A5075030656- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound in Clinical Applications
- Medical Imaging and Pathology Studies
- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Pelvic and Acetabular Injuries
- Boron Compounds in Chemistry
- Congenital Heart Disease Studies
- Nuclear Physics and Applications
- Seismic Waves and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Spine and Intervertebral Disc Pathology
- Congenital Diaphragmatic Hernia Studies
- Organ Transplantation Techniques and Outcomes
University of Bern
2022-2025
University Hospital of Bern
2022-2025
Klinik und Poliklinik für Nuklearmedizin
2022-2025
University Hospital of Zurich
2014-2022
University of Zurich
2017-2022
ETH Zurich
2021-2022
Siemens Healthcare (Germany)
2022
Medical Solutions
2022
Nippon Medical School
2017
Abstract Purpose Ultrasound-guided biopsy (US biopsy) with 10–12 cores has a suboptimal sensitivity for clinically significant prostate cancer (sigPCa). If US is negative, magnetic resonance imaging (MRI)–guided recommended, despite low specificity lesions score 3–5 on Prostate Imaging Reporting and Data System (PIRADS). Screening guidance using an modality high accuracy could reduce the number of unnecessary biopsies, reducing side effects. The aim this study was to assess performance...
Abstract Despite the potential of deep learning (DL)-based methods in substituting CT-based PET attenuation and scatter correction for CT-free imaging, a critical bottleneck is their limited capability handling large heterogeneity tracers scanners imaging. This study employs simple way to integrate domain knowledge DL In contrast conventional direct methods, we simplify complex problem by decomposition so that anatomy-dependent can be achieved robustly low-frequency while original...
Abstract Objective Long axial field-of-view (LAFOV) PET/CT showed improved performance resulting from higher sensitivity. The aim was to quantify the impact of using full acceptance angle (UHS) in image reconstructions with Biograph Vision Quadra LAFOV (Siemens Healthineers) compared limited (high sensitivity mode, HS). Methods 38 oncological patients examined on a were analysed. 15 underwent [ 18 F]FDG-PET/CT, F]PSMA-1007 PET/CT, and 8 68 Ga]Ga-DOTA-TOC PET/CT. Signal-to-noise ratio (SNR)...
Abstract Purpose High blood glucose (hBG) in patients undergoing [ 18 F]FDG PET/CT scans often results rescheduling the examination, which may lead to clinical delay for patient and decrease productivity department. The aim of this study was evaluate whether long-axial field-of-view (LAFOV) can minimize effect altered bio-distribution hBG is able provide diagnostic image quality situations. Materials methods Oncologic with elevated (≥ 8.0 mmol/l) normal (< mmol/l, nBG) levels were matched...
Purpose To determine the level of clinically acceptable reduction in injected fluorine 18 (18F) fluorodeoxyglucose (FDG) dose time-of-flight (TOF)-positron emission tomography(PET)/magnetic resonance (MR) imaging by using silicon photomultiplier (SiPM) detectors compared with TOF-PET/computed tomography (CT) Lu1.8Y0.2SiO5(Ce), or LYSO, patients different body mass indexes (BMIs). Materials and Methods Patients were enrolled this study as part a larger prospective purpose than evaluated...
Abstract Background We assessed and compared image quality obtained with clinical 18 F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT two conventional PMT-based devices. Our goal was to evaluate an improved trade-off between administered activity (patient dose exposure/signal-to-noise ratio) acquisition time comfort) while preserving diagnostic information achievable the recently introduced detector technology previous analogue technology....
Performing 2-[18F]FDG PET/CT in addition to a PSMA-ligand can assist the detection of lesions with low PSMA expression and may help prognostication identification patients who likely benefit from PSMA-radioligand therapy (PSMA-RLT). However, cost time needed for separate examination might hinder its routine implementation. In this communication, we present our initial experiences additional low-dose as part dual-tracer same-day imaging protocol which exploits higher sensitivity exhibited by...
Evaluation of
Purpose To compare the radiation exposure for participants and interventionalists as well participant outcomes between fluoroscopy-guided versus CT-guided lumbar spinal injections. Materials Methods This prospective, nonrandomized observational study included 1446 (mean age, 60.6 years; range, 18–91 years) who received transforaminal epidural injections or facet joint under fluoroscopic CT guidance October 2009 April 2016. Effective doses were estimated by conversion from dose-area product...
The DMI PET/CT is a modular silicon photomultiplier-based scanner with an axial field-of-view (FOV) between 15 and 25 cm depending on ring configuration (3, 4, or 5 rings). A new generation of the system includes reengineered detector module, featuring improved electronics additional 6th ring, extending FOV to 30 cm. We report performance evaluation 6-ring upgraded Generation 2 (Gen2) while values are also reported for 5-ring very same prior upgrade.PET was evaluated using NEMA NU 2-2018...
