A5052129033- Forensic and Genetic Research
- Genetic diversity and population structure
- Race, Genetics, and Society
- Identification and Quantification in Food
- Archaeology and ancient environmental studies
- Forensic Anthropology and Bioarchaeology Studies
- Genetic Associations and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Genetic and phenotypic traits in livestock
- Parasite Biology and Host Interactions
- Genetics and Physical Performance
- Genetic Mapping and Diversity in Plants and Animals
- Marine Ecology and Invasive Species
- Marine Biology and Ecology Research
- Molecular Biology Techniques and Applications
- Fish Biology and Ecology Studies
- Isotope Analysis in Ecology
- Ichthyology and Marine Biology
- Genomics and Phylogenetic Studies
- Aquatic life and conservation
- Historical and Archaeological Studies
- Muscle Physiology and Disorders
- Paleopathology and ancient diseases
- Sports Performance and Training
- Linguistics and language evolution
University of Cagliari
2018-2024
University of Sassari
2009-2018
Natura (Brazil)
2014
Istituto di Genetica Molecolare
1996
University of Pisa
1988-1989
Mitochondrial DNA (mtDNA) sequence variation was examined in Finns, Swedes and Tuscans by PCR amplification restriction analysis. About 99% of the mtDNAs were subsumed within 10 mtDNA haplogroups (H, I, J, K, M, T, U, V, W, X) suggesting that identified could encompass virtually all European mtDNAs. Because both hypervariable segments control region previously sequenced Tuscan samples, sequences be compared. Using a combination haplogroup-specific site changes nucleotide substitutions,...
A genetic perspective of human history in Europe was derived from 22 binary markers the nonrecombining Y chromosome (NRY). Ten lineages account for >95% 1007 European chromosomes studied. Geographic distribution and age estimates alleles are compatible with two Paleolithic one Neolithic migratory episode that have contributed to modern gene pool. significant correlation between NRY haplotype data principal components based on 95 protein observed, indicating effectiveness polymorphisms...
Genetic variation within the male-specific portion of Y chromosome (MSY) can clarify origins contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 which have not previously been observed. We constructed a phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters each haplogroup. The was...
Abstract Despite centuries of research, much about the barbarian migrations that took place between fourth and sixth in Europe remains hotly debated. To better understand this key era marks dawn modern European societies, we obtained ancient genomic DNA from 63 samples two cemeteries (from Hungary Northern Italy) have been previously associated with Longobards, a people ruled large parts Italy for over 200 years after invading Pannonia 568 CE. Our dense cemetery-based sampling revealed each...
The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists millennia. Over the past four decades, have employed genetic data in an effort achieve this goal but with limited success. While biogeographical algorithms using next-generation sequencing achieved accuracy 700 km Europe, they were inaccurate elsewhere. Here we describe Geographic Population Structure (GPS) algorithm and demonstrate its three sets 40,000-130,000 SNPs. GPS...
The control region of mitochondrial DNA has been widely studied in various human populations. This paper reports sequence data for hypervariable segments 1 and 2 the from a population southern Tuscany (Italy). results confirm high variability region, with 43 different haplotypes 49 individuals sampled. comparison this set other European populations allows reconstruction history Tuscany. Independent approaches, such as estimation haplotype diversity, mean pairwise differences, genetic...
Abstract Background The human gastric pathogen Helicobacter pylori is co-evolved with its host and therefore, origins expansion of multiple populations sub H. mirror ancient migrations. Ancestral in the vast Indian subcontinent are debatable. It not clear how different waves migrations South Asia shaped population structure . We tried to address these issues through mapping genetic present day India their genomic comparison hundreds isolates from geographic regions. Results attempted dissect...
The Genographic Project is an international effort aimed at charting human migratory history. project nonprofit and nonmedical, and, through its Legacy Fund, supports locally led efforts to preserve indigenous traditional cultures. Although the first phase of was focused on uniparentally inherited markers Y-chromosome mitochondrial DNA (mtDNA), current focuses from across entire genome obtain a more complete understanding genetic variation. many commercial arrays exist for genome-wide...
