A5011424051- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- T-cell and B-cell Immunology
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Complement system in diseases
- Sepsis Diagnosis and Treatment
- Animal Virus Infections Studies
- Olfactory and Sensory Function Studies
Université Libre de Bruxelles
2016-2025
St George's, University of London
2025
City St George's, University of London
2025
University Hospital of Geneva
2024
University of Geneva
2024
Directorate-General for Health and Food Safety
2024
Sciensano (Belgium)
2021-2024
Instituut voor Tropische Geneeskunde
2021
Epicura
2020
Centre Hospitalier Universitaire de Saint-Pierre
2014-2020
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be particular interest preventing endotoxin-induced toxicity. We therefore examined the effects IL-10 administration before lipopolysaccharide (LPS) challenge mice. A marked reduction amounts LPS-induced tumor necrosis factor (TNF) release circulation was observed after pretreatment at doses low as U. also prevented hypothermia generated...
Data obtained in animals indicate that neonatal immune responses are biased toward Th2. This could reduce the efficacy of vaccines against viral and mycobacterial diseases. The ability human newborns to develop a Th1 response upon immunization has not been studied. Since vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) triggers Th1-type adults, we investigated whether it induces similar age at vaccination influences immunogenicity. We found BCG birth memory magnitude when given...
Abstract There is evidence that interleukin −10(IL‐10) interferes with the costimulatory properties of antigen‐presenting cells and, thereby, inhibits their ability to induce T cell activation. To determine whether this effect might involve modulation expression accessory molecules, we analyzed by flow cytometry influence human IL‐10 on basal intercellular adhesion molecule 1 (ICAM‐1) as well interferon γ(IFN‐γ)‐induced up‐regulation ICAM‐1 and B7 at surface monocytes. inhibited both...
Abstract Objective To investigate prevalence and recovery of olfactory dysfunction (OD) in COVID‐19 patients according to the disease severity. Methods From 22 March 3 June 2020, 2581 were identified from 18 European hospitals. Epidemiological clinical data extracted at baseline within 2‐month post‐infection. Results The OD was significantly higher mild form (85.9%) compared with moderate‐to‐critical forms (4.5–6.9%; P = 0.001). Of 1916 OD, 1363 completed evaluations (71.1%). A total 328...
Significance Despite their enormous potential for diversity (in excess of 10 15 theoretical receptor specificities), the human γδ T-cell repertoire is dominated by a specific subset expressing containing γ-chain variable region 9 and δ-chain 2 (Vγ9Vδ2) known to react set pathogen-derived small molecules (phosphoantigens). Overrepresentation this restricted T cells in adults has been thought reflect an antigen-specific selection process resulting from postnatal exposure pathogens. However, we...
Systems biology can unravel complex but has not been extensively applied to human newborns, a group highly vulnerable wide range of diseases. We optimized methods extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml blood, volume readily obtained newborns. Indexing baseline applying innovative integrative computational reveals dramatic changes along remarkably stable developmental trajectory over the first week life. This is...
Abstract Interleukin‐10 (IL‐10) is a potent inhibitor of lipopolysaccharide (LPS)‐induced tumor necrosis factor (TNF) production and has been shown to protect mice from endotoxin shock. As IFN‐γ another important mediator LPS toxicity, we studied the effects IL‐10 on LPS‐induced synthesis in vitro vivo . First, found that addition recombinant human (rhIL‐10) (10 U/ml) whole blood markedly suppressed release while neutralization endogenously synthesized resulted increased levels. The ability...
Abstract IL-10 production during endotoxic shock is part of a protective mechanism that involves IL-10-induced inhibition TNF synthesis. We sought to determine the role in septic peritonitis induced by cecal ligation and puncture (CLP). CLP led rapid induction mRNA various organs C57BI/6 mice. In liver, was detectable within 1 h following CLP, while spleen lungs, detected from 2 4 onward. protein became plasma after reaching peak concentrations 12 (12.7 +/- 5.7 ng/ml). Pretreatment (-2 h)...
Abstract The immaturity of the immune system increases susceptibility young infants to infectious diseases and prevents induction protective responses by vaccines. We previously reported that Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination induces a potent Th1 response mycobacterial Ags in newborns. In this study, we evaluated influence BCG on unrelated vaccines given early life. Newborns were randomly allocated one three study groups receiving at birth, when received their...
The effects of recombinant interleukin (IL)-10 and the role endogenous IL-10 were determined in C57B1/6 mice with pneumonia induced by intranasal inoculation 106 cfu Streptococcus pneumoniae. Pneumonia sustained expression IL-lO mRNA protein lungs, but remained undetectable plasma. Intranasal S. pneumoniae combination (1500 U/mouse) resulted decreased lung concentrations tumor necrosis factor-α (TNF) interferon (lFN)-γ, increased bacterial counts lungs blood, early lethality. Conversely,...
Immunization of newborns against viral infections may be hampered by ineffective CD8(+) T cell responses. To characterize the function lymphocytes in early life, we studied with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection utero leads to expansion and differentiation mature HCMV-specific cells, which have similar characteristics those detected adults. High frequencies cells were ex vivo tetramer staining as after 28 weeks gestation. During acute phase...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function lymphocytes in early life, we studied with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection utero leads to expansion and differentiation mature HCMV-specific cells, which have similar characteristics those detected adults. High frequencies cells were ex vivo tetramer staining as after 28 weeks gestation. During acute phase...
The fetus and infant are highly susceptible to viral infections. Several viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared with later life. It is generally accepted that this a result of the immaturity immune system. gammadelta T cells unconventional can react rapidly upon activation show major histocompatibility complex-unrestricted activity. We CMV infection utero, fetal expand become differentiated. expansion was restricted Vgamma9-negative...