A5039397033- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Developmental Biology and Gene Regulation
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Zebrafish Biomedical Research Applications
- NMR spectroscopy and applications
- Congenital heart defects research
- Photoacoustic and Ultrasonic Imaging
- Medical Imaging Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- MRI in cancer diagnosis
- Electron Spin Resonance Studies
- Hemispheric Asymmetry in Neuroscience
- Retinal Development and Disorders
- Shoulder Injury and Treatment
- Advanced NMR Techniques and Applications
- Ultrasound Imaging and Elastography
- Metabolism and Genetic Disorders
- Animal Genetics and Reproduction
- Osteoarthritis Treatment and Mechanisms
- Axon Guidance and Neuronal Signaling
- Ultrasound and Hyperthermia Applications
- Wnt/β-catenin signaling in development and cancer
University of California, San Diego
2010-2024
University of Trento
2018-2024
General Electric (United States)
2018-2024
American Society for Surgery of the Hand
2023
GE Global Research (United States)
2020-2021
Heidelberg University
2009-2020
University Hospital Heidelberg
2011-2020
University Medical Centre Mannheim
2012-2020
Resonance Research (United States)
2018-2019
Mayo Clinic
2018-2019
Background: In Germany, more than 100,000 patients are monitored and treated in 80 intensive care units (ICUs) following cardiac surgery each year. The controversies concerning the different methods of hemodynamic monitoring appropriate agents for volume therapy inotropic support well known. However, little is known about how treatment currently performed. Methods: A questionnaire with 39 questions was sent to leading physicians ICUs treating after surgery. be answered covered current...
Left-right asymmetries are most likely a universal feature of bilaterian nervous systems and may serve to increase neural capacity by specializing equivalent structures on left right sides for distinct roles [1Concha M.L. Bianco I.H. Wilson S.W. Encoding asymmetry within circuits.Nat. Rev. Neurosci. 2012; 13: 832-843Crossref PubMed Scopus (95) Google Scholar]. However, little is known about how encoded vertebrate circuits lateralization influences processing information in the brain....
The resistance to coronary blood flow in various parts of the myocardium was studied with tracer microspheres technique before and immediately after an acute occlusion several weeks a more slowly occurring by Ameroid constrictor. All experiments were carried out isolated, metabolically supported, empty, beating dog heart at maximal vasodilation induced adenosine. Coronary normal empty 0.20 mm Hg/(ml/min) per 100 g tissue (subepicardium) 0.16 (subendocardium). After perfusion subtended...
Abstract Biological tissues frequently contain different water compartments, and these often have distinct transverse relaxation times. Quantification of may be problematic on clinical scanners because spin echo sequences usually initial times that are too long to accurately quantify shorter time components. In this study, an ultrashort pulse sequence was used together with bicomponent analysis both the short T 2 components in musculoskeletal system. Feasibility studies were performed using...
Purpose The long repetition time and inversion with recovery preparation ultrashort echo (UTE) often causes prohibitively scan times. We present an optimized method for T2 signal suppression in which several k-space spokes are acquired after each preparation. Theory Methods Using Bloch equations the sequence parameters such as TI flip angle were to suppress water fat signals maximize short contrast. Volunteer imaging was performed on a healthy male volunteer. Inversion using Silver-Hoult...
The establishment of retinal identity and the subsequent patterning optic vesicle are key steps in early vertebrate eye development. To date little is known about nature interaction genes controlling these steps. So far few have been identified that, when over-expressed, can initiate ectopic formation. Of note Six3, which expressed exclusively anterior neural plate. However, 'loss function' analysis has not reported. Using medaka fish, we show that Six3 necessary for neuroectoderm including...
The complete absence of eyes in the medaka fish mutation eyeless is result defective optic vesicle evagination. We show that caused by an intronic insertion Rx3 homeobox gene resulting a transcriptional repression locus rescued injection plasmid DNA containing wild-type locus. Functional analysis reveals Six3- and Pax6- dependent retina determination does not require Rx3. However, gain- loss-of-function phenotypes indispensable to initiate evagination control proliferation, regulating organ...
