A5000935233- Vector-borne infectious diseases
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Genetic factors in colorectal cancer
- Insect and Pesticide Research
- Genetic and phenotypic traits in livestock
- Antibiotic Resistance in Bacteria
- Hypothalamic control of reproductive hormones
- Colorectal Cancer Treatments and Studies
- Estrogen and related hormone effects
- Vector-Borne Animal Diseases
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- Pleural and Pulmonary Diseases
- Cell Image Analysis Techniques
- Effects of Environmental Stressors on Livestock
- Helicobacter pylori-related gastroenterology studies
- Genomics and Phylogenetic Studies
- Gallbladder and Bile Duct Disorders
- Probiotics and Fermented Foods
University of Veterinary Medicine
2016-2025
Eötvös Loránd University
2010-2025
HUN-REN Szegedi Biológiai Kutatóközpont
2021
Institute of Plant Biology
2021
Nuremberg Hospital
2019
Klinikum Saarbrücken
2019
Krankenhaus Barmherzige Brüder
2019
University Hospital Heidelberg
2019
Heidelberg University
2019
Magyar Agrár- és Élettudományi Egyetem
2007-2017
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations difficult. Here, we use metagenomic analysis of untreated sewage characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences abundance and diversity genes between Europe/North-America/Oceania Africa/Asia/South-America. taxonomy only explains minor part variation that observe. no evidence cross-selection...
Abstract Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic genes (ARGs) essential develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing analyse ARGs in 757 sewage samples from 243 cities 101 countries, collected 2016 2019. We find regional patterns resistomes, these differ between subsets corresponding drug classes are partly driven by taxonomic variation....
Abstract The increasing prevalence of antimicrobial resistance (AMR) is a significant threat to global health. More and more multi-drug-resistant bacterial strains cause life-threatening infections the death thousands people each year. Beyond disease control animals are often given antibiotics for growth promotion or increased feed efficiency, which further increase chance development multi-resistant strains. After consumption unprocessed animal products, these may meet human bacteriota....
BackgroundAntimicrobial resistance (AMR) is caused by AMR determinants, mainly genes (ARGs) in the bacterial genome. Bacteriophages, integrative mobile genetic elements (iMGEs) or plasmids can allow ARGs to be exchanged among bacteria horizontal gene transfer (HGT). Bacteria, including with ARGs, found food. Thus, it conceivable that gastrointestinal tract, from gut flora could take up food.AimThe study objective was gain insight into ARG set carried commonly used probiotic may enter human...
Abstract. A survey was conducted in order to gain current information on flea species (Siphonaptera: Pulicidae) infesting dogs and cats living urban rural areas of Hungary, along with data the factors that affect presence, distribution seasonality infestation. In addition, owner awareness infestation evaluated. Practitioners 13 veterinary clinics were asked examine all attending clinic collect fleas, when present, 2 days each month from December 2005 November 2006. They also completed a...
Spontaneous rupture of the esophagus (Boerhaave syndrome) is an extremely rare, life-threatening condition. Traditionally surgery was treatment choice. Endoscopic stent insertion offers a promising alternative. The aim this study to compare results primary surgical therapy with endoscopic stenting. A British and German high-volume center for esophageal participated in retrospective study. At center, operative (primary repair or drainage) routinely carried out. option at center. Only patients...
Abstract The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection unusual emergence spread should therefore include such cities as part risk-based surveillance. A catch-all metagenomic sequencing approach urban sewage could potentially provide an unbiased insight into dynamics viral pathogens circulating in community irrespective access to care, potential which already has been proven...
Even though people worldwide tend to consume probiotic products for their beneficial health effects on a daily basis, recently, concerns were outlined regarding the uptake and potential intestinal colonisation of bacteria that they carry. These are capable executing horizontal gene transfer (HGT) which facilitates movement various genes, including antimicrobial resistance genes (ARGs), among donor recipient bacterial populations. Within our study, 47 shotgun sequencing datasets deriving from...
