Samuele Massarut
A5070502173- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced Radiotherapy Techniques
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Advances in Oncology and Radiotherapy
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Reconstructive Surgery and Microvascular Techniques
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Clinical practice guidelines implementation
- Wound Healing and Treatments
- Nutritional Studies and Diet
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
Centro di Riferimento Oncologico
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2025
University College London
2009-2024
Antwerp University Hospital
2022
Marienhospital Bottrop
2019
Charité - Universitätsmedizin Berlin
2019
Breast Center
2011-2018
International Breast Cancer Study Group
2011-2018
Città di Castello Hospital
2015
National Cancer Institute
2012
Case reports have been a long held tradition within the surgical literature. Reporting guidelines can improve transparency and reporting quality. However, recent consensus-based for case (CARE) are not surgically focused. Our objective was to develop report guidelines.The CARE statement used as basis Delphi consensus. The questionnaire administered via Google Forms conducted using standard methodology. A multidisciplinary group of surgeons others with expertise in were invited participate....
Case series have been a long held tradition within the surgical literature and are still frequently published. Reporting guidelines can improve transparency reporting quality. No guideline exists for case series, our recent systematic review highlights fact that key data being missed from such reports. Our objective was to develop series.A Delphi consensus exercise conducted determine items include in guideline. Items included those identified previous on SCARE Guidelines The questionnaire...
Abstract Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early cancer. Design Prospective, open label, randomised controlled clinical trial. Setting 32 centres in 10 countries the United Kingdom, Europe, Australia, States, and Canada. Participants 2298 women aged 45 years older with invasive ductal carcinoma up to 3.5 cm size, cN0-N1,...
After apparently successful excision of breast cancer, risk local recurrence remains high mainly in the area surrounding original tumor, indicating that wound healing processes may be implicated. The proportional reduction this by radiotherapy does not depend on extent surgery, suggesting radiotherapy, addition to killing tumor cells, influence microenvironment.We studied how normal and mammary carcinoma cell growth motility are affected surgical fluids (WF), collected over 24 h following...
As evidence questioning the rationale behind neoadjuvant chemotherapy in breast cancer grows, Jayant Vaidya and colleagues say we must reconsider current treatment options
<h3>Importance</h3> Conventional adjuvant radiotherapy for breast cancer given daily several weeks is onerous and expensive. Some patients may be obliged to choose a mastectomy instead, some forgo altogether. We proposed clinical trial test whether could safely limited the tumor bed. <h3>Objective</h3> To determine delayed second-procedure targeted intraoperative (TARGIT-IORT) noninferior whole-breast external beam (EBRT) in terms of local control. <h3>Design, Setting, Participants</h3> In...
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes HRQoL after a 12-month lifestyle modification program 227 BC survivors participating DEDiCa trial (Mediterranean diet, exercise, vitamin D). was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 EORTC QLQ-BR23. Baseline were tested using analysis variance. Multiple regression analyses performed...
<h3>Objective</h3> To quantify the journeys and CO<sub>2</sub> emissions if women with breast cancer are treated risk-adapted single-dose targeted intraoperative radiotherapy (TARGIT) rather than several weeks9 course of external beam whole (EBRT) treatment. <h3>Setting</h3> (1) TARGIT-A randomised clinical trial (ISRCTN34086741) which compared TARGIT traditional EBRT found similar control, particularly when was given simultaneously lumpectomy, (2) 2 additional UK centres offering TARGIT....
Locally advanced HER2-overexpressing breast cancer (BC) patients achieve a high rate of pathological complete responses (pCR) after neoadjuvant chemotherapy (NC). The apparently unaltered immune proficiency these together with the immune-modulating activities NC drugs suggest potential contribution host immunity in mediating clinical responses. We thus performed an extensive immunomonitoring locally BC undergoing to identify immunological correlates pCR induction.The profile 40 HER2-positive...
miR-223 is an anti-inflammatory miRNA that in cancer acts either as oncosuppressor or oncopromoter, a context-dependent manner. In breast cancer, we demonstrated it dampens the activation of EGF pathway. However, little known on role during onset and progression. expression was decreased luminal HER2 subtypes inversely correlated with patients' prognosis. normal mammary epithelial cells, acted cell autonomously control their growth morphology three-dimensional context. MMTV-Δ16HER2...
Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality life (HRQoL) in healthy subjects. HRQoL is relevant cancer therapy and disease outcomes, therefore we investigated association between adherence to MedDiet breast survivors participating multicentre trial DEDiCa. were assessed at baseline subgroup 309 women enrolled within 12 months diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire...
Abstract The extracellular matrix (ECM) is an important component of the tumor microenvironment and undergoes extensive remodeling during both initiation progression breast cancer (BC). EMILIN1 ECM glycoprotein, whose function has been linked to metastasis. However, role mammary gland BC development never investigated. In silico molecular analyses human samples from normal showed that expression was lower in tumors than healthy tissue it predicted poor prognosis, particularly HER2-positive...