A5100753426- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
- Medical Imaging and Pathology Studies
- Virus-based gene therapy research
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Fluorine in Organic Chemistry
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Intensive Care Unit Cognitive Disorders
- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Advanced Radiotherapy Techniques
China Medical University
2021-2025
First Hospital of China Medical University
2021-2025
Shanxi Medical University
2022-2025
Sun Yat-sen University Cancer Center
2015-2025
Sun Yat-sen University
2015-2025
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2011-2024
Shandong University
2022-2024
Zhejiang Lab
2024
Software (Spain)
2024
A critical bottleneck for the credibility of artificial intelligence (AI) is replicating results in diversity clinical practice. We aimed to develop an AI that can be independently applied recover high-quality imaging from low-dose scans on different scanners and tracers.
Abstract Despite the potential of deep learning (DL)-based methods in substituting CT-based PET attenuation and scatter correction for CT-free imaging, a critical bottleneck is their limited capability handling large heterogeneity tracers scanners imaging. This study employs simple way to integrate domain knowledge DL In contrast conventional direct methods, we simplify complex problem by decomposition so that anatomy-dependent can be achieved robustly low-frequency while original...
Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role NPC is unclear. Objective To evaluate the efficacy and safety adjuvant for NPC. Design, Setting, Participants Randomized, open-label, multicenter, phase 3 clinical trial conducted...
Extranodal natural killer/T cell lymphoma (ENKL), nasal type is a kind of rare disease with low survival rate that primarily affects Asian and South American populations. Segmentation ENKL lesions crucial for clinical decision support treatment planning. This paper the first study on computer-aided diagnosis systems segmentation problem. We propose an automatic, coarse-to-fine approach using adversarial networks. In coarse stage, we extract region interest bounding utilizing neural network....
To develop a weakly supervised deep learning (WSDL) method that could utilize incomplete/missing survival data to predict the prognosis of extranodal natural killer/T cell lymphoma, nasal type (ENKTL) based on pretreatment 18F-FDG PET/CT results.One hundred and sixty-seven patients with ENKTL who underwent were retrospectively collected. Eighty-four followed up for at least 2 years (training set = 64, test 20). A WSDL was developed enable integration remaining 83 follow-up information in...
Abstract Objectives We aimed to investigate the role of [ 68 Ga]FAPI-04 and 18 F]FDG dual-tracer PET/CT for initial assessment gastric cancer explore factors associated with their uptake. Methods This study enrolled 62 patients histopathologically confirmed cancer. compared diagnostic performance Ga]FAPI-04, F]FDG, combined PET/CT. The standardized uptake value (SUV) tumor-to-background ratio (TBR) were also measured, that influence tracer analyzed. Results detected more primary lesions...
QiXueHe Capsule (QXHC) is a Chinese patent drug that extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated. A list QXHC putative targets were predicted using MetaDrug. An interaction network links between and known therapeutic disorders was constructed. candidate also identified via calculating topological feature values nodes in network. Additionally, molecular docking simulation performed to determine...
Increased glucose utilization is a hallmark of cancer, and tumor metabolism emerging as anticancer target for therapeutic intervention. Triple-negative breast cancers TNBC are highly glycolytic show poor clinical outcomes. We previously identified hexokinase 2, the major enzyme, gene miR-143 in TNBC. Here, we developed formulation using cholesterol-modified agomir encapsulated neutral lipid-based delivery agent that blocked growth tumor-bearing mice when administered systemically. The...
Femtosecond laser with pulse duration of 35 fs is used to introduce optical breakdown in water and ethanol. The initial dynamics the laser-introduced break down investigated a time resolved shadow imaging method. motion shock wave front at 600 ps, 4 ns, 12 16 20 ns are observed. Experimental results indicate that under same energy, velocity generated ethanol slightly lower than water. This mainly determined by liquid properties (viscosity coefficient, density, molecular weight, threshold)....
Bone-marrow mesenchymal stem cells (BMSCs) have been used for systemic delivery of therapeutic genes to solid tumors. However, the optimal treatment time post-BMSC implantation and assessment long-term fate BMSCs post-tumor are critical if such promising therapies be translated into clinical practice. An efficient BMSC-based strategy has developed that simultaneously allows killing tumor cells, inhibiting angiogenesis, eradication implanted after glioblastoma. were engineered co-express...
Different combinations of biomarkers analyzed by flow cytometry are critical for the accurate diagnosis leukemic B-cell chronic lymphoproliferative disorders (B-CLPDs). We investigated CD200 and CD148 expression patterns blood or bone marrow from 374 cases B-CLPD multicolor cytometry. Our results showed that distinguished different types B-CLPD. mean fluorescence intensity (MFI) MFI had a high sensitivity specificity to differentiate mantle cell lymphoma (MCL) lymphocytic leukemia (CLL)....
Abstract This study is to evaluate the efficacy of additional concurrent chemotherapy for intermediate risk (stage II and T3N0M0) NPC patients treated with intensity-modulated radiotherapy (IMRT).440 were studied retrospectively, including 128 IMRT alone [radiotherapy group (RT group)] 312 paitents plus [chemoradiotherapy (CRT group)]. Propensity score matching was carried out create RT CRT cohorts equally matched host tumor factor. Significantly more severe acute toxicities observed in than...
To investigate the role of 99mTc-labeled sestamibi (99mTc-MIBI) retention level in assessment malignant potential parathyroid lesions.Twenty patients with carcinomas and forty controls benign lesions who underwent preoperatively 99mTc-MIBI dual-phase planar SPECT/CT imaging were retrospectively enrolled this study. The mean peak index (RImean RIpeak) measured for evaluating lesions. Diagnostic accuracies RI differentiating from ones assessed by receiver operating characteristic analyses...
Varroa destructor is an obligate ectoparasite of honey bees and shifted from its original host Apis cerana to the new mellifera in first half twentieth century. The shift has resulted a great threat health survival A. colonies worldwide. Chemical signals play crucial role all aspects life cycle, including finding. However, chemical cues that affect finding behavior mites are still not fully understood. In this study, we systematically profiled headspace volatiles both worker drone larvae two...
Low voltage electric field (LVEF) thawing has been shown to be an effective method of thawing. In this study, chicken breast meat was thawed in a fixed (2.5 KV), and the process divided into two stages: stage Ⅰ (−20 °C −5 °C) Ⅱ (−5 −1 °C). The effects two-stage air based on low (TLT) quality were investigated by altering temperature (T1 T2) stages. results showed that TLT could significantly (P<0.05) reduce time loss than Among them, TLT22.5–7.5 samples almost retained same tissue structure...
The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by Egr1 following 131I treatment. However, rapid outflow restricted radiotherapy effect. To overcome this barrier, ultrasmall gold nanoclusters (usAuNCs) were used enhance efficacy Egr1-hNIS for its radiation sensitization. In work, we prepared "cell bomb" BMSCs carrying both GSH@AuNCs Egr1-hNIS. We found that target TNBC tumor reach a...
<h2>Abstract</h2> Anti-myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) associated disorder (MOGAD) is an immune-mediated central nervous system (CNS) inflammatory demyelinating that has been widely recognized in recent years. It distinct from multiple sclerosis (MS) and neuromyelitis optica spectrum (NMOSD), which are separate disease spectrums. Here we report the case of a 5-year-old boy who was admitted for 3 days with fever, headache, vomiting. Magnetic resonance imaging...