A5004341642- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Breast Lesions and Carcinomas
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Microwave Imaging and Scattering Analysis
- Breast Implant and Reconstruction
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Ultrasonics and Acoustic Wave Propagation
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Radiopharmaceutical Chemistry and Applications
- AI in cancer detection
- Bladder and Urothelial Cancer Treatments
- MRI in cancer diagnosis
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Pediatric Urology and Nephrology Studies
- Ultrasound Imaging and Elastography
- Xenotransplantation and immune response
European Institute of Oncology
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2008-2023
Ripamonti
2006-2020
Policlinico San Matteo Fondazione
2020
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2019
University of Milan
2001-2018
Mylan (Switzerland)
2015
Ente Ospedaliero Ospedali Galliera
2008
Carlo Forlanini Hospital
1999
Ospedale San Carlo
1999
Although numerous studies have shown that the status of sentinel node is an accurate predictor axillary nodes in breast cancer, efficacy and safety sentinel-node biopsy require validation.From March 1998 to December 1999, we randomly assigned 516 patients with primary cancer whom tumor was less than or equal 2 cm diameter either total dissection (the axillary-dissection group) followed by only if contained metastases group).The number found same two groups. A positive 83 257 group (32.3...
Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although pathways of tumour cell dissemination are unclear. Here we show that chronic restructures lymphatic networks within around tumours to provide for escape. We VEGFC derived cells is required induce remodelling this depends on COX2 inflammatory macrophages. Pharmacological inhibition SNS blocks effect in vivo reduces metastasis preclinical models patients with breast cancer. These...
Knowledge of the dielectric properties human tissues is important for several biomedical applications, including imaging and hyperthermia treatment, as well determining safety thresholds in policy making. Breast tissues, both normal tumorous, are particular interest because medical social impact breast cancers. While experimental data available up to 20 GHz, higher frequencies, this information missing, or has been extrapolated from models based on lower-frequency data. Emerging technologies...
Abstract Purpose: The purpose of this research was to identify factors predicting response preoperative chemotherapy. Experimental Design: In a large volume laboratory using standard immunohistochemical methods, we reviewed the pretreatment biopsies and histologic specimens at final surgery 399 patients with or locally advanced breast cancer (cT2-T4, N0–2, M0) who were treated incidence pathological complete remission node-negative status assessed respect initial clinical findings....
BACKGROUND Sentinel lymph node (SLN) biopsy is used increasingly in patients with clinically negative, early-stage breast carcinoma, because it can spare axillary dissection when the sentinel nodes are negative. The question arises, however, whether complete (ALND) also necessary only micrometastases (≤ 2 mm greatest dimension) SLNs. authors carried out current study to ascertain risk of non-SLN metastases such and assess detection rate SLN relation sectioning interval number sections...
Abstract BACKGROUND Aging remains one of the single greatest risk factors for development new breast carcinoma. The aim study was to evaluate relation between biologic features at first diagnosis carcinoma and treatment choice postmenopausal women ≥ 50 years optimize in elderly. METHODS sample included 2999 consecutive patients referred surgery European Institute Oncology (Milan, Italy) from April 1997 February 2002. were grouped according age: young (YPM; 50–64 years, n = 2052), older (OPM;...
Medical imaging currently relies on several techniques, including X-rays, magnetic resonance, and echography. However, these techniques exhibit drawbacks, alternative approaches are required. Microwave has been proposed as a possible solution, especially for breast cancer imaging. most of systems work with central frequency few gigahertz, this leads to suboptimum resolution, which can jeopardize the image quality. Millimeter waves provide superior resolutions, at cost lower penetration depth...
Mastectomy with axillary dissection is still the most commonly recommended procedure for male breast cancer. The aim of this study was to retrospectively evaluate our experience in 32 patients early cancer who underwent sentinel lymph node biopsy (SLNB) and only cases metastases (SLN). median age 58 years (range, 33-80). Lymphoscintigraphy successful all patients, a mean number visualized SLNs per patient 1.3 1-2). At surgery, identification rate SLN 100%, removed 1.5 1-3). Twenty-six had...
<h2>Abstract</h2> Percutaneous core biopsy (CB) has been introduced to increase the ability of accurately diagnosing breast malignancies without need resorting surgery. Compared conventional automated 14 gauge needle (NCB), vacuum-assisted (VANCB) allows obtaining larger specimens and recognized advantages particularly when radiological pattern is represented by microcalcifications. Regardless technical improvements, a small percentage percutaneous CBs performed detect lesions are still...
Background. Breast cancer during pregnancy (BCP) is relatively rare and associated with controversies about its biology prognosis. Hence, we designed a case-control study to examine tumor features outcome in series of BCP patients diagnosed treated single institution. Material methods. We identified 65 for each; selected two non-pregnant breast patients, who were matched age, year surgery, stage, neoadjuvant chemotherapy. then compared the differences pathology, immunohistochemical (ER, PR,...
Background. In patients with metastatic breast cancer, the evaluation of biological characteristics bone deposits may be a valuable adjunct in clinical practice. We assessed discordance expression levels for estrogen receptor (ER), progesterone (PgR) and human epidermal growth factor 2 (HER2) between primary tumor metastases its impact on patient management. Material methods. retrospectively reviewed 363 CT-guided biopsies performed from January 1997 to December 2009. The proportions ER, PgR...
To ascertain the prognostic relevance of micropapillary carcinoma, a specific type breast tumour.We interrogated clinical records series 49 pure carcinoma patients and 13 487 invasive ductal patients, diagnosed treated consecutively in our institution over 9-year time-frame. Compared with more frequently had moderately differentiated tumours (P = 0.02) extensive peritumoral vascular invasion < 0.0001), associated significantly higher rate axillary lymph node involvement 0.0001). Survival...
To investigate whether use of multiparametric magnetic resonance (MR) imaging-directed intraoperative frozen-section (IFS) analysis during nerve-sparing robot-assisted radical prostatectomy reduces the rate positive surgical margins.This retrospective prospectively acquired data was approved by an institutional ethics committee, and requirement for informed consent waived. Data were reviewed 134 patients who underwent preoperative MR imaging (T2 weighted, diffusion dynamic contrast-material...
Most patients who initially respond to treatment with the multi-tyrosine kinase inhibitor sunitinib eventually relapse. Therefore, developing a deeper understanding of contribution sunitinib's numerous targets clinical response or resistance is crucial. Here, we have shown that cancer cells clinically relevant doses by enhancing stability antiapoptotic protein MCL-1 and inducing mTORC1 signaling, thus evoking little cytotoxicity. Inhibition signaling sensitized in vitro was synergistic...