A5080424591- Inhalation and Respiratory Drug Delivery
- Nanoparticles: synthesis and applications
- Random lasers and scattering media
- Nuclear Physics and Applications
- Nanoparticle-Based Drug Delivery
- Air Quality and Health Impacts
- Optical Coherence Tomography Applications
- Advanced X-ray Imaging Techniques
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Air Quality Monitoring and Forecasting
- Traditional Chinese Medicine Analysis
- Cardiac electrophysiology and arrhythmias
- Extracellular vesicles in disease
- Image and Video Quality Assessment
- Escherichia coli research studies
- Civil and Geotechnical Engineering Research
- Microfluidic and Bio-sensing Technologies
- Medical Imaging Techniques and Applications
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Climate change and permafrost
- Salmonella and Campylobacter epidemiology
- Graphene and Nanomaterials Applications
- Neurological Disease Mechanisms and Treatments
Nanchang University
2009-2025
State Key Laboratory of Food Science and Technology
2013-2025
École Polytechnique Fédérale de Lausanne
2024
Helmholtz Zentrum München
2018-2024
German Center for Lung Research
2018-2024
Jiangxi University of Traditional Chinese Medicine
2021-2024
Xi'an Medical University
2023
Huaian First People’s Hospital
2022
Qingdao University
2021
Affiliated Hospital of Qingdao University
2021
Nanoparticles (NPs) size, surface functionalization, and concentration were claimed to contribute distribution toxicity outcomes of NPs in vivo. However, intrinsic chemical compositions caused inconsistent biodistribution toxic profiles which attracted little attention. In this study, silver nanoparticles (AgNPs) gold (AuNPs) used determine the biodistribution, toxickinetic, genotoxicity variances murine animals. The results demonstrated AgNPs AuNPs primarily deposited mononuclear phagocyte...
In spite of the immense benefits from iron oxide magnetic nanoparticles (IOMNs), there is scanty information regarding their metabolic activities and toxicity <italic>in vivo</italic>.
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms and fibrogenesis directly in human tissue has been hampered by the lack organotypic models analytical techniques. In this work, we coupled ex vivo cytokine drug perturbations precision-cut lung slices (hPCLS) with single-cell RNA sequencing induced multilineage circuit fibrogenic cell states hPCLS. We showed that these were highly similar to multicohort atlas from patients pulmonary...
Deciphering biodistribution, biokinetics, and biological effects of nanoparticles (NPs) in entire organs with cellular resolution remains largely elusive due to the lack effective imaging tools. Here, light sheet fluorescence microscopy combination optical tissue clearing was validated for concomitant three-dimensional mapping lung morphology NP biodistribution nondissected ex vivo murine lungs. Tissue autofluorescence allowed label-free, quantitative morphometry bronchial tree, acinar...
Abstract Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator‐induced) conditions is known to significantly impact all cellular compartments in the lung, thereby playing a pivotal role lung growth, regeneration disease development. In order evaluate of mechanical forces on level, vitro models using cells stretchable membranes have been developed. Only recently some these cell‐stretching devices become suitable for air–liquid interface cell cultures,...
Abstract We describe the first dynamic and in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The properties of this source enable time-sequence propagation-based phase-contrast imaging. focus here on non-invasive for respiratory treatment development physiological understanding. In small animals, we capture regional delivery treatment, two measures health that can reveal effectiveness treatment; lung motion mucociliary...
The variation of the integrity intestinal barrier is closely related to occurrence and progression various diseases, making its accurate detection monitoring essential provide reliable information for guiding refinement treatment scenarios. Herein, we developed a strategy utilizing glutathione-capped gold clusters (Au-GSH) achieve simultaneous in vivo second near-infrared (NIR-II) fluorescence imaging vitro colorimetric urinalysis noninvasive integrity. After oral administration, Au-GSH can...
Quantum ghost imaging uses quantum entanglement to generate a two-dimensional image with only bucket detector at the sample. Here we expand on this approach three-dimensional without scanning. A entangled light source directly links information between pair of 2D sensors; one which captures standard from perspective and second sensor perpendicular perspective. By correlating spatial two detectors for each photon pair, obtain three dimensions (x, y, z) scattered photon. We demonstrate that...
Quantum ghost imaging uses quantum entanglement to generate a two-dimensional image with only bucket detector at the sample. Here we expand on this approach three-dimensional without scanning. A entangled light source directly links information between pair of 2D sensors; one which captures standard from perspective and second sensor perpendicular perspective. By correlating spatial two detectors for each photon pair, obtain three dimensions (x, y, z) scattered photon. We demonstrate that...
X-ray grating interferometry is a powerful emerging tool in biomedical imaging, providing access to three complementary image modalities. In addition the conventional attenuation modality, provides phase which visualizes soft tissue structures, and dark-field relates number size of sub-resolution scattering objects. A particularly strong signal originates from alveoli or air sacs lung. Dark-field lung radiographs animal models have already shown increased sensitivity diagnosing diseases,...
QDs induced systemic injuries to dams in a dose-dependent and reversible manner retarded the offspring growth.
Targeted delivery of nanomedicine/nanoparticles (NM/NPs) to the site disease (e.g., tumor or lung injury) is vital importance for improved therapeutic efficacy. Multimodal imaging platforms provide powerful tools monitoring and tissue distribution drugs NM/NPs. This study introduces a preclinical platform combining X-ray (two modes) fluorescence (three techniques time-resolved in vivo spatially resolved ex visualization mouse lungs during pulmonary NP delivery. Liquid mixtures iodine...
Abstract ZnO nanoparticles (NPs) are among the most manufactured in consumer products, industries, and researches. An increasing body of evidence indicated that NPs show toxicological effects vivo. Sex differences toxicity not clear, thus aim this study was to investigate on female male reproductive organs (uterus, ovary testes). were orally administered mice at dosages level 0 100 mg/kg weight. The biological material sampled 3 days after tube feeding. results demonstrated Zinc contents...
Silver metals have long been known to possess antimicrobial properties. Recently, even the nanoparticle version of silver (AgNPs) has also established as antimicrobials. In this study AgNPs were combined with extracts medicinal plant Chinese honeysuckle, Lonicera japonica Thunb. The activity AgNPs-herb was tested against pathogenic Escherichia coli CMCC44113. Using different or herb (honeysuckle water extract HWE) ratios in presence a fixed concentration E. CMCC44113, potencies found be...
Kai-Xin-San (KXS) is a classic formula for the treatment of Alzheimer’s disease (AD). KXS has been widely used to treat emotional diseases; however, its active components remain unknown. There have some reports about efficacy and metabolic analysis KXS, which are mainly based on studying normal animals. The current work first established an AD rat model by injecting D-galactose into abdominal cavity Aβ25–35 hippocampus both sides, followed intragastric administration consecutive week; then,...