A5080683538- Congenital Diaphragmatic Hernia Studies
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Endometriosis Research and Treatment
- Hair Growth and Disorders
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Metabolism and Diseases
- melanin and skin pigmentation
- Renal and related cancers
- Apelin-related biomedical research
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Birth, Development, and Health
- Uterine Myomas and Treatments
- Ovarian function and disorders
- Esophageal and GI Pathology
- Drug Transport and Resistance Mechanisms
- Congenital Anomalies and Fetal Surgery
- CRISPR and Genetic Engineering
- Pleural and Pulmonary Diseases
- Bone health and treatments
- Spaceflight effects on biology
Shandong University
2022-2025
Shandong First Medical University
2022-2024
Shandong Tumor Hospital
2022-2024
Shenzhen Institutes of Advanced Technology
2018-2024
Chinese Academy of Sciences
2013-2024
Children's Hospital
2023
Shenzhen University Health Science Center
2022
Institute of Zoology
2011-2016
University of Wisconsin–Madison
2015-2016
University of Chinese Academy of Sciences
2013-2015
The mammalian embryonic lethal abnormal vision (ELAV)-like protein HuD is a neuronal RNA-binding implicated in development, plasticity, and diseases. Although has long been associated with the functions of neural stem cell differentiation underlying mechanisms have gone largely unexplored. Here we show that promotes stem/progenitor cells (NSCs) adult subventricular zone by stabilizing mRNA special adenine-thymine (AT)-rich DNA-binding 1 (SATB1), critical transcriptional regulator...
Human patient-derived induced pluripotent stem cells (hiPSCs) provide unique opportunities for disease modeling and drug development. However, adapting hiPSCs or their differentiated progenies to high throughput assays phenotyping screening has been challenging. Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability a major genetic autism. FXS caused by mutational trinucleotide expansion in FMR1 gene leading hypermethylation silencing. One potential...
Chemerin and G protein-coupled receptor 1 (GPR1) are increased in serum placenta mice during pregnancy. Interestingly, we observed chemerin levels decreased GPR1 expression of high-fat-diet-fed compared with chow-fed at gestational day 18. protein gene were significantly diabetes mellitus (GDM) patient placentas. Therefore, hypothesized that chemerin/GPR1 signaling might participate the pathogenic mechanism GDM. We investigated role carbohydrate homeostasis pregnancy using pregnant...
This case report presents the diagnosis and treatment process of a rare gastric perforation caused by short hair, leading to formation foreign body granuloma in child. The patient was 3-year-old boy who admitted hospital with persistent abdominal pain fever for more than 20 days. Ultrasound CT revealed inflammatory encapsulation cavity. Laparoscopic open surgeries were performed, revealing full-thickness wall approximately 2 mm diameter on greater curvature side stomach, which contact...
Reports of bronchopulmonary sequestration in two or more locations within the ipsilateral thorax children are rare. To date, only a few clinical reports have described thoracoscopic two-port treatment for external lobe sequestration. We performed surgery on 7-month-old girl and identified abnormal masses left thoracic cavity: one located upper hilum lung other surface lower diaphragm. Both were resected using two-aperture pathologically confirmed as extralobar sequestrations. Preoperative...
G protein-coupled receptors (GPCRs) mediate multiple key biological processes in the body. The orphan receptor GPR39 has been reported to be involved various pathophysiological events. However, function of skin biology remains unknown. Using a genetically engineered mouse strain which lacZ expression faithfully replaced endogenous Gpr39 expression, we discovered unique pattern sebaceous gland (SG). methods, confirmed that marked specific cell population at opening SG and colocalised with...
Microgravity has been shown to induces many changes in proliferation, differentiation and growth behavior of stem cells. Little is known about the effect microgravity on hematopoietic pluripotent cells (PSCs). In this study, we used random position machine (RPM) investigate whether simulated (SMG) allows induction stem/progenitor cell (HSPC) derived from human embryonic (hESCs) vitro. The results showed that SMG facilitates hESCs differentiate HSPC with more efficient CD34+CD31+ hemogenic...
R-spondin proteins are novel Wnt/β-catenin agonists, which signal through their receptors leucine-rich repeat-containing G-protein coupled receptor (LGR) 4/5/6 and substantially enhance activity. R-spondins reported to function in embryonic development. They also play important roles stem cell functions adult tissues, such as the intestine mammary glands, largely rely on signaling. However, skin epithelium hair follicles, information about is deficient, although expressions of receptors,...
