Simon Rasmussen
A5072477553- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Genetic diversity and population structure
- Microbial Community Ecology and Physiology
- Archaeology and ancient environmental studies
- Forensic Anthropology and Bioarchaeology Studies
- Yersinia bacterium, plague, ectoparasites research
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Race, Genetics, and Society
- Streptococcal Infections and Treatments
- Molecular Biology Techniques and Applications
- Machine Learning in Healthcare
- Immune Response and Inflammation
- interferon and immune responses
- Artificial Intelligence in Healthcare
- AI in cancer detection
- Environmental DNA in Biodiversity Studies
- Infective Endocarditis Diagnosis and Management
Novo Nordisk Foundation
2018-2025
University of Copenhagen
1978-2025
Broad Institute
2023-2025
Foundation Center
2023-2025
Novo Nordisk (United States)
2023-2025
Novo Nordisk Foundation Center for Basic Metabolic Research
2024
Novo Nordisk (Denmark)
2024
Technical University of Denmark
2012-2023
Rigshospitalet
1978-2022
Statens Serum Institut
2022
ObjectivesIdentification of antimicrobial resistance genes is important for understanding the underlying mechanisms and epidemiology resistance. As costs whole-genome sequencing (WGS) continue to decline, it becomes increasingly available in routine diagnostic laboratories anticipated substitute traditional methods gene identification. Thus, current challenge extract relevant information from large amount generated data.
ABSTRACT Accurate strain identification is essential for anyone working with bacteria. For many species, multilocus sequence typing (MLST) considered the “gold standard” of typing, but it traditionally performed in an expensive and time-consuming manner. As costs whole-genome sequencing (WGS) continue to decline, becomes increasingly available scientists routine diagnostic laboratories. Currently, cost below that traditional MLST. The new challenges will be how extract relevant information...
ABSTRACT Double-stranded RNA (dsRNA) longer than 30 bp is a key activator of the innate immune response against viral infections. It widely assumed that generation dsRNA during genome replication trait shared by all viruses. However, to our knowledge, no study exists in which production different viruses systematically investigated. Here, we investigated presence and localization cells infected with range viruses, employing dsRNA-specific antibody for immunofluorescence analysis. Our data...
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations difficult. Here, we use metagenomic analysis of untreated sewage characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences abundance and diversity genes between Europe/North-America/Oceania Africa/Asia/South-America. taxonomy only explains minor part variation that observe. no evidence cross-selection...
Whole-genome data indicate that early modern humans expanded into Australia 62,000 to 75,000 years ago.
How and when the Americas were populated remains contentious. Using ancient modern genome-wide data, we found that ancestors of all present-day Native Americans, including Athabascans Amerindians, entered as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) after more an 8000-year isolation period in Beringia. After their arrival to Americas, ancestral Americans diversified into two basal genetic branches around 13 ka, one is now dispersed across North South...
Abstract Biotic and abiotic stresses limit agricultural yields, plants are often simultaneously exposed to multiple stresses. Combinations of such as heat drought or cold high light intensity have profound effects on crop performance yields. Thus, delineation the regulatory networks metabolic pathways responding single concurrent is required for breeding engineering stress tolerance. Many studies described transcriptome changes in response However, exposure a combination factors may require...
The human occupation history of Southeast Asia (SEA) remains heavily debated. Current evidence suggests that SEA was occupied by Hòabìnhian hunter-gatherers until ~4000 years ago, when farming economies developed and expanded, restricting foraging groups to remote habitats. Some argue agricultural development indigenous; others favor the "two-layer" hypothesis posits a southward expansion farmers giving rise present-day Asian genetic diversity. By sequencing 26 ancient genomes (25 from SEA,...
The Yamnaya expansions from the western steppe into Europe and Asia during Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages possibly horse husbandry. We analyzed 74 ancient whole-genome sequences across Inner Anatolia show that Botai people associated earliest husbandry derived a hunter-gatherer population deeply diverged Yamnaya. Our results also suggest distinct migrations bringing West Eurasian ancestry South before after, but not at time of,...
Present-day hunter-gatherers (HGs) live in multilevel social groups essential to sustain a population structure characterized by limited levels of within-band relatedness and inbreeding. When these wider networks evolved among HGs is unknown. To investigate whether the contemporary HG strategy was already present Upper Paleolithic, we used complete genome sequences from Sunghir, site dated ~34,000 years before present, containing multiple anatomically modern human individuals. We show that...
One of the first issues that emerges when a prokaryotic organism interest is encountered question what it is--that is, which species is. The 16S rRNA gene formed basis method for sequence-based taxonomy and has had tremendous impact on field microbiology. Nevertheless, been found to have number shortcomings. In current study, we trained benchmarked five methods whole-genome identification common data set complete genomes: (i) SpeciesFinder, based gene; (ii) Reads2Type searches...