A5068612123- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- interferon and immune responses
- Plant Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Genomics and Phylogenetic Studies
- Advanced Photocatalysis Techniques
- Toxoplasma gondii Research Studies
- Cell death mechanisms and regulation
- Bacteriophages and microbial interactions
- Genetic Mapping and Diversity in Plants and Animals
- Toxin Mechanisms and Immunotoxins
- Immunotherapy and Immune Responses
- Ammonia Synthesis and Nitrogen Reduction
- RNA Interference and Gene Delivery
Shenyang Agricultural University
2023-2025
Qinghai Normal University
2024-2025
Huizhou Central People's Hospital
2025
Ruijin Hospital
2023-2025
Institute of Microbiology
2025
Chinese Academy of Sciences
2025
Taipei Medical University
2019-2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Anhui University
2024
Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) over a decade, but its benefits are limited by acquired resistance, process that remains incompletely understood. Here we report an enhancer, located between promoters marker proliferation Ki67 (MKI67) and O6-methylguanine-DNA-methyltransferase (MGMT) genes, is activated in TMZ-resistant patient-derived xenograft (PDX) lines recurrent tumor samples. Activation enhancer correlates with increased MGMT expression, major known...
IL15, a potent stimulant of CD8(+) T cells and natural killer (NK) cells, is promising cancer immunotherapeutic. ALT-803 complex an IL15 superagonist mutant dimeric receptor αSu/Fc fusion protein that was found to exhibit enhanced biologic activity in vivo, with substantially longer serum half-life than recombinant IL15. A single intravenous dose ALT-803, but not eliminated well-established tumors prolonged survival mice bearing multiple myeloma. In this study, we extended these findings...
• Using pharmacological and biochemical approaches, the role of cadmium (Cd)-induced carbon monoxide (CO) release relationship between CO oxidative stress conferred by Cd exposure in root tissues alfalfa (Medicago sativa) plants were investigated. treatments showed a dose-dependent enhancement lipid peroxidation. Both 100 200 µm CdCl2 caused increase release, which is consistent with changes activity synthetic enzyme heme oxygenase (HO) its HO-1 transcript. A enhanced formation nonprotein...
Abstract Improving the effectiveness of adipose‐tissue derived human mesenchymal stromal/stem cells (AMSCs) for skeletal therapies requires a detailed characterization mechanisms supporting cell proliferation and multi‐potency. We investigated molecular phenotype AMSCs that were either actively proliferating in platelet lysate or basal non‐proliferative state. Flow cytometry combined with high‐throughput RNA sequencing (RNASeq) RT‐qPCR analyses validate express classic surface markers (e.g.,...
Anti-CD20 monoclonal antibodies (mAb) are an important immunotherapy for B-cell lymphoma, and provide evidence that the immune system may be harnessed as effective lymphoma treatment approach. ALT-803 is a superagonist IL-15 mutant IL-15Rα-Fc fusion complex activates receptor constitutively expressed on natural killer (NK) cells. We hypothesized would enhance anti-CD20 mAb-directed NK-cell responses antibody-dependent cellular cytotoxicity (ADCC).We tested this hypothesis by adding...
This study demonstrates the dependence of non-local susceptibility effects on object orientation in gradient echo MRI and reduction by deconvolution using quantitative mapping. Imaging experiments were performed a 3T system spoiled 3D multi-echo GRE sequence phantoms known susceptibilities, human brains healthy subjects patients with intracerebral hemorrhages. Magnetic field measurements determined from multiple phase data. To determine mapping, these deconvolved through dipole inversion...
The Chinese virulent (CHv) strain of duck enteritis virus (DEV) has a genome approximately 162,175 nucleotides with GC content 44.89%. Here we report the complete genomic sequence and annotation DEV CHv, which offer an effective platform for providing authentic research experiences to novice scientists. In addition, knowledge this will extend our general be useful further studies mechanisms replication pathogenesis.
IL-15 and its receptor α (IL-15Rα) are co-expressed on antigen-presenting cells, allowing transpresentation of to immune cells bearing IL-2RβγC stimulation effector responses. We reported previously that the high-affinity interactions between an superagonist (IL-15N72D) extracellular IL-15Rα sushi domain (IL-15RαSu) could be exploited create a functional scaffold for design multivalent disease-targeted complexes. The IL-15N72D·IL-15RαSuFc complex, also known as ALT-803, is multimeric complex...
Glycosylation of biomolecules can greatly alter their physicochemical properties, cellular recognition, subcellular localization, and immunogenicity. reactions rely on the stepwise addition sugars using nucleotide diphosphate (NDP)-sugars. Making these substrates readily available will accelerate characterization new glycosylation reactions, elucidation underlying regulation mechanisms, production glycosylated molecules. In this work, we engineered Saccharomyces cerevisiae to heterologously...