In this study, we report the use of a novel ultrashort echo time T(1)rhoT(1) sequence that combines spin-lock preparation pulse with two-dimensional nominal 8 microsec. The time-T(1)rho was employed to quantify T(1)rho in short T(2) tissues including Achilles tendon and meniscus. dispersion investigated by varying field strength. Preliminary results on six cadaveric ankle specimens five healthy volunteers show provides high signal contrast for both mean ranged from 3.06 +/- 0.51 msec 5.22...
Hemodynamic monitoring and adequate volume-therapy, as well the treatment with positive inotropic drugs vasopressors are basic principles of postoperative intensive care patient after cardiothoracic surgery. The goal these S3 guidelines is to evaluate recommendations in regard evidence based medicine define therapy goals for therapy. In context clinical situation evaluation different hemodynamic parameters allows development a therapeutic concept definition criteria effect treatment. Up now...
To accelerate the quantitative ultrashort echo time imaging using a time-efficient 3D multispoke Cones sequence with magnetization transfer (3D UTE-Cones-MT) and signal modeling.A UTE-Cones-MT acquisition scheme per MT preparation modified rectangular pulse (RP) approximation was developed for two-pool modeling of macromolecular water components including their relative fractions, relaxation times exchange rates. Numerical simulation cadaveric specimens, human Achilles tendon bovine cortical...
To develop an accurate T1 measurement method for short T2 tissues using a combination of 3-dimensional ultrashort echo time cones actual flip angle imaging technique and variable repetition (3D UTE-Cones AFI-VTR) on clinical 3T scanner.First, the longitudinal magnetization mapping function excitation pulse was obtained with 3D AFI method, which provided information about efficiency B1 inhomogeneity. Then, derived substituted into VTR fitting to generate maps. Numerical simulation phantom...
Purpose To investigate high contrast imaging of short T 2 tissues with a three‐dimensional double adiabatic inversion recovery prepared ultrashort echo time Cones (3D DIR‐UTE‐Cones) sequence. Methods The sequence used two sequential pulses to suppress signals from long tissues, followed by multispoke UTE acquisition detect tissues. are identical center frequency located at the water peak, but spectral width is broad enough cover both and fat frequencies. feasibility this technique was...
Purpose To develop a 3D adiabatic T 1ρ prepared ultrashort echo time cones (3D AdiabT UTE‐Cones) sequence for whole knee imaging on clinical 3T scanner. Methods A train of full passage pulses were used spin locking, followed by time‐efficient multispoke UTE acquisition to detect signals from both short and long 2 tissues in the joint. modified signal model was proposed data fitting. The feasibility this UTE‐Cones technique demonstrated through numerical simulation, phantom, ex vivo sample...
Nodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided signaling epithalamic region of zebrafish forebrain. Epithalamic subsequently determines laterality neuroanatomical asymmetries. We show that overactivation Wnt/Axin1/beta-catenin during late gastrulation leads bilateral expression pathway genes independently LPM signaling. This consistent with a model whereby normally bilaterally repressed, from unilaterally alleviating repression. suggest Wnt...
Functional lateralization is a conserved feature of the central nervous system (CNS). However, underlying left-right asymmetries within neural circuitry and mechanisms by which they develop are poorly described.In this study, we use focal electroporation to examine morphology connectivity individual neurons lateralized habenular nuclei. Habenular projection on both sides brain share stereotypical unipolar elaborate remarkable spiraling terminal arbors in their target interpeduncular nucleus,...
Although it is well established that Six3 a crucial regulator of vertebrate eye and forebrain development, unknown whether this homeodomain protein has role in the initial specification anterior neural plate. In study, we show exogenous can expand plate both Xenopus zebrafish, occurs part through Six3-dependent transcriptional regulation cell cycle regulators cyclinD1 p27Xic1, as anti-neurogenic genes Zic2 Xhairy2. However, still presence inhibitors likely to be due its ability repress...