A5039207307- Essential Oils and Antimicrobial Activity
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Escherichia coli research studies
- Orthopedic Infections and Treatments
- Immune Response and Inflammation
- Microfluidic and Capillary Electrophoresis Applications
- Glioma Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Antifungal resistance and susceptibility
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Bacterial biofilms and quorum sensing
- Gut microbiota and health
- Lipid Membrane Structure and Behavior
- Bee Products Chemical Analysis
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Enterobacteriaceae and Cronobacter Research
- Viral gastroenteritis research and epidemiology
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
Semmelweis University
2016-2025
University of Pecs
2016-2025
Sapientia Hungarian University of Transylvania
2019
Institute of Biophysics
2015
Hungarian Academy of Sciences
2015
HUN-REN Szegedi Biológiai Kutatóközpont
2015
University of Verona
2010-2013
St. John's University
2010
HUN-REN Institute of Experimental Medicine
2008
Queen Square Radiosurgery Centre
2006
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations difficult. Here, we use metagenomic analysis of untreated sewage characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences abundance and diversity genes between Europe/North-America/Oceania Africa/Asia/South-America. taxonomy only explains minor part variation that observe. no evidence cross-selection...
Abstract Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic genes (ARGs) essential develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing analyse ARGs in 757 sewage samples from 243 cities 101 countries, collected 2016 2019. We find regional patterns resistomes, these differ between subsets corresponding drug classes are partly driven by taxonomic variation....
ABSTRACT The management of staphylococcal diseases is increasingly difficult with present medical approaches. Preventive and therapeutic vaccination considered to be a promising alternative; however, little known about immune correlates protection disease susceptibility. To better understand the recognition Staphylococcus aureus by human host, we studied antistaphylococcal humoral responses in healthy people comparison those patients invasive diseases. In series enzyme-linked immunosorbent...
Abstract Here, we measured the concentrations of several ions in cultivated Gram-negative and Gram-positive bacteria, analyzed their effects on polymer formation by actin homologue MreB. We potassium, sodium, chloride, calcium magnesium ion Leptospira interrogans , Bacillus subtilis Escherichia coli . Intracellular ionic strength contributed from these varied within 130–273 mM range. The intracellular sodium concentration range was between 122 296 potassium 5 38 mM. However, levels were...
Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen considered one of the paradigms antimicrobial resistance, is among main causes hospital-acquired and chronic infections associated with significant morbidity mortality. This growing threat results from extraordinary capacity P. aeruginosa to develop resistance through chromosomal mutations, increasing prevalence transferable determinants (such as carbapenemases extended-spectrum β-lactamases), global expansion epidemic lineages. The...
The increasing number of multidrug-resistant bacteria and the fact antibiotic resistance is leading to a continuous need for discovering alternative treatments against infections, e.g. in case respiratory tract diseases. Essential oils (EOs), because their volatility, can easily reach both upper lower parts via inhalation. Therefore, aim present study was antibacterial evaluation clove, cinnamon bark, eucalyptus, thyme, scots pine, peppermint, citronella EOs pathogens such as Streptococcus...
Abstract The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection unusual emergence spread should therefore include such cities as part risk-based surveillance. A catch-all metagenomic sequencing approach urban sewage could potentially provide an unbiased insight into dynamics viral pathogens circulating in community irrespective access to care, potential which already has been proven...
Honey is known as an alternative remedy for the treatment of wounds. To evaluate potential five Hungarian honey types against wound-associated bacteria, in vitro microbiological assays were conducted on Pseudomonas aeruginosa, Staphylococcus epidermidis and methicillin-resistant aureus (MRSA). Minimum inhibitory concentration (MIC) was determined with broth macrodilution method, biofilm degradation capacity tested a crystal violet assay. understand underlying mechanisms, effects treatments...
Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on detailed spectrum has not been explored yet. We investigated antibiotics (ABx) and/or probiotics, four treatment groups rat stool composition. Principal component analysis indicated that chromatogram profiles differ, which was also observed at different...
Abstract Essential oils are well‐known for their antimicrobial activity against different plant and human pathogenic microorganisms. The results of the most commonly used assays very different; sometimes reliability is questionable, therefore standardized methods need to be solve this problem. present study aims at phytochemical characterization some essential (thyme, lavender, eucalyptus, spearmint cinnamon) that important from therapeutic economic aspects optimized microbiological...
Abstract The prevalence of autism spectrum disorder (ASD) has rapidly increased in the past decades, and several studies report about escalating use antibiotics consequent disruption gastrointestinal microbiome leading to development neurobehavioral symptoms resembling those ASD. primary purpose this study was investigate whether depletion via treatment could induce ASD-like behavioral adulthood. To reliably evaluate that, validated valproic acid (VPA) ASD animal model introduced. At last,...
The proline-rich designer antibacterial peptide dimer A3-APO is currently under preclinical development for the treatment of systemic infections caused by antibiotic-resistant Gram-negative bacteria. showed remarkable stability in 25% mouse serum vitro, exhibiting a half-life approximately 100 min as documented reversed-phase chromatography. Indeed, after 30-min incubation period undiluted ex vivo, mass spectrometry failed to identify any degradation product. was still major peak full blood...
Additive manufacturing technologies give many new application possibilities in our everyday life. Biomedical applications benefit a lot from 3D printing. In medical applications, several devices can be easily produced or prototyped with FFF/FDM technologies, but we must minimize the contamination risk. New materials regularly appear on market, recently specified as antibacterial, resulting compounded silver nanoparticles. Because scientifically accurate and practical information is not...
Purpose Metronidazol and vancomycin were long the two best options against Clostridioides (formerly Clostridium ) difficile infections (CDI). Now, cost of new drugs such as fidaxomicin directs us towards alternative treatment options, faecal microbiota transplant (FMT). Its effectiveness is similar to fidaxomicin. There are questions regarding its safety, but biggest challenges prejudice inconvenience. Most protocols refer FMT applied in form a solution. We investigated different modalities...
Honey is a rich source of carbohydrates, while minor compounds such as amino acids and polyphenols contribute to its health-promoting effects. one the oldest traditional remedies applied for microbial infections, due antibacterial, anti-inflammatory, antioxidant properties. The aim this study was investigate antibacterial antibiofilm effects Hungarian black locust, linden, sunflower honeys against most common biofilm-forming respiratory tract pathogens Haemophilus spp., Pseudomonas...
Essential oils (EOs) with established and well-known activities against human pathogens might become new therapeutics in multidrug-resistant bacterial infections, including respiratory tract infections. The aim of this study was to evaluate the antimicrobial activity EOs obtained from several samples Origanum vulgare, O. syriacum, majorana cultivated Poland. were analyzed by GC-MS tested four strains: Staphylococcus aureus (MRSA), Haemophilus influenzae, parainfluenzae, Pseudomonas...