Eran Elhaik
A5060706701- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- RNA and protein synthesis mechanisms
- Race, Genetics, and Society
- Multiple Myeloma Research and Treatments
- Gut microbiota and health
- Genomic variations and chromosomal abnormalities
- Genetic and phenotypic traits in livestock
- Morphological variations and asymmetry
- Epigenetics and DNA Methylation
- Evolution and Genetic Dynamics
- Fractal and DNA sequence analysis
- Chromosomal and Genetic Variations
- Amyotrophic Lateral Sclerosis Research
- Chronic Lymphocytic Leukemia Research
- Genetic Mapping and Diversity in Plants and Animals
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Archaeology and ancient environmental studies
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Infant Health and Development
- RNA Research and Splicing
Lund University
2019-2025
University of Sheffield
2014-2023
Mayo Clinic
2023
Insigneo
2015-2018
University of Houston
2005-2015
Johns Hopkins University
2010-2014
High Throughput Biology (United States)
2012
Johns Hopkins Medicine
2010-2012
Tribolium castaneum is a member of the most species-rich eukaryotic order, powerful model organism for study generalized insect development, and an important pest stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved ability to interact with diverse chemical environment, as shown by large expansions in odorant gustatory receptors, well P450 other detoxification enzymes. Development more representative insects than Drosophila, fact reflected...
To understand the biology and evolution of ruminants, cattle genome was sequenced to about sevenfold coverage. The contains a minimum 22,000 genes, with core set 14,345 orthologs shared among seven mammalian species which 1217 are absent or undetected in noneutherian (marsupial monotreme) genomes. Cattle-specific evolutionary breakpoint regions chromosomes have higher density segmental duplications, enrichment repetitive elements, species-specific variations genes associated lactation immune...
A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications, specifically the article signed by all members, put forward idea that more than 80% human genome is functional. This claim flies in face current estimates according to which fraction evolutionarily conserved through purifying selection less 10%. Thus, ENCODE Consortium, a biological function can be maintained indefinitely without selection, implies at least 80 − 10 = 70% perfectly invulnerable deleterious...
We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog urban microbial ecosystem. This provides an annotated, geospatial profile strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, 838,532 CRISPR arrays not found reference databases. identified 4,246 known species microorganisms consistent...
Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report first extensive genomic characterization microbiomes, pathogens antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up 1.5 years apart) 179 sites associated with 45 beds. Deep shotgun metagenomics unveiled distinct ecological niches genes characterized by biofilm-forming human-microbiome-influenced...
Principal Component Analysis (PCA) is a multivariate analysis that reduces the complexity of datasets while preserving data covariance. The outcome can be visualized on colorful scatterplots, ideally with only minimal loss information. PCA applications, implemented in well-cited packages like EIGENSOFT and PLINK, are extensively used as foremost analyses population genetics related fields (e.g., animal plant or medical genetics). outcomes to shape study design, identify, characterize...
Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death. Despite heritability estimates of 52%, genome-wide association studies (GWASs) have discovered relatively few loci. We developed machine learning approach called RefMap, which integrates functional genomics with GWAS summary statistics for gene discovery. With transcriptomic and epigenetic profiling neurons derived from induced pluripotent stem cells (iPSCs), RefMap identified 690 ALS-associated genes...
The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists millennia. Over the past four decades, have employed genetic data in an effort achieve this goal but with limited success. While biogeographical algorithms using next-generation sequencing achieved accuracy 700 km Europe, they were inaccurate elsewhere. Here we describe Geographic Population Structure (GPS) algorithm and demonstrate its three sets 40,000-130,000 SNPs. GPS...
The Metagenomics and Metadesign of the Subways Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised experts across many fields, including genomics, data analysis, engineering, public health, architecture. ultimate goal MetaSUB to improve city utilization planning through detection, measurement, design metagenomics within urban environments. Although continual measures occur for temperature, air pressure, weather, human activity, longitudinal,...
