Isabelle Opitz
A5087464605- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hedgehog Signaling Pathway Studies
- Pulmonary Hypertension Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Radiation Dose and Imaging
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Chromatin Remodeling and Cancer
- Renal Transplantation Outcomes and Treatments
- Oral and Maxillofacial Pathology
- Cardiac, Anesthesia and Surgical Outcomes
University Hospital of Zurich
2016-2025
University of Zurich
2016-2025
Spital Uster
2024
St James's University Hospital
2022
Thorax Foundation
2022
Chungbuk National University Hospital
2021
Kantonsspital St. Gallen
2021
University Hospital of Geneva
2021
Society of Thoracic Surgeons
2018
Thoracic Surgery Foundation
2011-2017
Background: Radiomics is a promising methodology for quantitative analysis and description of radiological images using advanced mathematics statistics. Tumor delineation, which still often done manually, an essential step in radiomics, however, inter-observer variability well-known uncertainty radiation oncology. This study investigated the impact (IOV) manual tumor delineation on reliability radiomic features (RF).Methods: Three different types (head neck squamous cell carcinoma (HNSCC),...
Abstract The European Respiratory Society (ERS)/European of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after systematic review the 2009–2018 literature. evidence was appraised using Grading Recommendations, Assessment, Development...
The International Association for the Study of Lung Cancer collaborated with Mesothelioma Interest Group to propose first TNM stage classification system diffuse pleural mesothelioma in 1995, accepted by Union Control and American Joint Committee on sixth seventh edition manuals. Staging Prognostic Factors Domain developed analyzed an international registry patients updated descriptors eighth system. To inform revisions forthcoming ninth system, data submission was solicited diagnosed...
The purpose of our study was to assess robustness volumetric measurement malignant pleural mesothelioma (MPM) before and after chemotherapy modified RECIST (response evaluation criteria in solid tumours) criteria. 30 patients with digitally available chest computed tomography (CT) scans three cycles were included. Three readers independently assessed tumour response using two different methods: 1) the criteria; 2) approach dedicated software (Myrian; Intrasense, Paris, France). Inter-rater...
Malignant pleural mesothelioma (MPM) is an aggressive cancer with short overall survival. Long non-coding RNAs (lncRNA) are a class of more than 200 nucleotides long that do not code for protein and part the 90% human genome transcribed. Earlier experimental studies in mice showed GAS5 (growth arrest specific transcript 5) gene deletion asbestos driven mesothelioma. encodes lncRNA whose function well known, but it has been shown to act as glucocorticoid receptor decoy microRNA "sponge". Our...
We recently discovered an inherited cancer syndrome caused by BRCA1-Associated Protein 1 (BAP1) germline mutations, with high incidence of mesothelioma, uveal melanoma and other cancers very penetrance age 55. To identify families the BAP1 syndrome, we screened patients family histories multiple mesotheliomas melanomas and/or cancers. identified four that shared identical mutation: they lived across US did not appear to be related. By combining histories, molecular genetics, genealogical...