Ripan S. Malhi
A5040631295- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Archaeology and ancient environmental studies
- Genetic diversity and population structure
- Race, Genetics, and Society
- Indigenous Studies and Ecology
- Genomics and Phylogenetic Studies
- Primate Behavior and Ecology
- Genetic and phenotypic traits in livestock
- Identification and Quantification in Food
- Wildlife Ecology and Conservation
- Human-Animal Interaction Studies
- Molecular Biology Techniques and Applications
- Pleistocene-Era Hominins and Archaeology
- Amphibian and Reptile Biology
- Yersinia bacterium, plague, ectoparasites research
- Gut microbiota and health
- Environmental DNA in Biodiversity Studies
- Ethics in Clinical Research
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Bat Biology and Ecology Studies
- Zoonotic diseases and public health
- HIV Research and Treatment
- Paleopathology and ancient diseases
University of Illinois Urbana-Champaign
2015-2024
Urbana University
2013-2024
American Institute of Indian Studies
2023
Southern Illinois University School of Medicine
2020
University of South Carolina
2020
Arctic and Antarctic Research Institute
2018
University of Reading
2017
University of Chicago
2016
Museum of Indian Arts and Culture
2012-2014
Davenport University
2009
Native Americans derive from a small number of Asian founders who likely arrived to the Americas via Beringia. However, additional details about intial colonization remain unclear. To investigate pioneering phase in we analyzed total 623 complete mtDNAs and Asia, including 20 new seven Asia. This sequence data was used direct high-resolution genotyping American 26 populations. Here describe more genetic diversity within founder population than previously reported. The newly resolved...
How and when the Americas were populated remains contentious. Using ancient modern genome-wide data, we found that ancestors of all present-day Native Americans, including Athabascans Amerindians, entered as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) after more an 8000-year isolation period in Beringia. After their arrival to Americas, ancestral Americans diversified into two basal genetic branches around 13 ka, one is now dispersed across North South...
Studies of the peopling Americas have focused on timing and number initial migrations. Less attention has been paid to subsequent spread people within Americas. We sequenced 15 ancient human genomes spanning from Alaska Patagonia; six are ≥10,000 years old (up ~18× coverage). All most closely related Native Americans, including those an Ancient Beringian individual two morphologically distinct "Paleoamericans." found evidence rapid dispersal early diversification that included previously...
Kennewick Man, a 8,500-year-old male human skeleton discovered in Washington state, USA, has been the subject of scientific and legal controversy; here DNA analysis shows that Man is closer to modern Native Americans than any other extant population worldwide. 9,000-year-old USA 1996. The affinities remains have controversy. Initial studies based on morphology suggested was not American affinity. Eske Willerslev colleagues now present showing fact referred as Ancient One by Americans, state...
Because of differences in craniofacial morphology and dentition between the earliest American skeletons modern Native Americans, separate origins have been postulated for them, despite genetic evidence to contrary. We describe a near-complete human skeleton with an intact cranium preserved DNA found extinct fauna submerged cave on Mexico's Yucatan Peninsula. This dates 13,000 12,000 calendar years ago has Paleoamerican characteristics Beringian-derived mitochondrial (mtDNA) haplogroup (D1)....
Dogs were present in the Americas before arrival of European colonists, but origin and fate these precontact dogs are largely unknown. We sequenced 71 mitochondrial 7 nuclear genomes from ancient North American Siberian time frames spanning ~9000 years. Our analysis indicates that not derived wolves. Instead, form a monophyletic lineage likely originated Siberia dispersed into alongside people. After Europeans, native almost completely disappeared, leaving minimal genetic legacy modern dog...
Advances in the isolation and sequencing of ancient DNA have begun to reveal population histories both people dogs. Over last 10,000 y, genetic signatures dog remains been linked with known human dispersals regions such as Arctic remote Pacific. It is suspected, however, that this relationship has a much deeper antiquity, tandem movement dogs may soon after domestication from gray wolf ancestor late Pleistocene. Here, by comparing results humans Siberia, Beringia, North America, we show...
Abstract Mitochondrial and Y‐chromosome DNA were analyzed from 10,300‐year‐old human remains excavated On Your Knees Cave on Prince of Wales Island, Alaska (Site 49‐PET‐408). This individual's mitochondrial (mtDNA) represents the founder haplotype an additional subhaplogroup haplogroup D that was brought to Americas, demonstrating widely held assumptions about genetic composition earliest Americans are incorrect. The amount diversity has accumulated in over past 10,300 years suggests...
A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed this phenomenon, here we analyse 50 exomes continuous from Northwest Coast North America, dating before and contact. We model collapse contact, inferring 57% reduction in effective size. also identify signatures positive selection on immune-related genes ancient but not modern group,...
In this study we evaluated migration models to the Americas by using information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent Eskimo–Aleut northern Na-Dene speakers, revealed that haplogroup arose America ∼11–13 ka one founder Paleo-Indian B2 mitogenomes. contrast, A2a, is typical Eskimo–Aleuts Na-Dene, but also present easternmost Siberian groups, originated only 4–7 Alaska, led first...
Founder effects in modern populations The genomes of ancient humans can reveal patterns early human migration (see the Perspective by Achilli et al. ). Iceland has a genetically distinct population, despite relatively recent settlement (∼1100 years ago). Ebenesersdóttir examined Icelandic people, dating to near colonization Iceland, and compared them with modernday populations. DNA revealed that founders had Gaelic Norse origins. Genetic drift since initial left Icelanders allele frequencies...
Recent genomic studies of both ancient and modern indigenous people the Americas have shed light on demographic processes involved during first peopling. The Pacific Northwest Coast proves an intriguing focus for these because its association with coastal migration models genetic ancestral patterns that are difficult to reconcile DNA alone. Here, we report low-coverage genome sequence individual known as "Shuká Káa" ("Man Ahead Us") recovered from On Your Knees Cave (OYKC) in southeastern...
Ancestral remains should be regarded not as “artifacts” but human relatives who deserve respect
Abstract Grey wolves ( Canis lupus ) are one of the few large terrestrial carnivores that have maintained a wide geographical distribution across Northern Hemisphere throughout Pleistocene and Holocene. Recent genetic studies suggested that, despite this continuous presence, major demographic changes occurred in wolf populations between Late early Holocene, extant trace their ancestry to single population. Both origin ancestral population how it became widespread remain unknown. Here, we...
Sex estimation of skeletons is fundamental to many archaeological studies. Currently, three approaches are available estimate sex-osteology, genomics, or proteomics, but little known about the relative reliability these methods in applied settings. We present matching osteological, shotgun-genomic, and proteomic data sex 55 individuals, each with an independent radiocarbon date between 2,440 100 cal BP, from two ancestral Ohlone sites Central California. was possible 100% this burial sample...
Mitochondrial DNA (mtDNA) samples of 70 Native Americans, most whom had been found not to belong any the four common American haplogroups (A, B, C, and D), were analyzed for presence Dde I site losses at np 1715 10394. These two mutations are characteristic haplogroup X which might be European origin. The first hypervariable segment (HVSI) non-coding control region (CR) mtDNA a representative selection exhibiting these was sequenced confirm their assignment X. Thirty-two exhibited...