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and functions at implantation, but manifestation of its phenotypes in late pregnancy. There no reliable method for early prediction treatment EOPE. Adrenomedullin (ADM) an abundant placental peptide Integrated single-cell sequencing spatial transcriptomics confirm high ADM expression the human villous cytotrophoblast syncytiotrophoblast. The levels chorionic villi serum...
Hair follicle stem cells (HFSCs) possess fascinating self-renewal capacity and multipotency, which play important roles in mammalian hair growth skin wound repair. Although HFSCs from other species have been obtained, the characteristics of ovine HFSCs, as well methods to isolate them not addressed. Here, we report an efficient strategy obtain multipotent HFSCs. Through microdissection organ culture, obtained keratinocytes that grew bulge area vibrissa follicles, even abundant were harvested...
In rodent species, the ovary and end of oviduct are encapsulated by a thin membrane called ovarian bursa. The biological functions bursa remain unexplored despite its structural arrangement in facilitating oocytes transport into oviduct. present study, we observed rapid fluid accumulation reabsorption within after stimulation (PMSG-primed hCG injection), suggesting that might play an active role regulating local homeostasis around timing ovulation. We hypothesized aquaporin proteins, which...
The liver is an essential multifunctional organ, which constantly communicates with nearly all tissues. It has raised the concern that microgravity exposure can lead to dysfunction and metabolic syndromes. However, molecular mechanisms intervention measures of adverse effects on hepatocytes are limited. In this study, we utilized random positioning machine culture system investigate under simulated (SMG). Our results showed SMG impaired hepatocyte viability, causing cell cycle arrest...
Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target rapamycin (mTOR) a key regulator cellular metabolism in the body. Inhibition mTOR signaling causes postimplantation development failure, yet mechanisms are still poorly understood.Pregnancy mice preimplantation mouse were treated with inhibitor vivo vitro respectively, subsequently examined blastocyst formation, implantation, post-implantation...
The occurrence of simultaneous extralobar pulmonary sequestration, esophageal duplication, and bronchogenic cysts is relatively low. We report the case a 9-month-old Chinese child who had right lung cyst, detected in utero was closely monitored until birth. At age 9 months, contrast-enhanced computed tomography revealed mediastinal sequestration two cysts. patient did not exhibit any abnormalities. However, parents were concerned about disease. Following positive psychological counseling to...
Background Congenital pulmonary sequestration is a rare lung anomaly that can be classified as intralobar or extralobar (ELS). Infradiaphragmatic type of ELS. Furthermore, intrathoracic kidney (ITK) disease associated with congenital diaphragmatic hernia (CHD) in 0.25% cases. We report the first case infradiaphragmatic and ITK CDH child. Case management The patient, male, aged 6 months, visited our hospital 2 months prior due to shortness breath. Based on chest ultrasonography enhanced...
Throughout a woman’s reproductive life, hundreds of functioning follicles are activated for development, while thousands dormant remain in the ovaries. Dormant follicle activation vitro is an effective clinical strategy women with fertility needs who suffer from ovarian dysfunction. However, activating vivo still challenge due to difficulties such as delivering stimulators local sites. Here, we developed compound-preloaded microporous scaffold by combining three-dimensional (3D)...
Hair follicle stem cells (HFSCs) are considered one of the useful donor cell types for skin regenerative medicine owing to their robust proliferative capacity and multipotency. However, methods easily effectively obtaining HFSCs from a limited biopsy still lacking. Here we report novel approach subpopulation small sample rat tail, which uses sebaceous glands (SGs) capture adjacent HFSCs. By means organ culture, keratinocytes were expanded detached SGs, also included adherent hair that could...
Excess androgen-induced obesity has become a public health problem, and its prevalence increased substantially in recent years. Chemokine-like receptor 1 (CMKLR1), of chemerin secreted by adipose tissue, is linked to adipocyte differentiation, tissue development, obesity. However, the effect CMKLR1 signaling on androgen-mediated adiposity vivo remains unclear. Using CMKLR1-knockout mice, we constructed an androgen-excess female mouse model through 5α-dihydrotestosterone (DHT) treatment...