Antimicrobial resistance is one of the biggest challenges facing modern medicine. Because management COVID-19 increasingly becoming dependent on pharmacological interventions, there greater risk for accelerating evolution and spread antimicrobial resistance. A study in a tertiary hospital environment revealed concerning colonisation patterns microbes during extended periods.1 It also highlighted diversity gene reservoirs hospitals that could facilitate emergence transmission new modes antibiotic
Variability in disease severity caused by a microbial pathogen is impacted each infection representing unique combination of host and genomes. Here, we show that the outcome invasive Streptococcus pyogenes regulated an interplay between human STING genotype bacterial NADase activity. S. pyogenes-derived c-di-AMP diffuses via streptolysin O pores into macrophages where it activates ensuing type I IFN response. However, enzymatic activity variants expressed strains suppresses STING-mediated...
The Genographic Project is an international effort aimed at charting human migratory history. project nonprofit and nonmedical, and, through its Legacy Fund, supports locally led efforts to preserve indigenous traditional cultures. Although the first phase of was focused on uniparentally inherited markers Y-chromosome mitochondrial DNA (mtDNA), current focuses from across entire genome obtain a more complete understanding genetic variation. many commercial arrays exist for genome-wide...
The GC content in the third codon position (GC(3)) exhibits a unimodal distribution many plant and animal genomes. Interestingly, grasses homeotherm vertebrates exhibit unique bimodal distribution. High GC(3) was previously found to be associated with variable expression, higher frequency of upstream TATA boxes, an increase from 5' 3'. Moreover, GC(3)-rich genes are predominant certain gene classes enriched CpG dinucleotides that potential targets for methylation. Based on we hypothesize has...
Abstract Multiple myeloma (MM) is two- to three-fold more common in African Americans (AAs) compared European (EAs). This striking disparity, one of the highest any cancer, may be due underlying genetic predisposition between these groups. There are multiple unique cytogenetic subtypes MM, and it likely that disparity associated with only certain subtypes. Previous efforts understand this have relied on self-reported race rather than ancestry, which result bias. To mitigate difficulties, we...
Abstract It is widely accepted that humans interbred with Neanderthals and other extinct hominins, leaving a lasting genetic legacy. However, much of the supporting evidence was developed using statistic D, which assumes, without testing, both mutation rate constant recurrent mutations are vanishingly rare. These assumptions together preclude an alternative explanation based on variation in rates across human populations. Here we critically evaluate underlying D confirm neither valid. Over...
Studies of the apportionment human genetic variation have long established that most is within population groups and additional between small but greatest when comparing different continental populations. These studies often used Wright's FST apportions standardized variance in allele frequencies groups. Because local adaptations increase differentiation, high-FST may be found at closely linked loci under selection to identify genes undergoing directional or heterotic selection. We...
The question of Jewish ancestry has been the subject controversy for over two centuries and yet to be resolved. "Rhineland hypothesis" depicts Eastern European Jews as a "population isolate" that emerged from small group German who migrated eastward expanded rapidly. Alternatively, "Khazarian suggests descended Khazars, an amalgam Turkic clans settled Caucasus in early CE converted Judaism 8th century. Mesopotamian Greco-Roman continuously reinforced Judaized empire until 13th Following...
The Yiddish language is over 1,000 years old and incorporates German, Slavic, Hebrew elements. prevalent view claims has a German origin, whereas the opposing posits Slavic origin with strong Iranian weak Turkic substrata. One of major difficulties in deciding between these hypotheses unknown geographical speaking Ashkenazic Jews (AJs). An analysis 393 Ashkenazic, Iranian, mountain 600 non-Jewish genomes demonstrated that Greeks, Romans, Iranians, Turks exhibit highest genetic similarity...
Abstract We have created a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities across 3 years. This is the first systematic, worldwide study cataloging urban microbial ecosystem. identify taxonomically-defined microorganisms collected three provides an annotated, geospatial profile strains, functional characteristics AMR markers, and novel genetic elements, including 10,928 viral, 1302 bacteria, 2 archaea species. 4,424 species consistent “core” 31 found nearly...