A5083642413- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Acute Myeloid Leukemia Research
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Lignin and Wood Chemistry
- Radiopharmaceutical Chemistry and Applications
- Mechanical Circulatory Support Devices
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Retinoids in leukemia and cellular processes
- Hematopoietic Stem Cell Transplantation
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Cardiac Structural Anomalies and Repair
- Management of metastatic bone disease
- Radiation Dose and Imaging
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
University Hospital of Zurich
2020-2025
University of Zurich
2020-2025
University of Cologne
2024
University Hospital of Bern
2024
University of Bern
2024
Asklepios Klinik Sankt Augustin
2024
Intertek (Sweden)
2022
Medical University of Vienna
2020-2022
Ludwig Boltzmann Institute for Cancer Research
2020-2022
Ludwig Boltzmann Institute for Digital Health and Prevention
2020-2022
Abstract Purpose Improved logistics and availability led to a rapid increase in the use of [ 18 F]-PSMA-1007 for prostate cancer PET imaging. Initial data suggests increased uptake benign lesions compared 68 Ga]-PSMA-11, clinical observations found unspecific bone (UBU). We therefore investigate frequency characteristics UBU PET. Methods retrospectively analyzed scans from four centers presence UBU, defined as focal mild-to-moderate (SUV max < 10.0) not obviously related or malignant...
Altered histone deacetylase (HDAC) activity has been identified in several types of cancer. This study was designed to determine the safety and maximum tolerated dose (MTD) valproic acid (VPA) as an HDAC inhibitor cancer patients. Twenty-six pre-treated patients with progressing solid tumours were enrolled dose-escalating three-patient cohorts, starting at a VPA 30 mg kg−1 day−1. administered 1-h infusion daily for 5 consecutive days 21-day cycle. Neurocognitive impairment dominated toxicity...
To assess the frequency, intensity, and clinical impact of [18F]FDG-avidity axillary lymph nodes after vaccination with COVID-19 vaccines BNT162b2 (Pfizer-BioNTech) mRNA-1273 (Moderna) in patients referred for oncological FDG PET/CT.One hundred forty PET/CT during February March 2021 first or second Pfizer-BioNTech Moderna were retrospectively included. FDG-avidity ipsilateral was measured compared. Assuming no knowledge prior vaccination, metastatic risk analyzed by two readers...
ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). It consists of an N-terminal single-chain fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA). Potent antitumoral activity scFv(FRP5)-ETA against ErbB2-overexpressing tumor cells was previously demonstrated in vitro and animal models. Here we report the first systemic application human cancer patients. We have performed phase I dose-finding study, objective assess maximum...
Abstract The use of left ventricular assist devices (LVADs) as a treatment method for heart failure patients has been steadily increasing; however, pathological studies showed presence thrombi around the HeartWare device inflow cannula (IC) in more than 95% after explantation. Flow fields IC might trigger thrombus formation and require further investigation. In this study flow dynamics parameters were evaluated different patient geometries using computational fluid (CFD) simulations. Left...
Abstract Purpose Recently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane antigen (PSMA) uptake [ 68 Ga]PSMA-PET. It is the aim this study to evaluate these ADC (mm 2 /1000 s) values in comparison Ga]PSMA PET/MRI. Methods We retrospectively evaluated patients who underwent PET/MRI for staging or biopsy guidance, followed by radical prostatectomy at our institution 07/2016 01/2020. The dominant lesion...
In acute myeloid leukemias (AMLs) with t(8;21), the transcription factor AML1 is juxtaposed to zinc finger nuclear protein ETO (Eight-Twenty-One), resulting in transcriptional repression of target genes. has been shown interact corepressors, such as N-CoR and mSin3A form complexes containing histone deacetylases. To define regions required for maximal repressor activity, we analyzed amino-terminal deletions a assay. We found that mutants lacking first 236 amino acids were not affected their...
Objectives The aim of this study was to compare the accuracy photon-counting detector computed tomography (PCD-CT) iodine maps lung parenchyma with perfusion scintigraphy for detection and extent estimation pulmonary defects. Materials Methods This institutional review board–approved retrospective included 26 subjects (11 male, aged 57.2 ± 15.8 years; 15 female, 55.2 15.7 years) who underwent clinically indicated PCD-CT SPECT/CT assess chronic thromboembolic hypertension (CTEPH). Two blinded...