The physical properties of yttrium-90 (
Ziel/Aim: Renogram activity curves from scintigraphy data are essential for assessing renal function and identifying pathologies. Although software solutions can generate renogram data, report writing remains manual. Large language models (LLMs) could streamline extraction automate writing, enhancing efficiency in clinical workflows. This study explores the feasibility of using LLMs automated generation, starting with textbook cases expanding to routine scans.
Abstract Pulmonary complications are known to occur in patients after Fontan palliation. Cardiac MRI is performed the follow-up of assess single ventricular function, hemodynamics and potential collateral flow. To date, pulmonary function tests have been used detect functional lung impairment, but has not integrated into imaging follow-up. In this study, we measured lung-to-background ratio (LBR) on zero echo time (ZTE) sequences 32 children with Patients were divided 2 groups: LBR > 1.5...
Abstract Objectives The number of patients receiving radioligand therapy (RLT) has risen sharply in recent years. This raises concerns about possible risks to dental healthcare workers due their exposure the and saliva. We therefore set measure salivary radioactivity undergoing 177 Lu–RLT. Materials methods recruited in-house RLT [ Lu]Lu -DOTA-TOC ( n = 6) or Lu]Lu-PSMA-I&T 14). measured concentrations 1 ml saliva samples collected before 0.5, 2, 4, 21, 27, 45 h post application...
Purpose To evaluate the possible activity reduction in FDG-imaging a Time-of-Flight (TOF) PET/MR, based on cross-evaluation of patient-based NECR (noise equivalent count rate) measurements PET/CT, cross referencing with phantom-based curves as well initial evaluation TOF-PET/MR reduced activity. Materials and Methods A total 75 consecutive patients were evaluated this study. PET/CT imaging was performed (time-of-flight Discovery D 690 PET/CT). Initial PET/MR newly available simultaneous...
Abstract Purpose Prostate-specific membrane antigen (PSMA)-targeted PET is increasingly used for staging prostate cancer (PCa) with high accuracy to detect significant PCa (sigPCa). [ 68 Ga]PSMA-11 PET/MRI-guided biopsy showed promising results but also persisting limitation of sampling error, due impaired image fusion. We aimed assess the possibility intraoperative quantification 18 F]PSMA-1007 PET/CT uptake in core biopsies as an instant confirmation accurate lesion sampling. Methods In...
Magnetic resonance (MR)-based attenuation correction is a critical component of integrated positron emission tomography (PET)/MR scanners. It generally achieved by segmenting MR images into tissue classes with known properties (e.g., bone, fat, soft tissue, lung, air). Ultra-short echo time (UTE) have been proposed in the past to locate bone tissue. In this study, tri-modality computed data was used develop an improved algorithm for localization head and neck.Twenty patients were scanned...
The image quality characteristics of two NEMA phantoms with yttrium-90 (90Y) were evaluated on a long axial field-of-view (AFOV) PET/CT. purpose was to identify the optimized reconstruction setup for imaging patients hepatocellular carcinoma after 90Y radioembolization.Two used, where one had 1:10 sphere background activity concentration ratio and second cold background. Reconstruction parameters used are as follows: iterations 2 8, Gaussian filter 2- 6-mm full-width-at-half-maximum,...
MRI of lung parenchyma is challenging because the rapid decay signal by susceptibility effects aerated on routine fast spin-echo sequences.To assess intensity in children ultrashort echo-time sequences comparison to a technique.We conducted retrospective study obtained 30 patients (median age 5 years, range 2 months 18 years) including 15 with normal lungs and cystic fibrosis. On sequence radial readout an sequence, both were segmented intensities extracted. We compared lung-to-background...
Purpose: The physical properties of yttrium-90 (90Y) allow for imaging with positron emission tomography/computed tomography (PET/CT). increased sensitivity long axial field-of-view (LAFOV) PET/CT scanners possibly allows to overcome the small branching ratio production from 90Y decays and improve post-treatment dosimetry selective internal radiation therapy. Methods: For challenging case an image quality body phantom, we compare a full Monte Carlo (MC) dose calculation results two...
We report the dosimetric evaluation of prostate-specific membrane antigen-based radioligand therapy (RLT) for metastatic prostate cancer in a patient with autosomal-dominant polycystic kidney disease. Methods: The received hemodialysis during each 6 RLT cycles while staying as an inpatient. used voxel dosimetry and blood sampling dose calculation. Results: responded well to RLT, indicated by antigen level decreasing from 298 7.1 ng/mL. doses per cycle ranged 0.19 0.4 Gy/GBq parotid gland,...