The animal and plant biodiversity of the Italian territory is known to be one richest in Mediterranean basin Europe as a whole, but does genetic diversity extant human populations show comparable pattern? According number studies, structure retains signatures complex peopling processes which took place from Paleolithic modern era. Although observed patterns highlight remarkable degree heterogeneity, they do not, however, take into account an important source variation. In fact, Italy home...
As the collapse of Western Roman Empire accelerated during 4th and 5th centuries, arriving "barbarian" groups began to establish new communities in border provinces declining (and eventually former) empire. This was a time significant cultural political change throughout not only these regions but Europe as whole.1,2 To better understand post-Roman community formation one key frontier zones after Hunnic movement, we generated paleogenomic data for set 38 burials from series three century...
Abstract An informative set of biallelic polymorphisms was used to study the structure Y‐chromosome variability in a sample from Mediterranean islands Corsica and Sicily, compared with data on Sardinia gain insights into ethnogenesis these island populations. The results were interpreted broader context by including analysis neighboring populations previously studied same methodology. All samples enclosed comparable spectrum European variability. Pronounced differences observed between as...
The island of Sardinia shows a unique high incidence several autoimmune diseases with multifactorial inheritance, particularly type 1 diabetes and multiple sclerosis. prior knowledge the genetic structure this population is fundamental to establish optimal design for association studies in these diseases. Previous work suggested that Sardinians are relatively homogenous population, but some reports were contradictory data largely based on variants subject selection. For an unbiased...
Leptospirosis is an important zoonosis with widespread human health implications. The non-availability of accurate identification methods for the individualization different Leptospira outbreak investigations poses bountiful problems in disease control arena. We harnessed fluorescent amplified fragment length polymorphism analysis (FAFLP) and investigated its utility establishing genetic relationships among 271 isolates context species level assignments our global collection strains obtained...
Pinna nobilis is the largest endemic Mediterranean marine bivalve. During past centuries, various human activities have promoted regression of its populations. As a consequence stringent standards protection, demographic expansions are currently reported in many sites. The aim this study was to provide first large broad-scale insight into genetic variability P. area that encompasses western Mediterranean, Ionian Sea, and Adriatic Sea ecoregions. To accomplish objective twenty-five...
Sheep are thought to have been one of the first livestock be domesticated in Near East, thus playing an important role human history. The current whole mitochondrial genome phylogeny for genus Ovis is based on: five main domestic haplogroups occurring among sheep (O. aries), along with molecular data from two wild European mouflons, three urials, and argali. With aim shed some further light on phylogenetic relationship within this genus, complete sequence a Cypriot mouflon gmelini ophion)...
The use of ancient DNA techniques in human studies has been hampered by problems contamination with modern DNA. main problem that the object study belongs to same species as observer, and complete elimination risk is seemingly unlikely. Contamination even detected most specialized laboratories this field. In these kinds it therefore very important detect distinguish contaminants from authentic results. Here, we report a strategy authenticate identity mitochondrial (mtDNA), based on...
Two alternative models have been proposed to explain the spread of agriculture in Europe during Neolithic period. The demic diffusion model postulates spreading farmers from Middle East along a Southeast Northeast axis. Conversely, cultural assumes transmission agricultural techniques without substantial movements people. Support for derives largely observation frequency gradients among some genetic variants, particular haplogroups defined by single nucleotide polymorphisms (SNPs)...
Pinna nobilis is the largest endemic Mediterranean marine bivalve. During past centuries, various human activities led to regression of its populations. As a consequence stringent standards protection, demographic expansions are currently reported in many sites. We designed set four mitochondrial- and two nuclear- specific PCR-primers with aim provide molecular tools gather new insights into genetic variability this species. A total 54 specimens were sampled from 25 localities order evaluate...
Vitamin D receptor (VDR) is an important candidate gene in musculoskeletal phenotypes. Polymorphisms VDR have been previously associated with several pathologies and muscular strength athletes elderly people, however literature reported contradictory results. The object of this research to verify the association between most studied variants (rs2228570, rs7975232, rs1544410) increase muscle mass elite young soccer players. A sample 55 players (15-18 years old) form a professional team was...