A5034416132- Medical Imaging Techniques and Applications
- Constraint Satisfaction and Optimization
- Glioma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Resistance in Bacteria
- Radiomics and Machine Learning in Medical Imaging
- RNA Interference and Gene Delivery
- Advanced Biosensing Techniques and Applications
- Computational Drug Discovery Methods
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Biosensors and Analytical Detection
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Viral Infections and Immunology Research
- UAV Applications and Optimization
- Mycobacterium research and diagnosis
- Cancer Research and Treatments
- Distributed Control Multi-Agent Systems
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Antifungal resistance and susceptibility
Sun Yat-sen University
2015-2024
Shanghai Institute of Materia Medica
2024
Chinese Academy of Sciences
2024
Third Affiliated Hospital of Sun Yat-sen University
2015-2024
Zhejiang Cancer Hospital
2024
University of Chinese Academy of Sciences
2024
Shanghai Jiao Tong University
2014-2023
Ruijin Hospital
2012-2023
City University of New York
2010-2021
The Graduate Center, CUNY
2012-2021
Background Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity. However, the supporting evidence on relationship between BAT and central obesity metabolic profile large population based is sparse. Methodology/Principal Findings We studied 4011 (2688 males 1323 females) tumor-free Chinese adults aged 18-89 for activities, visceral/subcutaneous fat areas (VFA/SFA), waist circumferences (WC) parameters. found...
Rosmarinic acid (RA) has a wide range of biological effects, including the antioxidation and antiaging. However, detailed mechanisms remain unclear but highly attractive. Herein, RA promoted lifespan motoricity in dose-dependent manner, reduced fat store without threatening fertility Caenorhabditis elegans. In term antioxidant efficacy, catalase activity, glutathione peroxidas content, glutathione/oxidized ratio were enhanced. And malondialdehyde content was diminished significantly....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of oligodeoxynucleoside phosphorodithioates via thioamiditesWolfgang K. D. Brill, Jin Yan Tang, Yun Xi Ma, and Marvin H. CaruthersCite this: J. Am. Chem. Soc. 1989, 111, 6, 2321–2322Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00188a066https://doi.org/10.1021/ja00188a066research-articleACS PublicationsRequest reuse permissionsArticle...
In this research, an important topic of cooperative search for multi-dynamic targets in unknown sea area by unmanned aerial vehicle (UAV) is studied based on improved multi-ant colony theory (IMAC). A specialized multi-UAV map established, which a novel target probability (TPM) was designed to reduce the impact uncertainties caused dynamics targets. Then, transfer rules cell were determined improving behavior criterion ant algorithm and updating principle pheromone map. Finally, performance...
BackgroundProtein and antibody arrays have emerged as a promising technology to study protein expression function in high-throughput manner. These also represent new opportunity profile levels cancer patients' samples identify useful biosignatures for clinical diagnosis, disease classification, prediction, drug development patient care. We applied discover panel of proteins which may serve biomarkers distinguish between patients with ovarian normal controls. Methodology/Principal...
Abstract Glucose metabolic reprogramming, known as the Warburg effect, is one of hallmarks tumor cells. Cancer cells preferentially metabolize glucose by glycolysis rather than mitochondrial oxidative phosphorylation regardless oxygen availability, but regulatory mechanism underlying this switch has been incompletely understood. Here, we report that circular RNA circ ankyrin repeat domain 17 (ANKRD17) functions a key regulator for to promote cell growth, migration, invasion, and cell‐cycle...
Children of severe hand, foot, and mouth disease (HFMD) often present with same clinical features as those mild HFMD during the early stage, yet later deteriorate rapidly a fulminant course. Our goal was to: (1) develop machine learning system to automatically identify cases high risk at time admission; (2) compare effectiveness new existing scoring system. Data on 2,532 children admitted between March 2012 July 2015, were collected retrospectively from medical center in China. By applying...
The objective of this study was to determine the most effective way use dual-phase F-fluoro-2-deoxy-D-glucose (F-FDG) PET/computed tomography (CT) semiquantitative indices predict prognosis in patients with pancreatic cancer and guide treatment.Prognostic parameters were retrospectively analyzed 40 histologically proven who received F-FDG PET/CT at Ruijin Hospital. Maximum standardized uptake values (SUVs) determined 1 h (SUV1) 2 (SUV2) after injection. retention index (RI) defined as...
Abstract Therapeutic benefits and underlying biomechanism(s) of antibody drug conjugates (ADC) in combination with other targeted therapeutics are largely unknown. Here, the synergy between ADC epigenetic decitabine (DAC), a clinically approved DNA methylation inhibitor, multiple preclinical models melanoma specifically investigated. Mechanistically, biomechanisms how DAC cooperatively worked ICAM1 conjugated topoisomerase I inhibitor DXd (I1‐DXd) is elucidated. treatment significantly...
The overexpression of ATP-binding cassette (ABC) transporters is one the important mechanisms multidrug resistance (MDR). Some tyrosine kinase inhibitors (TKIs) such as CM082 might be a potential ABC transporter inhibitor, thus potentially reversing MDR. We used 3-(4,5-dimethylthiazol-2-yl)-2,5-dimethyltetrazolium bromide (MTT) assay to determine cytotoxicity and reversal effect CM082. A xenograft model was established evaluate MDR efficacy in vivo. intracellular accumulation efflux ABCG2...