Manimozhiyan Arumugam
A5058914957- Gut microbiota and health
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Diabetes Management and Education
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Bioinformatics and Genomic Networks
- Dietary Effects on Health
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- Microbial Community Ecology and Physiology
- Gastrointestinal motility and disorders
- Digestive system and related health
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Scientific Computing and Data Management
- Molecular Biology Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Viral gastroenteritis research and epidemiology
- Pharmaceutical and Antibiotic Environmental Impacts
Novo Nordisk Foundation
2015-2024
University of Copenhagen
2015-2024
University of Southern Denmark
2019-2024
Odense University Hospital
2019-2023
Novo Nordisk (Denmark)
2023
Maersk (Denmark)
2013-2021
Max Planck Institute of Biochemistry
2020
Novo Nordisk Foundation Center for Basic Metabolic Research
2014-2018
Foundation Center
2014-2018
Sanofi (India)
2016
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe Illumina-based metagenomic sequencing, assembly characterization 3.3 million non-redundant microbial genes, derived from 576.7 gigabases sequence, faecal samples 124 European individuals. The gene set, ∼150 times larger than complement, contains an overwhelming majority prevalent (more frequent) genes cohort probably includes a large proportion intestinal...
Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved colorectal carcinogenesis. identity and functional capacity of adenoma- or carcinoma-related microbe(s), however, have not been surveyed comprehensive manner. Here we perform metagenome-wide association study (MGWAS) on stools advanced adenoma carcinoma patients healthy subjects, revealing microbial genes, strains...
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes.We performed metagenome-wide association studies on samples 74 patients with CRC and 54 controls China, validated results in 16 24 Denmark. We further biomarkers two published cohorts France Austria. Finally, we employed targeted quantitative PCR (qPCR) assays to diagnostic of selected an independent Chinese cohort 47 109 controls.Besides confirming known associations Fusobacterium nucleatum...
We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the research ecosystem, from scientists and engineers clinicians policy makers. 2 provides new features that will drive next generation of research. These include interactive spatial temporal analysis visualization tools, support for metabolomics shotgun metagenomics analysis, automated provenance tracking ensure reproducible, transparent science.
We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the research ecosystem, from scientists and engineers clinicians policy makers. 2 provides new features that will drive next generation of research. These include interactive spatial temporal analysis visualization tools, support for metabolomics shotgun metagenomics analysis, automated provenance tracking ensure reproducible, transparent science.
Simply Mycoplasma The bacterium pneumoniae , a human pathogen, has genome of reduced size and is one the simplest organisms that can reproduce outside host cells. As such, it represents an excellent model organism in which to attempt systems-level understanding its biological organization. Now three papers provide comprehensive quantitative analysis proteome, metabolic network, transcriptome M. (see Perspective by Ochman Raghavan ). Anticipating what might be possible future for more complex...
Despite increasing concerns over inappropriate use of antibiotics in medicine and food production, population-level resistance transfer into the human gut microbiota has not been demonstrated beyond individual case studies. To determine “antibiotic potential” for entire microbial communities, we employ metagenomic data quantify totality known genes each community (its resistome) 68 classes subclasses antibiotics. In 252 fecal metagenomes from three countries, show that most abundant...