Treatment of colorectal adenomas with selective cyclooxygenase-2 inhibitors can contribute to the chemoprevention cancer (CRC), but molecular background their effect is not fully understood. We analysed gene expression modulatory N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS398) on HT29 cells be correlated data gained from biopsy samples. colon adenocarcinoma were treated NS398, and global mRNA was HGU133Plus2.0 microarrays. Discriminatory transcripts between normal adenoma CRC...
Gene expression profile (GEP)-based classification of colonic diseases is a new method for diagnostic purposes. Our aim was to develop mRNA patterns that may establish the basis molecular biological method.Total RNA extracted, amplified, and biotinylated from frozen biopsies patients with colorectal cancer (n=22), adenoma (n=20), hyperplastic polyp (n=11), inflammatory bowel disease (n=21), healthy normal controls as well peripheral blood samples 19 11 patients. Genome-wide gene evaluated by...
Abstract Background Estrogens exert anti-inflammatory and neuroprotective effects in the brain mainly via estrogen receptors α (ERα) β (ERβ). These are members of nuclear receptor superfamily ligand-dependent transcription factors. This study was aimed at elucidation ERα ERβ agonists on expression neuroinflammatory genes frontal cortex aging female rats. Methods To identify estrogen-responsive immunity/inflammation genes, we treated middle-aged, ovariectomized rats with 17β-estradiol (E2),...
Our bloodstream is considered to be an environment well separated from the outside world and digestive tract. According standard paradigm large macromolecules consumed with food cannot pass directly circulatory system. During digestion proteins DNA are thought degraded into small constituents, amino acids nucleic acids, respectively, then absorbed by a complex active process distributed various parts of body through circulation Here, based on analysis over 1000 human samples four independent...
The intricate interactions between the immune, endocrine and central nervous systems shape innate immune response of brain. We have previously shown that estradiol suppresses expression genes in frontal cortex middle-aged ovariectomized rats, but not young ones reflecting elevated these middle-aged, ovarian hormone deficient animals. Here, we explored impact menopause on microglia phenotype capitalizing differential macrophage-associated quiescent activated microglia. selected twenty-three...
Recently, Hepatozoon canis infection has been detected among shepherd, hunting and stray dogs in the southern part of Hungary, which is considered to be free Rhipicephalus sanguineus sensu lato close border with Croatia. The aim this study was acquire information on possibility that red foxes and/or golden jackals could play a role appearance spread H. Hungary.A conventional PCR used amplify 666 bp long fragment 18S rRNA gene from blood samples collected 334 shot 231 locations 16 counties 15...
In the hippocampus, estrogens are powerful modulators of neurotransmission, synaptic plasticity and neurogenesis. women, menopause is associated with increased risk memory disturbances, which can be attenuated by timely estrogen therapy. animal models menopause, 17β-estradiol (E2) replacement improves hippocampus-dependent spatial memory. Here, we explored effect E2 on hippocampal gene expression in a rat model. Middle-aged ovariectomized female rats were treated continuously for 29 days E2,...
Small extracellular vesicles (EVs) are membrane enclosed structures that usually released from cells upon exocytosis of multivesicular bodies (MVBs) as a collection separate, free EVs. In this study, we analysed paraffin embedded sections archived human colorectal cancer samples. We studied 3D reconstructions confocal microscopic images complemented by HyVolution and STED imaging. Unexpectedly, found evidence large, MVB-like aggregates ALIX/CD63 positive EV clusters were en bloc migrating...
Abstract Antimicrobial resistance (AMR) is a global threat gaining more and practical significance every year. The main determinants of AMR are the antimicrobial genes (ARGs). Since bacteria can share genetic components via horizontal gene transfer, even non-pathogenic may provide ARG to any pathogens which they become physically close (e.g. in human gut). In addition, fermented food naturally contains high amounts. this study, we examined diversity content various kefir yoghurt samples...