A5015077519- Cutaneous Melanoma Detection and Management
- Vitamin D Research Studies
- Skin Protection and Aging
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- melanin and skin pigmentation
- Head and Neck Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Metabolism, Diabetes, and Cancer
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- BRCA gene mutations in cancer
- COVID-19 Clinical Research Studies
- Nonmelanoma Skin Cancer Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Breast Lesions and Carcinomas
- Vitamin C and Antioxidants Research
European Institute of Oncology
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
University of Milan
1990-2023
Ripamonti
2014-2023
Institutul Oncologic Bucuresti
2022
IRCCS Humanitas Research Hospital
2021
Molecular Oncology (United States)
2020
Cancer Research And Biostatistics
1998-2018
Jessa Hospital
2018
Klinikum rechts der Isar
2018
Clinical responses to ipilimumab are variable in terms of onset, magnitude and duration. Upfront identification patients who more likely or unlikely benefit from treatment is a major need.Prospectively collected data 720 advanced melanoma treated with 3 mg/kg within the Italian expanded access program were analyzed. The derived neutrophil-to-lymphocyte ratio (dNLR) was calculated baseline peripheral blood cell counts, receiver operating characteristic curve used evaluate best cutoff for this...
Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although pathways of tumour cell dissemination are unclear. Here we show that chronic restructures lymphatic networks within around tumours to provide for escape. We VEGFC derived cells is required induce remodelling this depends on COX2 inflammatory macrophages. Pharmacological inhibition SNS blocks effect in vivo reduces metastasis preclinical models patients with breast cancer. These...
Abstract Excessive activation of blood coagulation and neutrophil accumulation have been described in several human cancers. However, whether hypercoagulation neutrophilia are linked involved cancer development is currently unknown. Here we show that spontaneous intestinal tumorigenesis correlates with the low-density neutrophils a pro-tumorigenic N2 phenotype unprompted extracellular traps (NET) formation. We find increased circulating lipopolysaccharide induces upregulation complement C3a...