Based on video analysis of downhill skiing areas a model for ski traffic is developed. The uses PeTrack to determine the trajectories individual skiers which are then statistically analysed. A stochastic cellular automaton proposed that can reproduce basic observed features. empirical data used validation and calibration model. In future, may help analyse comfort safety slopes, especially risk collisions.
To assess the accuracy of fully automated deep learning (DL) based coronary artery calcium scoring (CACS) from non-contrast computed tomography (CT) as acquired for attenuation correction (AC) cardiac single-photon-emission myocardial perfusion imaging (SPECT-MPI). Patients were enrolled in this study part a larger prospective (NCT03637231). In study, 56 who underwent SPECT-MPI due to suspected disease (CAD) prospectively enrolled. All patients CT AC twice. CACS was manually assessed...
Background: Investigation of the clinical feasibility dynamic whole-body (WB) [18F]FDG PET, including standardized uptake value (SUV), rate irreversible (Ki), and apparent distribution volume (Vd) in physiologic tissues, comparison between inflammatory/infectious cancer lesions. Methods: Twenty-four patients were prospectively included to undergo WB PET/CT for clinically indicated re-/staging oncological diseases. Parametric maps Ki Vd generated using Patlak analysis alongside SUV images....
Abstract Purpose Prostate-specific membrane antigen (PSMA)-targeted PET is increasingly used for staging prostate cancer (PCa) with high accuracy to detect significant PCa (sigPCa). [ 68 Ga]PSMA-11 PET/MRI-guided biopsy showed promising results but also persisting limitation of sampling error, due impaired image fusion. We aimed assess the possibility intraoperative quantification 18 F]PSMA-1007 PET/CT uptake in core biopsies as an instant confirmation accurate lesion sampling. Methods In...
Objectives: To evaluate the impact of fully automatic motion correction by data-driven respiratory gating (DDG) on positron emission tomography (PET) image quality, lesion detection and patient management. Materials Methods: A total 149 patients undergoing PET/CT for cancer (re-)staging were retrospectively included. Patients underwent a digital detector scanner every PET data set where DDG was enabled (PETDDG) as well not (PETnonDDG) reconstructed. All sets evaluated two readers which rated...
PSMA PET/MRI showed the potential to increase sensitivity for extraprostatic disease (EPD) assessment over mpMRI; however, interreader variability EPD is still high. Therefore, we aimed assess whether quantitative and mpMRI imaging parameters could yield a more robust prediction.We retrospectively evaluated PCa patients who underwent staging [68Ga]PSMA-PET, followed by radical prostatectomy at our institution between 01.02.2016 31.07.2019. Fifty-eight cases with 15 PET/CT were identified....
To compare block sequential regularized expectation maximization (BSREM) and ordered subset (OSEM) for the detection of in-transit metastasis (ITM) malignant melanoma in digital [18F]FDG PET/CT.We retrospectively analyzed a cohort 100 PET/CT scans patients with ITM, performed between May 2017 January 2020. PET images were reconstructed both OSEM BSREM algorithms. SUVmax, target-to-background ratio (TBR), metabolic tumor volume (MTV) recorded each ITM. Differences parameters Wilcoxon...
Abstract The aim of the study was to analyze use block sequential regularized expectation maximization (BSREM) with different β -values for detection brain metastases in digital fluorine-18 labeled 2-deoxy-2-fluoro-D-glucose (18F-FDG) PET/CT lung cancer patients. We retrospectively analyzed staging/restaging 18F-FDG scans 40 consecutive patients new metastases, confirmed by MRI. PET images were reconstructed using BSREM ( 100, 200, 300, 400, 500, 600, 700) and OSEM. Two independent blinded...
The aim of this study was to assess the relationship between histopathological properties hyperfunctioning parathyroids and parathyroid 18F-choline uptake.A total 31 adenomas were retrospectively analyzed in patients with primary hyperparathyroidism preoperative PET/MR. PET/MR parameters glands (SUVmax target-to-background ratio early-phase [EP] late-phase [LP]), MRI volume, hormone (PTH) serum concentration, postoperative histopathology (predominant cell type growth pattern adenoma cells,...