A5005951305- Breast Cancer Treatment Studies
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Cancer-related cognitive impairment studies
- Palliative Care and End-of-Life Issues
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Family Support in Illness
- Colorectal Cancer Treatments and Studies
- Breast Implant and Reconstruction
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Family and Patient Care in Intensive Care Units
- Brain Metastases and Treatment
- Patient-Provider Communication in Healthcare
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Lymphatic System and Diseases
- COVID-19 and healthcare impacts
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
International Breast Cancer Study Group
2016-2025
Kalaidos University of Applied Sciences
2023-2025
University of Lausanne
2018-2024
Swiss Group For Clinical Cancer Research
2007-2022
Institute for Work and Health
2018-2021
Solothurner Spitäler
2021
HES-SO University of Applied Sciences and Arts Western Switzerland
2021
Kantonsspital Graubünden
2021
Kantonsspital Aarau
2021
University of Bern
2021
Adjuvant therapy with an aromatase inhibitor improves outcomes, as compared tamoxifen, in postmenopausal women hormone-receptor-positive breast cancer.In two phase 3 trials, we randomly assigned premenopausal early cancer to the exemestane plus ovarian suppression or tamoxifen for a period of 5 years. Suppression estrogen production was achieved use gonadotropin-releasing-hormone agonist triptorelin, oophorectomy, irradiation. The primary analysis combined data from 4690 patients...
Prospective data on the risk of recurrence among women with hormone receptor–positive early breast cancer who temporarily discontinue endocrine therapy to attempt pregnancy are lacking. Download a PDF Research Summary. We conducted single-group trial in which we evaluated temporary interruption adjuvant young previous cancer. Eligible were 42 years age or younger; had stage I, II, III disease; received for 18 30 months; and desired pregnancy. The primary end point was number events (defined...
Background: Previous studies consistently found remarkable prevalence rates of posttraumatic stress symptoms (PTSS) and disorders (PTSD) in pediatric patients their parents. Findings suggest a significant association between child parent PTSS. The present study examined, sample with different conditions, incidence determinants PTSS PTSD the patients, mothers fathers. Also, associations maternal, paternal were analyzed. Method: Two hundred nine children (aged 6.5–14.5 years) interviewed 5–6...
Childhood craniopharyngiomas are histologically benign tumours arising from remnants of Rathke's pouch in the hypothalamic-pituitary region. The two common treatment approaches primary total resection or limited followed by radiotherapy. To study outcome after a surgical approach, we 25 consecutive patients (10 females, 15 males) under 16 years age who were treated single institution with management policy radical tumour excision (mean at diagnosis 9 2 months, SD 4 3 months; range months to...
Childhood craniopharyngiomas are histologically benign tumours arising from remnants of Rathke's pouch in the hypothalamic—pituitary region. The two common treatment approaches primary total resection or limited followed by radiotherapy. To study outcome after a surgical approach, we 25 consecutive patients (10 females, 15 males) under 16 years age who were treated single institution with management policy radical tumour excision (mean at diagnosis 9 2 months, SD 4 3 months; range months to...
To investigate how involvement preferences of patients with breast cancer change during the treatment decision-making process and determine impact meeting patients' expectations on outcomes.Participants were 683 from 62 oncologists in five different countries recruited to an International Breast Cancer Study Group (IBCSG 33-03) project. Questionnaires elicited pre- postconsultation for decision making whether these met or not. Decision-related outcomes assessed postconsultation.Before...
Purpose To describe benefits and toxicities of adjuvant endocrine therapies in women younger than 35 years with breast cancer (n = 582) enrolled the Suppression Ovarian Function Trial (SOFT) Tamoxifen Exemestane (TEXT). Methods In SOFT, still premenopausal after surgery or without chemotherapy were randomly assigned to tamoxifen alone, plus ovarian function suppression (OFS), exemestane OFS. TEXT, all received OFS concomitant We summarize treatment efficacy, quality life, adherence cohort...
The Suppression of Ovarian Function trial showed improved disease control for tamoxifen plus ovarian function suppression (OFS) compared with alone the cohort premenopausal patients who received prior chemotherapy. We present patient-reported outcomes.The quality-of-life (QoL) analysis includes 1,722 2,045 hormone receptor-positive breast cancer randomly assigned to receive adjuvant treatment 5 years OFS or alone. Chemotherapy use before enrollment was optional. Patients completed a QoL form...
Complete lymph node removal through conventional axillary dissection (ALND) has been standard treatment for breast cancer patients almost a century. In the 1990s, however, and in parallel with advent of sentinel (SLN) procedure, ALND came under increasing scrutiny due to its association significant patient morbidity. Several studies have since provided evidence suggest omission ALND, often favor radiation, selected clinically node-negative, SLN-positive patients, thus supporting current...
To study the outcomes in long-term survivors of paediatric medulloblastoma (MB), we followed 51 consecutive children who were treated between 1980 and 2000 a single institution. In 18 26 (mean follow-up time 12.2 years), tumour control, neurological, endocrine, neurocognitive complications their impact on behavioural psychological adjustment, health-related quality life (QoL) comprehensively assessed using qualitative quantitative measures. Endocrine deficits occurred 61 %, neurological 72...
To determine rates of posttraumatic stress disorder (PTSD) and symptoms in mothers fathers children with newly diagnosed type 1 diabetes.Parents 38 diabetes were assessed the Posttraumatic Diagnostic Scale 6 weeks after diagnosis.Twenty-four percent 22% met full diagnostic criteria for current PTSD. In addition, 51% 41% partial or subclinical Co-occurence PTSD couples was very low. symptomatology did not correlate age gender child, socioeconomic status, family structure, length hospital...
Cognitive function in postmenopausal women receiving letrozole or tamoxifen as adjuvant endocrine treatment was compared during the fifth year of a substudy BIG 1-98 trial. In patients were randomized to receive (A) 5-years tamoxifen, (B) letrozole, (C) 2-years followed by 3-years (D) tamoxifen. The primary comparison difference composite score for taking (B+C; N=65) vs. (A+D; N=55). had better overall cognitive than those (difference mean z-scores=0.28, P=0.04, 95% CI: 0.02, 0.54, Cohen's...
Objective: To compare, in a phase 3, prospective, randomized, multi-center clinical trial functional outcome of reconstruction procedures following total mesorectal excision (TME). Summary Background Data: Intestinal continuity TME is accompanied by postoperative defecation dysfunctions known as “anterior resection syndrome.” Commonly used techniques are straight colorectal anastomosis (SCA), colon J -pouch (CJP), and side-to-end (SEA). Comparison their outcomes studies, including long-term...
Abstract Purpose Studies focusing on patients with and survivors of cancer during the COVID-19 pandemic highlight unique psychological behavioral challenges. These findings were obtained in surveys using self-report questionnaires pre-specified response options that may not capture broad range experiences individuals affected by cancer, including people informal caregivers, this unprecedented situation. Online forums produce a large amount valuable first-hand user-generated content can be...