), green (GL; 560 blue (BL; 480 nm) control cool white (400–760 with an LED...