A5046112590- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Viral Infections and Vectors
- Plant Molecular Biology Research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Plant Reproductive Biology
- Plant nutrient uptake and metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Metal-Organic Frameworks: Synthesis and Applications
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Plant Stress Responses and Tolerance
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Graphene and Nanomaterials Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
Research Institute of Tropical Forestry
2025
Chinese Academy of Forestry
2025
Zhongkai University of Agriculture and Engineering
2025
The University of Texas Southwestern Medical Center
2020-2024
First Affiliated Hospital of Zhengzhou University
2014-2024
Nankai University
2023-2024
State Key Laboratory of Natural Medicine
2023-2024
China Pharmaceutical University
2022-2024
Health Commission of Anhui Province
2024
Ludong University
2023
Abstract The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that a target therapeutics for infectious diseases and cancer. However, early-phase clinical trials small-molecule STING agonists have shown limited antitumour efficacy dose-limiting toxicity. Here, we show polyvalent agonist—a pH-sensitive polymer bearing seven-membered ring with tertiary amine (PC7A)—activates innate-immunity pathways through the polymer-induced formation STING–PC7A...
Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it also serves as primary carbon fuel source for many cell types. In the tumor-immune microenvironment, effect lactate on cancer and immune cells can be highly complex hard to decipher, which further confounded by acidic protons, co-product glycolysis. Here we show that able increase stemness CD8
Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP in response to self or microbial cytosolic DNA as a danger signal. STING ubiquitously expressed diverse cell populations, including cancer cells, with distinct cellular functions, such activation type I interferons, autophagy induction, triggering apoptosis. It not well understood whether and which subsets stromal cells are particularly important for STING-mediated antitumor immunity. Here, using...
Though zeolitic imidazole framework (ZIF) emerges as an advanced functional material for small‐molecule delivery due to its unique features such high loading and pH‐sensitive degradation, there are extreme short of knowledge regarding biological functions. To qualify this category vehicle, ZIF‐8 nanoparticles (ZIF‐NPs) with or without cargo engineered comprehensively investigated in vitro vivo. Interestingly, ZIF‐NPs demonstrate strong bioadhesion but limited internalization themselves,...
The different actions of abscisic acid (ABA) in the aboveground and belowground parts plants suggest existence a distinct perception mechanism between these organs. Although characterization soluble ABA receptors PYR1/PYL/RCAR as well core signaling components has greatly advanced our understanding perception, signal transduction, responses, environment-dependent organ-specific sensitivity to is less understood. By performing real-time quantitative PCR assays, we comprehensively compared...
Abstract Stimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision diagnostic or therapeutic outcomes. In this study, we report design, synthesis characterization a series degradable ultra-pH sensitive (dUPS) polymers that amplify small acidic pH changes efficacious outputs. A hydrolytically active polycarbonate backbone is used construct polymer pH-dependent degradation kinetics....
Although cytotoxic treatments hold tremendous potential in boosting antitumor immunity, efferocytosis of tumor-associated macrophages (TAMs) could negatively remove apoptotic tumor cells through LC3-associated phagocytosis (LAP), resulting inefficient antigen presentation and immunosuppressive microenvironment. To address this issue, we developed TAM-targeting nanospores (PC-CW) inspired by the predominant tropism Rhizopus oryzae toward macrophages. construct PC-CW, disguised...
Combining immune checkpoint blockade with chemotherapy through nanotechnology is promising in terms of safety and efficacy. However, the distinct subcellular distribution each ingredient's action site makes it challenging to acquire an optimal synergism. Herein, a dual-pH responsive hybrid polymeric micelle system, HNP(αPDL1
ConspectusImmunotherapy has transformed the field of oncology and patient care. By leveraging immune system host, immunostimulatory compounds exert a durable, personalized response against patient's own tumor. Despite clinical success, overall rate from current therapies (e.g., checkpoint inhibitors) remains low (∼20%) because tumors develop multiple resistance pathways at molecular, cellular, microenvironmental levels. Unlike other oncologic therapies, harnessing antitumor immunity requires...
Abstract Auxins and their analogs are widely used to promote root growth, flower fruit development, yield in crops. The action characteristics application scope of various auxins different. To overcome the limitations existing auxins, expand applications, reduce side effects, it is necessary screen new auxin analogs. Here, we identified 3,4-dichlorophenylacetic acid (Dcaa) as having auxin-like activity acting through signaling pathway plants. At physiological level, Dcaa promotes elongation...
In recent years, some new “Qi-Nan” clones of Aquilaria sinensis with the characteristics easy induction and high-quality agarwood have been obtained, through cultivation propagation grafted seedlings. These are used for intensive production agarwood. The speed resin formation yield crucial development industry. differences in chemical composition among different Qi-Nan times worth investigating. While between ordinary A. extensively studied, effects time coupled on remain insufficiently...
Ferroptosis is one of the main mechanisms sorafenib against hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) plays an important role in heterogeneity, tumor metastasis, immunosuppressive microenvironment, and drug resistance HCC. However, there are few studies looking into relationship between ferroptosis EMT how they may affect prognosis HCC collectively.We downloaded gene expression clinical data patients from Cancer Genome Atlas (TCGA) International Consortium...
Background: Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies in world. Lamin B1 (LMNB1) a key component nuclear skeleton structure. Recent studies have found that LMNB1 overexpressed tumor tissues and associated with prognosis patients. However, underlying mechanism remains unclear HCC. Objective: This study aims to explore clinical significance molecular mechanisms Methods: The expression level its values were analyzed public databases, HCC adjacent normal was...
To design a prodrug-based self-assembling nanosystem with both ligand targeting and stimuli-responsive features, elucidate the superiority of each strategy synergistic effect between them, we synthesized four small molecule amphiphilic peptide-drug conjugates (APDCs) using maytansinoid (DM1) as cytotoxic agent, cRGDfK homing peptide, disulfide (SS) or thioether (SMCC) linker. Owing to their amphiphilicity, APDCs could self-assemble into nanoparticles (APDC@NPs) which were evaluated in vitro...
Among the diverse factors that may influence therapeutic outcomes, exocytosis of targeted drug delivery systems (TDDS) and its relationship with corresponding receptor receive little attentions. In this study, cRGDfK modified gold nanoparticles (cRGDfK-PEG-AuNPs) were synthesized, their cellular transportation including endocytosis exocytosis, as well potential relations αvβ3 integrin carefully studied. The results showed enhanced fast internalization cRGDfK-PEG-AuNPs into U87 cells was...
Background: As an active ingredient of Chinese herbal medicine, quercetin (QU) can significantly induce apoptosis tumor cells and give play to other effect such as decreasing both fibroblast population collagen in cancer cell nest. However, the antitumor efficacy was mostly evaluated at cellular level rarely developed vivo by intravenous injection, which may be ascribed its inferior physicochemical properties including water insolubility, short plasma half-time, insufficient enrichment...