A5020773529- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Animal Nutrition and Physiology
- Photodynamic Therapy Research Studies
- Traditional Chinese Medicine Analysis
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Medicinal Plant Pharmacodynamics Research
- Livestock and Poultry Management
- Chromatography in Natural Products
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Cancer Research and Treatments
- Graphene and Nanomaterials Applications
- Autophagy in Disease and Therapy
- Porphyrin and Phthalocyanine Chemistry
- MicroRNA in disease regulation
- Berberine and alkaloids research
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
Peking University
2016-2025
Xichang University
2020-2024
Guangdong Academy of Medical Sciences
2022-2024
Central South University
2023-2024
Hunan University
2024
Third Xiangya Hospital
2023-2024
Southern Medical University
2022-2024
Guangdong Provincial People's Hospital
2022-2024
Peking University First Hospital
2024
Oklahoma State University
2020-2022
Immunotherapy through stimulating the host immune system has emerged as a powerful therapeutic strategy for various malignant and metastatic tumors in clinic. However, harnessing cancer treatment often fails to obtain durable response rate due poor immunogenicity strong immunosuppressive milieu tumor site. Herein, redox-activated liposome was developed from self-assembly of porphyrin–phospholipid conjugate coencapsulation indoleamine 2,3-dioxygenase (IDO) inhibitor into interior lumen via...
Tumour-associated macrophages (TAMs), as one of the most abundant tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and suppression. M2-like TAMs present heightened lysosomal acidity protease activity, limiting an effective cross-presentation. How to selectively reprogram reinvigorate anti-tumour responses is challenging. Here, we report pH-gated nanoadjuvant (PGN) that targets lysosomes tumours rather than corresponding organelles from healthy tissues....
Though zeolitic imidazole framework (ZIF) emerges as an advanced functional material for small‐molecule delivery due to its unique features such high loading and pH‐sensitive degradation, there are extreme short of knowledge regarding biological functions. To qualify this category vehicle, ZIF‐8 nanoparticles (ZIF‐NPs) with or without cargo engineered comprehensively investigated in vitro vivo. Interestingly, ZIF‐NPs demonstrate strong bioadhesion but limited internalization themselves,...
Abstract An ideal cancer nanomedicine should precisely deliver therapeutics to its intracellular target within tumor cells. However, the multiple biological barriers seriously hinder their delivery efficiency, leading unsatisfactory therapeutic outcome. Herein, pH/cathepsin B hierarchical‐responsive nanoconjugates (HRNs) are reported overcome these by sequentially responding extra‐ and stimuli in solid tumors for programmed of docetaxel (DTX). The HRNs have stable nanostructures (≈40 nm)...
Toll-like receptor (TLR) agonists are potent immune-stimulators that hold great potential in vaccine adjuvants as well cancer immunotherapy. However, TLR free form prone to be eliminated quickly by the circulatory system and cause systemic inflammation side effects. It remains a challenge achieve precise release of TLR7/8 agonist native at site endosomal compartments while keeping stable encapsulation inactive nontarget environment. Here, we report pH-/enzyme-responsive agonist-conjugated...
Anticancer immunotherapy is hampered by poor immunogenicity and a profoundly immunosuppressive microenvironment in solid tumors lymph nodes. Herein, sequential pH/redox-responsive nanoparticles (SRNs) are engineered to activate the immune of tumor sites The two-modular SRNs could sequentially respond acidic endosome compartments dendritic cells (DCs) precisely deliver doxorubicin (DOX) imidazoquinolines (IMDQs). In microenvironment, released DOX triggers immunogenic cell death. sentinel...
The hypothalamic-pituitary-ovarian (HPO) axis represents a central neuroendocrine network essential for reproductive function. Despite its critical role, the intrinsic heterogeneity within HPO across vertebrates and complex intercellular interactions remain poorly defined. This study provides first comprehensive, unbiased, cell type-specific molecular profiling of all three components in adult Lohmann layers Liangshan Yanying chickens. Within hypothalamus, pituitary, ovary, seven, 12, 13...
Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by treatment with collagenase has been proved effective enhancement interstitial transport and antitumor efficacy antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, which incorporated HER2-targeted monoclonal antibody trastuzumab (Col/Tra/Gel) for peritumoral administration. HER2-positvie BT474 tumor-bearing mice were selected as model. The Col/Tra/Gel showed continuous...
Abstract Male musk deer secrete from the gland located between their naval and genitals. Unmated male forest generate a greater amount of than mated males, potentially allowing them to attract number females. In this study, we used gas chromatography mass spectrometry (GC/MS) explore chemical composition pods captive unmated sexually mature Chinese next-generation sequencing intensively survey bacterial communities within them. Analysis showed that males have more muscone cholesterol....
In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.
Abstract Background: Since the domestication of red jungle fowls (Gallus gallus; dating back to ~10 000 B.P.) in Asia, domestic chickens gallus domesticus) have been subjected combined effects natural selection and human-driven artificial selection; this has resulted marked phenotypic diversity a number traits, including behavior, body composition, egg production, skin color. Population genomic variations through diversifying not fully investigated. Findings: The whole genomes 78 were...
Mucus, which is secreted by the goblet cells of enterocytes, constitutes first obstacle encountered for intestinal absorption nanomedicines. For decades, mucus has simply been regarded as a physical barrier that hinders permeation and drugs, because its high viscosity reticular structure, whereas interaction ingredients with nanomedicines usually neglected. It unclear whether glycoproteins, main components mucus, interact We also do not know how potential affects subsequent transportation...
Abstract The hypothalamic-pituitary-ovarian (HPO) axis regulates the breeding process cycle of laying hens. However, key regulatory genes HPO and pathways that drive chicken egg performance remain elusive. A total 856 Chinese Luhua was raised highest two hundred lowest production were considered as high (HEP) low (LEP) according to number at 300 days age, respectively. RNA-seq sequencing (RNA-Seq) conducted explore transcriptome from hypothalamus, pituitary gland ovary tissue 6 with 3...
There are hundreds of phenotypically distinguishable domestic chicken breeds or lines with highly specialized traits worldwide, which provide a unique opportunity to illustrate how selection shapes patterns genetic variation. many local in China.Here, we population genome landscape variations 86 chickens representing 10 diverse breeds. Genome-wide analysis indicated that sex chromosomes have less diversity and under stronger than autosomes during domestication adaptation. We found an...
Abstract Noninvasive imaging strategies have been extensively investigated for in vivo mapping of sentinel lymph nodes (SLNs). However, the current fail to accurately assess tumor metastatic status SLNs with high sensitivity. Here we report pH‐amplified self‐illuminating near‐infrared nanoparticles, which integrate chemiluminescence resonance energy transfer (CRET) and signal amplification strategy, enabling accurate identification SLNs. After draining into nodes, nanoparticles were...
Efficient delivery of payload to intracellular targets has been identified as the central principle for nanomedicine development, while extracellular are equally important cancer treatment. Notably, contribution extracellularly distributed nanoparticles therapeutic outcome is far from being understood. Herein, we develop a pH/light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN), which functions through sequentially lighting up and fluorescence signals by acidic...
Avian ovaries develop asymmetrically apart from prey birds, with only the left ovary growing more towards functional organ. Here, we analyze over 135,000 cells chick's and right at six distinct embryonic developmental stages utilizing single-cell transcriptome sequencing. We delineate gene expression patterns across 15 cell types within these embryo ovaries, revealing side-specific development. The exhibit cortex cells, zygotene germ transcriptional changes unique to side. Differential...