Baharak Hooshiar Kashani
A5091880412- Forensic and Genetic Research
- Genetic diversity and population structure
- Yersinia bacterium, plague, ectoparasites research
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Forensic Anthropology and Bioarchaeology Studies
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic and phenotypic traits in livestock
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Metabolism and Genetic Disorders
- Extracellular vesicles in disease
- Gut microbiota and health
- Plant Disease Resistance and Genetics
- Chromosomal and Genetic Variations
- Race, Genetics, and Society
- Cleft Lip and Palate Research
- Animal Diversity and Health Studies
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- Mycobacterium research and diagnosis
- Inhalation and Respiratory Drug Delivery
- Veterinary Equine Medical Research
- Maritime and Coastal Archaeology
German Center for Lung Research
2022-2023
Helmholtz Zentrum München
2022-2023
University of Pavia
2008-2022
Ludwig-Maximilians-Universität München
2022
Université Libre de Bruxelles
2018
National Institute of Genetic Engineering and Biotechnology
2003-2007
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations individual the variability present in population. Here we integrated Human Lung Cell Atlas (HLCA), combining 49 respiratory system into single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents consensus re-annotation with...
Archaeological and genetic evidence concerning the time mode of wild horse ( Equus ferus ) domestication is still debated. High levels diversity in mtDNA have been detected when analyzing control region; recurrent mutations, however, tend to blur structure phylogenetic tree. Here, we brought phylogeny highest level molecular resolution by 83 mitochondrial genomes from modern horses across Asia, Europe, Middle East, Americas. Our data reveal 18 major haplogroups (A–R) with radiation times...
ABSTRACT Organ- and body-scale cell atlases have the potential to transform our understanding of human biology. To capture variability present in population, these must include diverse demographics such as age ethnicity from both healthy diseased individuals. The growth size number single-cell datasets, combined with recent advances computational techniques, for first time makes it possible generate comprehensive large-scale through integration multiple datasets. Here, we integrated Human...
Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages geographical distributions that indicative an early arrival from Beringia with Paleo-Indians. In contrast, the estimated C1d--the third subset C1--looked too young to fit above scenario. To define origin this enigmatic branch, we completely sequenced 63 C1d genomes a wide range geographically diverse, mixed, indigenous American...
In this study we evaluated migration models to the Americas by using information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent Eskimo–Aleut northern Na-Dene speakers, revealed that haplogroup arose America ∼11–13 ka one founder Paleo-Indian B2 mitogenomes. contrast, A2a, is typical Eskimo–Aleuts Na-Dene, but also present easternmost Siberian groups, originated only 4–7 Alaska, led first...
Sakha--an area connecting South and Northeast Siberia--is significant for understanding the history of peopling Eurasia Americas. Previous studies have shown a genetic contiguity between Siberia East Asia key role in colonization Siberia.We report results high-resolution phylogenetic analysis 701 mtDNAs 318 Y chromosomes from five native populations Sakha (Yakuts, Evenks, Evens, Yukaghirs Dolgans) more than 500,000 autosomal SNPs 758 individuals 55 populations, including 40 previously...
Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization male lineages in Middle East southwestern Asia. At present, Iranian population is characterized by an extraordinary mix different ethnic groups speaking a variety Indo-Iranian, Semitic Turkic languages. Despite these features, only few studies have investigated multiethnic components gene pool. In this survey 938 DNAs belonging...
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms and fibrogenesis directly in human tissue has been hampered by the lack organotypic models analytical techniques. In this work, we coupled ex vivo cytokine drug perturbations precision-cut lung slices (hPCLS) with single-cell RNA sequencing induced multilineage circuit fibrogenic cell states hPCLS. We showed that these were highly similar to multicohort atlas from patients pulmonary...
Cytotoxic CD4 (CD4CTX) T cells are emerging as an important component of antiviral and antitumor immunity, but the molecular basis their development remains poorly understood. In context human cytomegalovirus infection, a significant proportion displays cytotoxic functions. We observed that transcriptional program these was enriched in CD8 cell lineage genes despite absence ThPOK downregulation. further show establishment CD4CTX-specific epigenetic programs occurred stepwise fashion along...
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, mitochondrial DNA (mtDNA) mutations have shown to be causal for T2DM pathogenesis. So far, many studies investigated the possibility that mtDNA variation might affect risk T2DM, however, when found, haplogroup association rarely replicated, even related populations, possibly due an inadequate level resolution. Effects on complications also proposed. However, additional evaluating...
Abstract Recent analyses of mitochondrial genomes from Native Americans have brought the overall number recognized maternal founding lineages just four to a current count 15. However, because their relative low frequency, almost nothing is known for some these lineages. This leaves considerable void in understanding events that led colonization Americas following Last Glacial Maximum (LGM). In this study, we identified and completely sequenced 14 DNAs belonging one extremely rare American...
The current human mitochondrial (mtDNA) phylogeny does not equally represent all populations but is biased in favour of representatives originally from north and central Europe. This especially affects the some uncommon West Eurasian haplogroups, including I W, whose southern European Near Eastern components are very poorly represented, suggesting that extensive hidden phylogenetic substructure remains to be uncovered. study expanded re-analysed available datasets W complete mtDNA genomes,...
Abstract Background For millennia, the southern part of Mesopotamia has been a wetland region generated by Tigris and Euphrates rivers before flowing into Gulf. This area occupied human communities since ancient times present-day inhabitants, Marsh Arabs, are considered population with strongest link to Sumerians. Popular tradition, however, considers Arabs as foreign group, unknown origin, which arrived in marshlands when rearing water buffalo was introduced region. Results To shed some...
Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting Republic Belarus. together with Ukrainians Russians represent East Slavic linguistic group, largest both in numbers territory, Europe alongside Baltic-, Finno-Permic- Turkic-speaking people. Till date, only a limited number low resolution genetic studies have been performed on this population. Therefore, phylogeographic analysis 565 Y-chromosomes 267 mitochondrial DNAs from six well covered geographic...
The Tuareg of the Fezzan region (Libya) are characterized by an extremely high frequency (61%) haplogroup H1, a mitochondrial DNA (mtDNA) that is common in all Western European populations. To define how and when H1 spread from Europe to North Africa up Central Sahara, Fezzan, we investigated complete genomes eleven Libyan belonging H1. Coalescence time estimates suggest arrival mtDNAs at about 8,000–9,000 years ago, while phylogenetic analyses reveal three novel branches, termed H1v, H1w...
Abstract Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups present-day populations of Europe. While most subclades are older than 30 thousand years, comparatively recent coalescence time extant variation U7 (~16–19 years ago) suggests its current distribution consequence more dispersal events, despite wide geographical range across...
ABSTRACT Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms and fibrogenesis directly in human tissue has been hampered by the lack organotypic models analytical techniques. In this work, we coupled ex vivo cytokine drug perturbations precision-cut lung slices (hPCLS) with scRNAseq induced multi-lineage circuit fibrogenic cell states hPCLS, which show to be highly similar multi-cohort atlas from pulmonary patients. Using micro-CT staged...